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Page 1
Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
Jansen WJ, Janssen O, Tijms BM, Vos SJB, Ossenkoppele R, Visser PJ; Amyloid Biomarker Study Group; Aarsland D, Alcolea D, Altomare D, von Arnim C, Baiardi S, Baldeiras I, Barthel H, Bateman RJ, Van Berckel B, Binette AP, Blennow K, Boada M, Boecker H, Bottlaender M, den Braber A, Brooks DJ, Van Buchem MA, Camus V, Carill JM, Cerman J, Chen K, Chételat G, Chipi E, Cohen AD, Daniels A, Delarue M, Didic M, Drzezga A, Dubois B, Eckerström M, Ekblad LL, Engelborghs S, Epelbaum S, Fagan AM, Fan Y, Fladby T, Fleisher AS, Van der Flier WM, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Frings L, Frisoni GB, Fröhlich L, Gabryelewicz T, Gertz HJ, Gill KD, Gkatzima O, Gómez-Tortosa E, Grimmer T, Guedj E, Habeck CG, Hampel H, Handels R, Hansson O, Hausner L, Hellwig S, Heneka MT, Herukka SK, Hildebrandt H, Hodges J, Hort J, Huang CC, Iriondo AJ, Itoh Y, Ivanoiu A, Jagust WJ, Jessen F, Johannsen P, Johnson KA, Kandimalla R, Kapaki EN, Kern S, Kilander L, Klimkowicz-Mrowiec A, Klunk WE, Koglin N, Kornhuber J, Kramberger MG, Kuo HC, Van Laere K, Landau SM, Landeau B, Lee DY, de Leon M, Leyton CE, Lin KJ, Lleó A, Löwenmark M, Madsen K, Maier W, Marcusson J, Marquié M, Martinez-Lage P,… See abstract for full author list ➔ Jansen WJ, et al. Among authors: ekblad ll. JAMA Neurol. 2022 Mar 1;79(3):228-243. doi: 10.1001/jamaneurol.2021.5216. JAMA Neurol. 2022. PMID: 35099509
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly.
Koivumäki M, Ekblad L, Lantero-Rodriguez J, Ashton NJ, Karikari TK, Helin S, Parkkola R, Lötjönen J, Zetterberg H, Blennow K, Rinne JO, Snellman A. Koivumäki M, et al. Among authors: ekblad l. Alzheimers Res Ther. 2024 May 18;16(1):112. doi: 10.1186/s13195-024-01477-w. Alzheimers Res Ther. 2024. PMID: 38762725 Free PMC article.
Here, we aimed to (i) assess differences in blood and imaging biomarkers used to evaluate neurodegeneration among cognitively unimpaired APOE epsilon4 homozygotes, heterozygotes, and non-carriers with varying risk for sporadic AD, and (ii) to determine how different cerebral path …
Here, we aimed to (i) assess differences in blood and imaging biomarkers used to evaluate neurodegeneration among cognitively unimpaired APO …
Innervation of the gastric mucosa.
Ekblad E, Mei Q, Sundler F. Ekblad E, et al. Microsc Res Tech. 2000 Mar 1;48(5):241-57. doi: 10.1002/(SICI)1097-0029(20000301)48:5<241::AID-JEMT2>3.0.CO;2-2. Microsc Res Tech. 2000. PMID: 10700042 Review.
Gastric nerves are either intrinsic to the gastric wall, i.e., they have their cell bodies in the intramural ganglia and thus belong to the enteric nervous system, or they reach the stomach from outside, originating in the brainstem, in sympathetic ganglia, or in sensory g …
Gastric nerves are either intrinsic to the gastric wall, i.e., they have their cell bodies in the intramural ganglia and thus belong …
Early implementation of QbD in biopharmaceutical development: a practical example.
Zurdo J, Arnell A, Obrezanova O, Smith N, Gómez de la Cuesta R, Gallagher TR, Michael R, Stallwood Y, Ekblad C, Abrahmsén L, Höidén-Guthenberg I. Zurdo J, et al. Among authors: ekblad c. Biomed Res Int. 2015;2015:605427. doi: 10.1155/2015/605427. Epub 2015 May 17. Biomed Res Int. 2015. PMID: 26075248 Free PMC article. Review.
In drug development, the "onus" of the low R&D efficiency has been put traditionally onto the drug discovery process (i.e., finding the right target or "binding" functionality). Here, we show that manufacturing is not only a central component of product success, but al …
In drug development, the "onus" of the low R&D efficiency has been put traditionally onto the drug discovery process (i.e., findi …
Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer's disease.
Snellman A, Ekblad LL, Ashton NJ, Karikari TK, Lantero-Rodriguez J, Pietilä E, Koivumäki M, Helin S, Karrasch M, Zetterberg H, Blennow K, Rinne JO. Snellman A, et al. Among authors: ekblad ll. Neurobiol Dis. 2023 Jul;183:106175. doi: 10.1016/j.nbd.2023.106175. Epub 2023 Jun 1. Neurobiol Dis. 2023. PMID: 37268240 Free article.
The neuroendocrine system of the gut--an update.
Sundler F, Ekblad E, Håkanson R. Sundler F, et al. Among authors: ekblad e. Acta Oncol. 1991;30(4):419-27. doi: 10.3109/02841869109092396. Acta Oncol. 1991. PMID: 1854499 Review.
Thus, gastrin cells in many species store GABA and peptide YY; in e.g. cat and man they store in addition a xenopsin-like peptide. Neuromedin U and pituitary adenylate cyclase activating peptide (PACAP) have recently been demonstrated in gut nerves. ...
Thus, gastrin cells in many species store GABA and peptide YY; in e.g. cat and man they store in addition a xenopsin-like peptide. Ne …
APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly.
Snellman A, Ekblad LL, Tuisku J, Koivumäki M, Ashton NJ, Lantero-Rodriguez J, Karikari TK, Helin S, Bucci M, Löyttyniemi E, Parkkola R, Karrasch M, Schöll M, Zetterberg H, Blennow K, Rinne JO. Snellman A, et al. Among authors: ekblad ll. Alzheimers Res Ther. 2023 Apr 4;15(1):71. doi: 10.1186/s13195-023-01209-6. Alzheimers Res Ther. 2023. PMID: 37016464 Free PMC article.
Role of vasoactive intestinal peptide and inflammatory mediators in enteric neuronal plasticity.
Ekblad E, Bauer AJ. Ekblad E, et al. Neurogastroenterol Motil. 2004 Apr;16 Suppl 1:123-8. doi: 10.1111/j.1743-3150.2004.00487.x. Neurogastroenterol Motil. 2004. PMID: 15066017 Review.
Complex circuits involving both local intrinsic neurones (i.e. enteric nervous system; ENS) and extrinsic neurones achieve nervous control of digestive functions. ...It must be emphasized, however, that not only muscle and secretory cells but also other intestinal cells ar …
Complex circuits involving both local intrinsic neurones (i.e. enteric nervous system; ENS) and extrinsic neurones achieve nervous co …
Renal hyperfiltration revisited-Role of the individual body surface area on mortality.
Korhonen PE, Ekblad MO, Kautiainen H, Mäkelä S. Korhonen PE, et al. Among authors: ekblad mo. Eur J Intern Med. 2023 Aug;114:101-107. doi: 10.1016/j.ejim.2023.04.032. Epub 2023 May 6. Eur J Intern Med. 2023. PMID: 37156713 Free article.
BACKGROUND: Higher than normal estimated glomerular filtration rate (eGFR), i.e. renal hyperfiltration (RHF), has been associated with mortality. METHODS: A population-based screening program in Finland identified 1747 apparently healthy middle-aged cardiovascular risk sub …
BACKGROUND: Higher than normal estimated glomerular filtration rate (eGFR), i.e. renal hyperfiltration (RHF), has been associated wit …
70 results