Targeting the DNA damage response in hematological malignancies.
De Mel S, Lee AR, Tan JHI, Tan RZY, Poon LM, Chan E, Lee J, Chee YL, Lakshminarasappa SR, Jaynes PW, Jeyasekharan AD.
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Front Oncol. 2024 Jan 29;14:1307839. doi: 10.3389/fonc.2024.1307839. eCollection 2024.
Front Oncol. 2024.
PMID: 38347838
Free PMC article.
Review.
The dependency of certain cancers on DDR pathways has enabled exploitation of such through synthetically lethal relationships e.g., Poly ADP-Ribose Polymerase (PARP) inhibitors for BRCA deficient ovarian cancers. ...
The dependency of certain cancers on DDR pathways has enabled exploitation of such through synthetically lethal relationships e.g., P …