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1989 1
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Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly: the Japan Public Health Center-based Prospective Study.
Hamazaki K, Matsuoka YJ, Yamaji T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S. Hamazaki K, et al. Sci Rep. 2021 Feb 17;11(1):4003. doi: 10.1038/s41598-021-83478-5. Sci Rep. 2021. PMID: 33597590 Free PMC article.
The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on depression are not definitively known. In a previous population-based prospective cohort study, we found a reverse J-shaped association o …
The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on d …
Low unesterified:esterified eicosapentaenoic acid (EPA) plasma concentration ratio is associated with bipolar disorder episodes, and omega-3 plasma concentrations are altered by treatment.
Saunders EF, Reider A, Singh G, Gelenberg AJ, Rapoport SI. Saunders EF, et al. Bipolar Disord. 2015 Nov;17(7):729-42. doi: 10.1111/bdi.12337. Epub 2015 Oct 1. Bipolar Disord. 2015. PMID: 26424416 Free PMC article.

Exploratory comparison showed lower UE:E EPA in the BD than the HC group (p < 0.0001). At follow-up in the BD group, UE, E DHA:ALA, and UE EPA:ALA were decreased (p < 0.002). Exploratory correlations of clinical variables revealed that mania severity and suici

…

Exploratory comparison showed lower UE:E EPA in the BD than the HC group (p < 0.0001). At follow-up in the BD group, UE, E

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Supplementation with eicosapentaenoic omega-3 fatty acid does not influence serum brain-derived neurotrophic factor in diabetes mellitus patients with major depression: a randomized controlled pilot study.
Bot M, Pouwer F, Assies J, Jansen EH, Beekman AT, de Jonge P. Bot M, et al. Neuropsychobiology. 2011;63(4):219-23. doi: 10.1159/000321804. Epub 2011 Mar 22. Neuropsychobiology. 2011. PMID: 21422768 Clinical Trial.
RESULTS: We found no effect of E-EPA on BDNF levels (t = -0.144, p = 0.887), and changes in BDNF levels and depression severity were not significantly associated (Spearman's rho = -0.115, p = 0.593). CONCLUSION: Our study does not provide evidence that supple …
RESULTS: We found no effect of E-EPA on BDNF levels (t = -0.144, p = 0.887), and changes in BDNF levels and depression …
Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: a randomized, double-blind placebo-controlled study.
Bot M, Pouwer F, Assies J, Jansen EH, Diamant M, Snoek FJ, Beekman AT, de Jonge P. Bot M, et al. J Affect Disord. 2010 Oct;126(1-2):282-6. doi: 10.1016/j.jad.2010.04.008. Epub 2010 May 14. J Affect Disord. 2010. PMID: 20466431 Free article. Clinical Trial.
METHODS: In the VU University Medical Center, we conducted a 12-week, placebo-controlled, double-blind, parallel-group intervention study of E-EPA (1g/day) versus placebo in 25 diabetes patients meeting DSM-IV criteria for major depressive disorder, wh …
METHODS: In the VU University Medical Center, we conducted a 12-week, placebo-controlled, double-blind, parallel-group intervention study of …
Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial.
Lucas M, Asselin G, Mérette C, Poulin MJ, Dodin S. Lucas M, et al. Am J Clin Nutr. 2009 Feb;89(2):641-51. doi: 10.3945/ajcn.2008.26749. Epub 2008 Dec 30. Am J Clin Nutr. 2009. PMID: 19116322 Free article. Clinical Trial.
Studies suggest that omega-3 (n-3) fatty acids may help alleviate depression. OBJECTIVE: The objective was to compare enriched ethyl-eicosapentaenoic acid (E-EPA) supplementation with placebo for the treatment of PD and depressive symptoms in middle-ag …
Studies suggest that omega-3 (n-3) fatty acids may help alleviate depression. OBJECTIVE: The objective was to compare enriched ethyl- …
Ethyl-eicosapentaenoate and dexamethasone resistance in therapy-refractory depression.
Murck H, Song C, Horrobin DF, Uhr M. Murck H, et al. Int J Neuropsychopharmacol. 2004 Sep;7(3):341-9. doi: 10.1017/S1461145704004249. Epub 2004 Mar 5. Int J Neuropsychopharmacol. 2004. PMID: 15003146 Free article. Review.
Preliminary evidence shows that ethyl-eicosapentaenoate (E-EPA) has a marked clinical effect when used as an adjunct in therapy-refractory depression. EPA belongs to the class of polyunsaturated omega-3 fatty acids. The mechanism of its action in depressio …
Preliminary evidence shows that ethyl-eicosapentaenoate (E-EPA) has a marked clinical effect when used as an adjunct in therap …
omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study.
Zanarini MC, Frankenburg FR. Zanarini MC, et al. Am J Psychiatry. 2003 Jan;160(1):167-9. doi: 10.1176/appi.ajp.160.1.167. Am J Psychiatry. 2003. PMID: 12505817 Clinical Trial.
OBJECTIVE: The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder. ...CONCLUSIONS: The results of this study suggest that E-EP …
OBJECTIVE: The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the tre …
Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder.
Nemets B, Stahl Z, Belmaker RH. Nemets B, et al. Am J Psychiatry. 2002 Mar;159(3):477-9. doi: 10.1176/appi.ajp.159.3.477. Am J Psychiatry. 2002. PMID: 11870016 Clinical Trial.
OBJECTIVE: Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. The authors studied a specific omega-3 fatty acid, the ethyl ester of eicosapentaenoic acid (E-EPA), as an adjunct to treatme …
OBJECTIVE: Studies have reported that countries with high rates of fish oil consumption have low rates of depressive disorder. …
Fish oil diet affects on oxidative senescence of red blood cells linked to degeneration of spleen cells in mice.
Oarada M, Furukawa H, Majima T, Miyazawa T. Oarada M, et al. Biochim Biophys Acta. 2000 Aug 24;1487(1):1-14. doi: 10.1016/s1388-1981(00)00076-7. Biochim Biophys Acta. 2000. PMID: 11004607
A 43% increase in spleen weight, about twice as many spleen cells and no change in the subpopulations of spleen cells, as well as a significant depression of mitogen-induced blastogenesis of both T and B cells in the spleen were observed in mice fed fish oil for 30 days in …
A 43% increase in spleen weight, about twice as many spleen cells and no change in the subpopulations of spleen cells, as well as a signific …
Effect of oral ingestion of eicosapentaenoic acid-ethyl ester on natural killer cell activity in rat spleen cells.
Chang KJ, Saito H, Tamura Y, Watanabe K, Yoshida S. Chang KJ, et al. Prostaglandins Leukot Essent Fatty Acids. 1989 Jul;37(1):31-5. doi: 10.1016/0952-3278(89)90183-x. Prostaglandins Leukot Essent Fatty Acids. 1989. PMID: 2548219
EPA-E ingestion during four weeks (100 mg/kg/day) significantly depressed NK cell activity. After EPA-E ingestion, EPA content in the spleen cell lipids was significantly increased, compared to that in control rat spleen cells, and AA content was not changed. Production of …
EPA-E ingestion during four weeks (100 mg/kg/day) significantly depressed NK cell activity. After EPA-E ingestion, EPA content in the …