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Did you mean ed local anesthetic resistance (88 results)?
Resistance to local anesthesia in people with the Ehlers-Danlos Syndromes presenting for dental surgery.
Schubart JR, Schaefer E, Janicki P, Adhikary SD, Schilling A, Hakim AJ, Bascom R, Francomano CA, Raj SR. Schubart JR, et al. J Dent Anesth Pain Med. 2019 Oct;19(5):261-270. doi: 10.17245/jdapm.2019.19.5.261. Epub 2019 Oct 30. J Dent Anesth Pain Med. 2019. PMID: 31723666 Free PMC article.
BACKGROUND: People with the Ehlers-Danlos Syndromes (EDS), a group of heritable disorders of connective tissue, often report experiencing dental procedure pain despite local anesthetic (LA) use. Clinicians have been uncertain how to interpret this apparent LA …
BACKGROUND: People with the Ehlers-Danlos Syndromes (EDS), a group of heritable disorders of connective tissue, often report experien …
Genome-wide gene by sleepiness interaction analysis for sleep apnea.
Nagarajan P, Kurniansyah N, Lee J, Gharib SA, Xu Y, Zhang Y, Spitzer B, Faquih T, Zhou H, Boerwinkle E, Chen H, Gottlieb DJ, Guo X, Heard-Costa NL, Hidalgo BA, Levy D, Liu PY, Mei H, Montalvan R, Mukherjee S, North KE, O'Connor GT, Palmer LJ, Patel SR, Psaty BM, Purcell SM, Raffield LM, Rich SS, Rotter JI, Saxena R, Smith AV, Stone KL, Zhu X; TOPMed Sleep Trait Working Group; Cade BE, Sofer T, Redline S, Wang H. Nagarajan P, et al. Sleep. 2026 Jan 13;49(1):zsaf212. doi: 10.1093/sleep/zsaf212. Sleep. 2026. PMID: 40736211 Free PMC article.
However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-by-EDS interaction analyses for apnea hypopnea index, a diagnostic marker of sleep apnea severity, to understand EDS's influenc …
However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-b …
Patients with Ehlers-Danlos syndrome experience reduced effectiveness of lidocaine local anesthetic: a randomized cross-over clinical trial.
Bourne KM, Thai S, Lei LY, Siddiqui T, Black B, Peltier A, Paranjape S, Shibao CA, Biaggioni I, Diedrich A, Gamboa A, Okamoto L, Sheldon RS, Raj SR. Bourne KM, et al. Reg Anesth Pain Med. 2026 Mar 3:rapm-2025-107416. doi: 10.1136/rapm-2025-107416. Online ahead of print. Reg Anesth Pain Med. 2026. PMID: 41775498 Free PMC article.
BACKGROUND: The Ehlers-Danlos syndromes (EDS) are a collection of heritable connective tissue disorders. Local anesthetic resistance is commonly reported by patients with EDS, but there is little clinical evidence to support this finding. ...CON …
BACKGROUND: The Ehlers-Danlos syndromes (EDS) are a collection of heritable connective tissue disorders. Local anesthetic …
Management of chronic pain in Ehlers-Danlos syndrome: Two case reports and a review of literature.
Zhou Z, Rewari A, Shanthanna H. Zhou Z, et al. Medicine (Baltimore). 2018 Nov;97(45):e13115. doi: 10.1097/MD.0000000000013115. Medicine (Baltimore). 2018. PMID: 30407326 Free PMC article. Review.
Overall, approximately 90% or more EDS patients suffer from chronic pain. There are no existing guidelines to manage chronic pain in EDS patients. ...The caution that they are resistant to local anesthetics is unwarranted. Appropriate pain inter …
Overall, approximately 90% or more EDS patients suffer from chronic pain. There are no existing guidelines to manage chronic pain in …
Treatment of the wide open wound in the Ehlers-Danlos syndrome.
Baik BS, Lee WS, Park KS, Yang WS, Ji SY. Baik BS, et al. Arch Craniofac Surg. 2019 Apr;20(2):130-133. doi: 10.7181/acfs.2018.02334. Epub 2019 Apr 20. Arch Craniofac Surg. 2019. PMID: 31048651 Free PMC article.
Surgery patients with an EDS require an experienced surgeon in treating EDS patients; the treatment process requires careful tissue handling and a long postoperative care. A surgeon should also recognize whether the patient shows a resistance to local …
Surgery patients with an EDS require an experienced surgeon in treating EDS patients; the treatment process requires careful t …
Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype.
Nagarajan P, Kurniansyah N, Lee J, Gharib SA, Xu Y, Zhang Y, Spitzer B, Faquih T, Zhou H, Boerwinkle E, Chen H, Gottlieb DJ, Guo X, Heard-Costa NL, Hidalgo BA, Levy D, Liu PY, Mei H, Montalvan R, Mukherjee S, North KE, O'Conner GT, Palmer LJ, Patel SR, Psaty BM, Purcell SM, Raffield LM, Rich SS, Rotter JI, Saxena R, Smith AV, Stone KL, Zhu X; TOPMed Sleep Trait WG; Cade BE, Sofer T, Redline S, Wang H. Nagarajan P, et al. medRxiv [Preprint]. 2024 Oct 28:2024.10.25.24316158. doi: 10.1101/2024.10.25.24316158. medRxiv. 2024. PMID: 39574859 Free PMC article. Preprint.
It is recognized as a clinical subtype underlying OSA carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS as an exposure variable, we sought to investigate EDS's influence on genetic variation linked to apnea-hypopnea index (AHI), a diagnosti …
It is recognized as a clinical subtype underlying OSA carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS as …
A rational approach to the outpatient management of lacerations in pediatric patients.
Kanegaye JT. Kanegaye JT. Curr Probl Pediatr. 1998 Aug;28(7):205-34. doi: 10.1016/s0045-9380(98)80048-0. Curr Probl Pediatr. 1998. PMID: 9740986 Review.
Although skin closure is often viewed as the primary event in wound care, local anesthesia and wound toilet are equally important aspects in which expertise is often undervalued. On occasion, patient anxiety and resistance complicates wound care, and a variet …
Although skin closure is often viewed as the primary event in wound care, local anesthesia and wound toilet are equally import …
Dispersal of radioisotope labelled solution following deep dermal injection in Ehlers-Danlos syndrome.
Oliver DW, Balan KK, Burrows NP, Hall PN. Oliver DW, et al. Br J Plast Surg. 2000 Jun;53(4):308-12. doi: 10.1054/bjps.2000.3338. Br J Plast Surg. 2000. PMID: 10876255
Patients with EDS have reported that local anaesthetic is often ineffective. Patients with less severe skin laxity often have the most problems. ...The diagnosis of EDS should be considered in any patient who complains unexpectedly of pain during their …
Patients with EDS have reported that local anaesthetic is often ineffective. Patients with less severe skin laxity ofte …
Oro-dental characteristics in patients with hypermobile Ehlers-Danlos Syndrome compared to a healthy control group.
Honoré MB, Lauridsen EF, Sonnesen L. Honoré MB, et al. J Oral Rehabil. 2019 Nov;46(11):1055-1064. doi: 10.1111/joor.12838. Epub 2019 Jun 27. J Oral Rehabil. 2019. PMID: 31206735

RESULTS: The experience of xerostomia (P = 0.039), local anaesthetic insufficiency (P < 0.001) and tooth extraction complications (P < 0.003) were significantly higher in hEDS compared to controls. ...CONCLUSION: The results indicate that xerostomia, resist

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RESULTS: The experience of xerostomia (P = 0.039), local anaesthetic insufficiency (P < 0.001) and tooth extraction complic

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The treatment of cutaneous abscesses: comparison of emergency medicine providers' practice patterns.
Schmitz G, Goodwin T, Singer A, Kessler CS, Bruner D, Larrabee H, May L, Luber SD, Williams J, Bhat R. Schmitz G, et al. West J Emerg Med. 2013 Feb;14(1):23-8. doi: 10.5811/westjem.2011.9.6856. West J Emerg Med. 2013. PMID: 23447753 Free PMC article.
Most providers (76%) used narcotics for pain management, 71% used local anesthetic over the roof of the abscess, and 60% used local anesthetic in a field block for pain control. ...Most providers used narcotic analgesics in addition to local …
Most providers (76%) used narcotics for pain management, 71% used local anesthetic over the roof of the abscess, and 60% used …
15 results