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4,456 results

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Page 1
What Is Parvalbumin for?
Permyakov EA, Uversky VN. Permyakov EA, et al. Biomolecules. 2022 Apr 30;12(5):656. doi: 10.3390/biom12050656. Biomolecules. 2022. PMID: 35625584 Free PMC article. Review.
Parvalbumin (PA) is a small, acidic, mostly cytosolic Ca(2+)-binding protein of the EF-hand superfamily. Structural and physical properties of PA are well studied but recently two highly conserved structural motifs consisting of three amino acids each (cluste …
Parvalbumin (PA) is a small, acidic, mostly cytosolic Ca(2+)-binding protein of the EF-hand superfamily. Structural and physic …
An AI-informed NMR structure reveals an extraordinary LETM1 F-EF-hand domain that functions as a two-way regulator of mitochondrial calcium.
Lin QT, Colussi DM, Lake T, Stathopulos PB. Lin QT, et al. Structure. 2024 Nov 7;32(11):2063-2082.e5. doi: 10.1016/j.str.2024.08.020. Epub 2024 Sep 23. Structure. 2024. PMID: 39317198 Free article.
AlphaFold can accurately predict static protein structures but does not account for solvent conditions. Human leucine zipper EF-hand transmembrane protein-1 (LETM1) has one sequence-identifiable EF-hand but how calcium (Ca(2+)) affects structure and fu …
AlphaFold can accurately predict static protein structures but does not account for solvent conditions. Human leucine zipper EF-ha …
The apo LETM1 F-EF-hand adopts a closed conformation that underlies a multi-modal sensory role in mitochondria.
Lin QT, Colussi DM, Stathopulos PB. Lin QT, et al. FEBS Lett. 2025 Apr;599(7):971-988. doi: 10.1002/1873-3468.70006. Epub 2025 Feb 10. FEBS Lett. 2025. PMID: 39927520 Free PMC article.
Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) plays a critical role in mitochondrial function, with haploinsufficiency linked to Wolf-Hirschhorn syndrome. ...Finally, we demonstrate Ca(2+)-dependent transient interactions between the EF- …
Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) plays a critical role in mitochondrial function, with haploi …
Structural and functional diversity of EF-hand proteins: Evolutionary perspectives.
Kawasaki H, Kretsinger RH. Kawasaki H, et al. Protein Sci. 2017 Oct;26(10):1898-1920. doi: 10.1002/pro.3233. Epub 2017 Jul 27. Protein Sci. 2017. PMID: 28707401 Free PMC article. Review.
We have classified 865 sequences of EF-hand proteins from five proteomes into 156 subfamilies. These subfamilies were put into six groups. ...These ancestral sequences reveal that some subfamilies in low similarity and isolated groups did not evolve from the EF …
We have classified 865 sequences of EF-hand proteins from five proteomes into 156 subfamilies. These subfamilies were put into …
EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII.
Zheng C, Liu HH, Zhou J, Zhang B. Zheng C, et al. Blood. 2010 Feb 4;115(5):1081-7. doi: 10.1182/blood-2009-09-241877. Epub 2009 Dec 9. Blood. 2010. PMID: 20007547 Free PMC article.
Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 binding. Circular dichroism spectroscopy studies on missense mutations localized to different structural elements of the EF-hand domains suggest that Ca(2+)-induced folding is i …
Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 binding. Circular dichroism spectroscopy studies on …
EF-Hand Mimicking Calcium Binding Polymer.
Chung HJ, Ko du Y, Moon HJ, Jeong B. Chung HJ, et al. Biomacromolecules. 2016 Mar 14;17(3):1075-82. doi: 10.1021/acs.biomac.5b01694. Epub 2016 Mar 2. Biomacromolecules. 2016. PMID: 26909543
There are four EF-hand polypeptides in calmodulin, a natural ubiquitous calcium binding protein that activates the enzymes involved in Ca(2+)-mediated signal transduction. An EF-hand polypeptide has six carboxylate functional groups in the middle loop …
There are four EF-hand polypeptides in calmodulin, a natural ubiquitous calcium binding protein that activates the enzymes inv …
The functions of EF-hand proteins from host and zoonotic pathogens.
Zuo W, Tian M, Qi J, Zhang G, Hu J, Wang S, Bao Y. Zuo W, et al. Microbes Infect. 2025 Jan;27(1):105276. doi: 10.1016/j.micinf.2023.105276. Epub 2023 Dec 9. Microbes Infect. 2025. PMID: 38072184 Free article. Review.
EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summarize EF-hand proteins' functions in host and zoonotic pathogens, with details in structures, Ca(2+) affinity, downstream targets …
EF-hand proteins not only regulate biological processes, but also influence immunity and infection. In this review, we summari …
Disrupting polycystin-2 EF hand Ca(2+) affinity does not alter channel function or contribute to polycystic kidney disease.
Vien TN, Ng LCT, Smith JM, Dong K, Krappitz M, Gainullin VG, Fedeles S, Harris PC, Somlo S, DeCaen PG. Vien TN, et al. J Cell Sci. 2020 Dec 24;133(24):jcs255562. doi: 10.1242/jcs.255562. J Cell Sci. 2020. PMID: 33199522 Free PMC article.
Here, we refute the hypothesis that Ca(2+) occupancy of the polycystin-2 intracellular EF hand is responsible for these forms of channel regulation, and, if disrupted, results in ADPKD. We identify and introduce mutations that attenuate Ca(2+)-EF hand …
Here, we refute the hypothesis that Ca(2+) occupancy of the polycystin-2 intracellular EF hand is responsible for these forms …
Tryptophan Scanning Mutagenesis of EF-Hand Motifs.
Kiran U, Kreutz MR, Sharma Y, Chakraborty A. Kiran U, et al. Methods Mol Biol. 2019;1929:567-581. doi: 10.1007/978-1-4939-9030-6_35. Methods Mol Biol. 2019. PMID: 30710297
This chapter describes a method to study various stages during apo to the holo transition of Ca(2+)-binding proteins by Trp-mediated scanning of individual EF-hand motifs. We describe the applicability of this procedure to caldendrin, which is a neuronal Ca(2 …
This chapter describes a method to study various stages during apo to the holo transition of Ca(2+)-binding proteins by Trp-mediated scannin …
Structural insights into the dual Ca2+-sensor-mediated activation of the PPEF phosphatase family.
Liu J, Wu C, Liu Y, Chen Q, Ding Y, Lin Z, Pan L, Xiao K, Li J, Liu Z, Liu W. Liu J, et al. Nat Commun. 2025 Apr 1;16(1):3120. doi: 10.1038/s41467-025-58261-z. Nat Commun. 2025. PMID: 40169586 Free PMC article.
The initially characterized member, Drosophila melanogaster retinal degeneration C (RDGC) contains a calmodulin (CaM)-interacting extended-IQ motif and a Ca(2+)-binding EF-like/EF-hand tandem. However, the molecular regulation of PPEF is poorly understood. .. …
The initially characterized member, Drosophila melanogaster retinal degeneration C (RDGC) contains a calmodulin (CaM)-interacting extended-I …
4,456 results