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2,152 results

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Ca(2+) binding shifts dimeric dual oxidase's truncated EF-hand domain to monomer.
Wei CC, Razzak AA, Ghasemi H, Khedri R, Fraase A. Wei CC, et al. Biophys Chem. 2024 Sep;312:107271. doi: 10.1016/j.bpc.2024.107271. Epub 2024 May 24. Biophys Chem. 2024. PMID: 38852484 Free article.
Duox activation involves Ca(2+) binding to its EF-hand Domain (EFD), which contains two EF-hands (EFs). In this study, we characterized a truncated EFD using spectrometry, calorimetry, electrophoretic mobility, and gel filtration to obtain its Ca(2+) b …
Duox activation involves Ca(2+) binding to its EF-hand Domain (EFD), which contains two EF-hands (EFs). In this …
The EF-hand Ca2+ Binding Domain Is Not Required for Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.
Guo W, Sun B, Xiao Z, Liu Y, Wang Y, Zhang L, Wang R, Chen SR. Guo W, et al. J Biol Chem. 2016 Jan 29;291(5):2150-60. doi: 10.1074/jbc.M115.693325. Epub 2015 Dec 9. J Biol Chem. 2016. PMID: 26663082 Free PMC article.
Although the role of the EF-hand domain in RyR1 function has been studied extensively, little is known about the functional significance of the corresponding EF-hand domain in RyR2. Here we investigate the effect of mutations in the EF …
Although the role of the EF-hand domain in RyR1 function has been studied extensively, little is known about the functi …
Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain.
Enomoto M, Nishikawa T, Back SI, Ishiyama N, Zheng L, Stathopulos PB, Ikura M. Enomoto M, et al. J Mol Biol. 2020 Jan 17;432(2):367-383. doi: 10.1016/j.jmb.2019.10.003. Epub 2019 Oct 15. J Mol Biol. 2020. PMID: 31626806
The trigger for STIM activation is Ca(2+) unbinding from the ER lumen-oriented domains, which consist of a nonconserved amino (N) terminal region and EF-hand and sterile alpha motif (SAM) domains (EF-SAM), highly conserved from humans to Caenorhabditis elegan …
The trigger for STIM activation is Ca(2+) unbinding from the ER lumen-oriented domains, which consist of a nonconserved amino (N) terminal r …
Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Czeta to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).
Nomikos M, Sanders JR, Parthimos D, Buntwal L, Calver BL, Stamatiadis P, Smith A, Clue M, Sideratou Z, Swann K, Lai FA. Nomikos M, et al. J Biol Chem. 2015 Dec 4;290(49):29519-30. doi: 10.1074/jbc.M115.658443. Epub 2015 Oct 1. J Biol Chem. 2015. PMID: 26429913 Free PMC article.
Recently, the PLCdelta1 EF-hand domain was shown to bind to anionic phospholipids through a number of cationic residues, suggesting a potential mechanism for how PLCs might interact with their target membranes. Those critical cationic EF-hand re …
Recently, the PLCdelta1 EF-hand domain was shown to bind to anionic phospholipids through a number of cationic residues …
Structural and functional interactions between the EF hand domain and S2-S3 loop in the type-1 ryanodine receptor ion channel.
Chirasani VR, Elferdink M, Kral M, Carter JS, Heitmann S, Meissner G, Yamaguchi N. Chirasani VR, et al. J Biol Chem. 2024 Feb;300(2):105606. doi: 10.1016/j.jbc.2023.105606. Epub 2023 Dec 28. J Biol Chem. 2024. PMID: 38159862 Free PMC article.
Here, we used molecular dynamics simulations to explore the specific amino acid pairs involved in hydrogen bond interactions within the EF hand-S2-S3 loop interface. Our simulations unveiled two key interactions: (1) K4101 (EF hand) with D4730 (S2-S3 l …
Here, we used molecular dynamics simulations to explore the specific amino acid pairs involved in hydrogen bond interactions within the E …
A high-resolution structure of the EF-hand domain of human polycystin-2.
Allen MD, Qamar S, Vadivelu MK, Sandford RN, Bycroft M. Allen MD, et al. Protein Sci. 2014 Sep;23(9):1301-8. doi: 10.1002/pro.2513. Epub 2014 Jul 22. Protein Sci. 2014. PMID: 24990821 Free PMC article.
The C-terminal cytoplasmic tail contains an EF-hand motif followed by a short coiled-coil domain. We have determined the structure of the EF-hand region of PC-2 using NMR spectroscopy. The use of different boundaries, compared with those used in …
The C-terminal cytoplasmic tail contains an EF-hand motif followed by a short coiled-coil domain. We have determined th …
An AI-informed NMR structure reveals an extraordinary LETM1 F-EF-hand domain that functions as a two-way regulator of mitochondrial calcium.
Lin QT, Colussi DM, Lake T, Stathopulos PB. Lin QT, et al. Structure. 2024 Nov 7;32(11):2063-2082.e5. doi: 10.1016/j.str.2024.08.020. Epub 2024 Sep 23. Structure. 2024. PMID: 39317198 Free article.
AlphaFold can accurately predict static protein structures but does not account for solvent conditions. Human leucine zipper EF-hand transmembrane protein-1 (LETM1) has one sequence-identifiable EF-hand but how calcium (Ca(2+)) affects structure and fu …
AlphaFold can accurately predict static protein structures but does not account for solvent conditions. Human leucine zipper EF-ha …
EF-Hand Mimicking Calcium Binding Polymer.
Chung HJ, Ko du Y, Moon HJ, Jeong B. Chung HJ, et al. Biomacromolecules. 2016 Mar 14;17(3):1075-82. doi: 10.1021/acs.biomac.5b01694. Epub 2016 Mar 2. Biomacromolecules. 2016. PMID: 26909543
There are four EF-hand polypeptides in calmodulin, a natural ubiquitous calcium binding protein that activates the enzymes involved in Ca(2+)-mediated signal transduction. An EF-hand polypeptide has six carboxylate functional groups in the middle loop …
There are four EF-hand polypeptides in calmodulin, a natural ubiquitous calcium binding protein that activates the enzymes inv …
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity.
Petri ET, Celic A, Kennedy SD, Ehrlich BE, Boggon TJ, Hodsdon ME. Petri ET, et al. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9176-81. doi: 10.1073/pnas.0912295107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439752 Free PMC article.
We have previously shown that this tail consists of three functional regions: an EF-hand domain (PC2-EF, 720-797), a flexible linker (798-827), and an oligomeric coiled coil domain (828-895). ...Here we describe the NMR structure and dynamics of …
We have previously shown that this tail consists of three functional regions: an EF-hand domain (PC2-EF, 720-797 …
Structural and functional diversity of EF-hand proteins: Evolutionary perspectives.
Kawasaki H, Kretsinger RH. Kawasaki H, et al. Protein Sci. 2017 Oct;26(10):1898-1920. doi: 10.1002/pro.3233. Epub 2017 Jul 27. Protein Sci. 2017. PMID: 28707401 Free PMC article. Review.
We have classified 865 sequences of EF-hand proteins from five proteomes into 156 subfamilies. These subfamilies were put into six groups. ...These ancestral sequences reveal that some subfamilies in low similarity and isolated groups did not evolve from the EF …
We have classified 865 sequences of EF-hand proteins from five proteomes into 156 subfamilies. These subfamilies were put into …
2,152 results