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170 results

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Page 1
Health Benefits and Chemical Composition of Matcha Green Tea: A Review.
Kochman J, Jakubczyk K, Antoniewicz J, Mruk H, Janda K. Kochman J, et al. Molecules. 2020 Dec 27;26(1):85. doi: 10.3390/molecules26010085. Molecules. 2020. PMID: 33375458 Free PMC article. Review.
Green tea contains four main catechins, i.e., (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG), of which the latter is the most active and abundant and matcha is their best condensed source. ...Due …
Green tea contains four main catechins, i.e., (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epig …
EGCG-like non-competitive inhibitor of DYRK1A rescues cognitive defect in a down syndrome model.
Delabar JM, Gomes MAGB, Fructuoso M, Sarrazin N, George N, Fleary-Roberts N, Sun H, Bui LC, Rodrigues-Lima F, Janel N, Dairou J, Maria EJ, Dodd RH, Cariou K, Potier MC. Delabar JM, et al. Eur J Med Chem. 2024 Feb 5;265:116098. doi: 10.1016/j.ejmech.2023.116098. Epub 2024 Jan 1. Eur J Med Chem. 2024. PMID: 38171148
Epigallocatechin-3-gallate (EGCG) displays appreciable inhibition of DYRK1A activity and, contrary to all other published inhibitors, EGCG is a non-competitive inhibitor of DYRK1A. Prenatal exposure to green tea polyphenols containing EGCG protects from brain …
Epigallocatechin-3-gallate (EGCG) displays appreciable inhibition of DYRK1A activity and, contrary to all other published inhibitors, …
Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice.
Ettcheto M, Cano A, Manzine PR, Busquets O, Verdaguer E, Castro-Torres RD, García ML, Beas-Zarate C, Olloquequi J, Auladell C, Folch J, Camins A. Ettcheto M, et al. Mol Neurobiol. 2020 Apr;57(4):1814-1827. doi: 10.1007/s12035-019-01849-6. Epub 2019 Dec 14. Mol Neurobiol. 2020. PMID: 31838720
Western blot analyses were performed to analyse protein expression, and water maze and novel object recognition test were done to evaluate the cognitive process. EGCG treatment improves peripheral parameters such as insulin sensitivity or liver insulin pathway signa …
Western blot analyses were performed to analyse protein expression, and water maze and novel object recognition test were done to evaluate t …
Prevention of cognitive decline in subjective cognitive decline APOE epsilon4 carriers after EGCG and a multimodal intervention (PENSA): Study design.
Forcano L, Fauria K, Soldevila-Domenech N, Minguillón C, Lorenzo T, Cuenca-Royo A, Menezes-Cabral S, Pizarro N, Boronat A, Molinuevo JL, de la Torre R; PENSA Study Groupǂ. Forcano L, et al. Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12155. doi: 10.1002/trc2.12155. eCollection 2021. Alzheimers Dement (N Y). 2021. PMID: 33816762 Free PMC article.
INTRODUCTION: Subjects exhibiting subjective cognitive decline (SCD) are at an increased risk for mild cognitive impairment and dementia. ...METHODS: The PENSA study is a randomized, double-blind, controlled clinical trial that aims to evaluate the efficacy of a per …
INTRODUCTION: Subjects exhibiting subjective cognitive decline (SCD) are at an increased risk for mild cognitive impairment an …
Increased BBB permeability contributes to EGCG-caused cognitive function improvement in natural aging rats: pharmacokinetic and distribution analyses.
Wei BB, Liu MY, Zhong X, Yao WF, Wei MJ. Wei BB, et al. Acta Pharmacol Sin. 2019 Nov;40(11):1490-1500. doi: 10.1038/s41401-019-0243-7. Epub 2019 May 15. Acta Pharmacol Sin. 2019. PMID: 31092885 Free PMC article.
However, as a water-soluble component, how EGCG exerts its anti-AD effects in the brain was not elucidated. In the present study, we investigated the anti-AD mechanisms of EGCG in natural aging rats with cognitive impairments (CIs) assessed using Morris water …
However, as a water-soluble component, how EGCG exerts its anti-AD effects in the brain was not elucidated. In the present study, we …
Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies.
Alam M, Gulzar M, Akhtar MS, Rashid S, Zulfareen, Tanuja, Shamsi A, Hassan MI. Alam M, et al. Mol Biomed. 2024 Dec 27;5(1):73. doi: 10.1186/s43556-024-00240-9. Mol Biomed. 2024. PMID: 39725830 Free PMC article. Review.
This review provides a comprehensive overview of recent findings on the therapeutic potential of EGCG in various human diseases. Neuroprotective effects of EGCG include safeguarding neurons from damage and enhancing cognitive function, primarily through its a …
This review provides a comprehensive overview of recent findings on the therapeutic potential of EGCG in various human diseases. Neur …
EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS.
Mi Y, Qi G, Fan R, Qiao Q, Sun Y, Gao Y, Liu X. Mi Y, et al. FASEB J. 2017 Nov;31(11):4998-5011. doi: 10.1096/fj.201700400RR. Epub 2017 Jul 24. FASEB J. 2017. PMID: 28739640
Consistent with these results, EGCG attenuated HFFD-induced neuronal damage. Of note, EGCG significantly ameliorated insulin resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT and ERK/cAMP response element binding …
Consistent with these results, EGCG attenuated HFFD-induced neuronal damage. Of note, EGCG significantly ameliorated insulin r …
Neuroprotective and cognitive-enhancing potentials of herbal remedies: Focus on St. John's wort, green tea, and Ashwagandha.
Ahmed M. Ahmed M. Neurotoxicol Teratol. 2025 Sep-Oct;111:107549. doi: 10.1016/j.ntt.2025.107549. Epub 2025 Aug 25. Neurotoxicol Teratol. 2025. PMID: 40865615 Review.
John's Wort has demonstrated potential in alleviating symptoms of depression and anxiety, which are often linked to cognitive decline. Green Tea, rich in polyphenols such as epigallocatechin gallate (EGCG), has shown promise in improving memory function and providin …
John's Wort has demonstrated potential in alleviating symptoms of depression and anxiety, which are often linked to cognitive decline …
Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).
Cieuta-Walti C, Cuenca-Royo A, Langohr K, Rakic C, López-Vílchez MÁ, Lirio J, González-Lamuño Leguina D, González TB, García JG, Roure MR, Aldea-Perona A, Forcano L, Gomis-Gonzalez M, Cés SV, Lacaille F, Ravel A, Mircher C, Walti H, Janel N, Dairou J, Lévy M, Durand S, Dierssen M, Sacco S, Fornell RT; PERSEUS Study Group. Cieuta-Walti C, et al. Genet Med. 2022 Oct;24(10):2004-2013. doi: 10.1016/j.gim.2022.06.011. Epub 2022 Aug 11. Genet Med. 2022. PMID: 35951014 Free article. Clinical Trial.
PURPOSE: Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young adults with Down syndrome (DS), nothing is known about its safety, tolerability, and efficacy in the DS pediatric population. We aimed to e …
PURPOSE: Although some caregivers are using epigallocatechin gallate (EGCG) off label in hopes of improving cognition in young …
Mechanism of Huoshan large-leaf yellow tea in treatment of diabetic cognitive dysfunction based on bioinformatics and network pharmacology.
Li R, Lou Q, Zhu Y, Si M, Zhu X, Jia H, Yang H, Ji T, Xu D, Yang W, Luo S, Wang Y. Li R, et al. Phytomedicine. 2025 Aug;144:156923. doi: 10.1016/j.phymed.2025.156923. Epub 2025 Jun 7. Phytomedicine. 2025. PMID: 40505484
BACKGROUND: Diabetic cognitive dysfunction (DCD) is a prevalent complication of diabetes, characterized by progressive cognitive decline. ...Quercetin, kaempferol, caffeine, theobromine, and EGCG in HLYT exhibited significant binding affinities with these tar …
BACKGROUND: Diabetic cognitive dysfunction (DCD) is a prevalent complication of diabetes, characterized by progressive cognitive …
170 results