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EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer.
Wang X, Reyes ME, Zhang D, Funakoshi Y, Trape AP, Gong Y, Kogawa T, Eckhardt BL, Masuda H, Pirman DA Jr, Yang P, Reuben JM, Woodward WA, Bartholomeusz C, Hortobagyi GN, Tripathy D, Ueno NT. Wang X, et al. Oncotarget. 2017 Jul 4;8(40):67904-67917. doi: 10.18632/oncotarget.18958. eCollection 2017 Sep 15. Oncotarget. 2017. PMID: 28978083 Free PMC article.
Inflammatory breast cancer (IBC) is the most lethal and aggressive type of breast cancer, with a strong proclivity to metastasize, and IBC-specific targeted therapies have not yet been developed. ...Here, we report that EGFR regulates the
Inflammatory breast cancer (IBC) is the most lethal and aggressive type of breast cancer, with a strong p
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.
Singh JK, Simões BM, Howell SJ, Farnie G, Clarke RB. Singh JK, et al. Breast Cancer Res. 2013;15(4):210. doi: 10.1186/bcr3436. Breast Cancer Res. 2013. PMID: 24041156 Free PMC article. Review.
IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastases and is upregulated in HER2-positive cancers. ...Our work demonstrates that in metastatic breast CSCs, CXCR1/2 signals via tran …
IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastases and is …
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