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EIF2S2 transcriptionally upregulates HIF1alpha to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Wang Z, Zhang Y, Xue Y, Huang W, Zhang H. Wang Z, et al. Carcinogenesis. 2024 Dec 30;45(12):916-927. doi: 10.1093/carcin/bgae043. Carcinogenesis. 2024. PMID: 39046731
The promoting role of EIF2S2 in malignant behaviors of gastric cancer cells depended on HIF1alpha expression. Furthermore, the PI3K/AKT/mTOR signaling was activated upon EIF2S2 overexpression in gastric cancer. Collectively, EIF2S2 exacerbates g …
The promoting role of EIF2S2 in malignant behaviors of gastric cancer cells depended on HIF1alpha expression. Furthermore, the …
(18)F-FDG PET/CT metabolic parameters correlate with EIF2S2 expression status in colorectal cancer.
Yang JW, Yuan LL, Gao Y, Liu XS, Wang YJ, Zhou LM, Kui XY, Li XH, Ke CB, Pei ZJ. Yang JW, et al. J Cancer. 2021 Aug 3;12(19):5838-5847. doi: 10.7150/jca.57926. eCollection 2021. J Cancer. 2021. PMID: 34475997 Free PMC article.
We describe the effect of EIF2S2 knockdown on lactate production and the mRNA levels of glycolysis-related genes in human colon cancer SW480 cells. Results: Immunohistochemistry revealed an upregulation of EIF2S2 protein expression in tumor tissues of colorec …
We describe the effect of EIF2S2 knockdown on lactate production and the mRNA levels of glycolysis-related genes in human colon ca …
EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma.
Liu J, Liu T, Zhang C, He J, Zhou D, Wang Z, Wang R. Liu J, et al. Front Genet. 2022 Oct 5;13:992343. doi: 10.3389/fgene.2022.992343. eCollection 2022. Front Genet. 2022. PMID: 36276981 Free PMC article.
We studied the role of EIF2S2 in the malignant progression of liver cancer and its relationship with immune infiltration. ...Drug Sensitivity data from Genomics of Drug Sensitivity in Cancer (GDSC). Results: EIF2S2 is highly expressed in HCC patients a …
We studied the role of EIF2S2 in the malignant progression of liver cancer and its relationship with immune infiltration. ...D …
RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers.
Zhang J, Li S, Zhang L, Xu J, Song M, Shao T, Huang Z, Li Y. Zhang J, et al. Mol Ther. 2020 Apr 8;28(4):1105-1118. doi: 10.1016/j.ymthe.2020.02.004. Epub 2020 Feb 7. Mol Ther. 2020. PMID: 32059763 Free PMC article.
Functional assays performed in cancer cells revealed that EIF2S2 promotes cancer cell proliferation, migration, and invasion in vitro as well as tumor growth and metastasis in vivo. ...Finally, EIF2S2 knockdown combined with oxaliplatin treatment could …
Functional assays performed in cancer cells revealed that EIF2S2 promotes cancer cell proliferation, migration, and inv …
Single cell sequencing analysis and transcriptome analysis constructed the liquid-liquid phase separation(LLPS)-related prognostic model for endometrial cancer.
Wang J, Meng F, Mao F. Wang J, et al. Front Oncol. 2022 Sep 14;12:1005472. doi: 10.3389/fonc.2022.1005472. eCollection 2022. Front Oncol. 2022. PMID: 36185238 Free PMC article.
RESULTS: We created an LLPS-related predictive model for endometrial cancer by extensive study, and it consists of four genes: EIF2S2, SNRPC, PRELID1, and NDUFB9. ...Additionally, there were notable variations in the immunological milieu between the groups at high a …
RESULTS: We created an LLPS-related predictive model for endometrial cancer by extensive study, and it consists of four genes: EIF …
Translation Initiation Factor-2S2 (eIF2S2) Contributes to Cervical Carcinogenesis by Inhibiting the TGF-beta/SMAD4 Signaling Pathway.
Kundu J, Yang H, Moon S, Byun MR, Shin YK, Song K, Choi JS. Kundu J, et al. Biomol Ther (Seoul). 2024 Nov 1;32(6):767-777. doi: 10.4062/biomolther.2024.024. Epub 2024 Oct 7. Biomol Ther (Seoul). 2024. PMID: 39370734 Free PMC article.
The knockdown of eIF2S2 in human cervical cancer (SiHa) cells significantly reduced growth and migration properties, whereas its overexpression demonstrated the opposite effect. ...The interaction effect between eIF2S2 and SMAD4 was further evaluated. The kno …
The knockdown of eIF2S2 in human cervical cancer (SiHa) cells significantly reduced growth and migration properties, whereas i …
Eukaryotic Translation Initiation Factor 2 Subunit beta as a Prognostic Biomarker Associates With Immune Cell Infiltration in Breast Cancer.
Guo M, Ying Y, Chen Y, Miao X, Cui H, Yu Z, Wang X. Guo M, et al. J Surg Res. 2024 Mar;295:753-762. doi: 10.1016/j.jss.2023.11.073. Epub 2023 Dec 25. J Surg Res. 2024. PMID: 38147761
INTRODUCTION: The present study aims to explore the expression level of eukaryotic translation initiation factor 2 subunit beta (EIF2S2) in breast cancer tissue, and its role both in breast cancer prognosis and in the immune microenvironment. ...Taken togethe …
INTRODUCTION: The present study aims to explore the expression level of eukaryotic translation initiation factor 2 subunit beta (EIF2S2 …
Comprehensive Characterization of Ageing-Relevant Subtypes Associated With Different Tumorigenesis and Tumor Microenvironment in Prostate Cancer.
Huang L, Xu Z, Xie Y, Jiang S, Han W, Tang Z, Zhu Q. Huang L, et al. Front Mol Biosci. 2022 Feb 21;9:803474. doi: 10.3389/fmolb.2022.803474. eCollection 2022. Front Mol Biosci. 2022. PMID: 35265669 Free PMC article.
Objective: Accumulated evidence demonstrates that ageing is a robust risk factor of prostate cancer prognosis. Herein, we conducted a systematic analysis about ageing-relevant molecules and relevant tumor microenvironment features in prostate cancer. Methods: Transc …
Objective: Accumulated evidence demonstrates that ageing is a robust risk factor of prostate cancer prognosis. Herein, we conducted a …
Prognostic prediction and gene regulation network of EIF2S2 in hepatocellular carcinoma based on data mining.
Ji P, Wang H, Cheng Y, Liang S. Ji P, et al. J Gastrointest Oncol. 2021 Dec;12(6):3061-3078. doi: 10.21037/jgo-21-748. J Gastrointest Oncol. 2021. PMID: 35070430 Free PMC article.
Eukaryotic translation initiation factor 2 subunit beta (EIF2S2) has reportedly been linked to several tumors, including liver cancer, but the prognostic predictions remain unknown. Therefore, we aimed to clarify the prognostic role and interaction network of EIF …
Eukaryotic translation initiation factor 2 subunit beta (EIF2S2) has reportedly been linked to several tumors, including liver can …
Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice.
Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. Heaney JD, et al. Hum Mol Genet. 2009 Apr 15;18(8):1395-404. doi: 10.1093/hmg/ddp045. Epub 2009 Jan 23. Hum Mol Genet. 2009. PMID: 19168544 Free PMC article.
Here we report that the reduced TGCT incidence of heterozygous A(y) males and the recessive embryonic lethality of A(y) are caused by the deletion of Eif2s2, the beta subunit of translation initiation factor eIF2. We found that the incidence of affected males was reduced 2 …
Here we report that the reduced TGCT incidence of heterozygous A(y) males and the recessive embryonic lethality of A(y) are caused by the de …
24 results