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121 results

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Page 1
IGF2BP2 Drives Cell Cycle Progression in Triple-Negative Breast Cancer by Recruiting EIF4A1 to Promote the m6A-Modified CDK6 Translation Initiation Process.
Xia T, Dai XY, Sang MY, Zhang X, Xu F, Wu J, Shi L, Wei JF, Ding Q. Xia T, et al. Adv Sci (Weinh). 2024 Jan;11(1):e2305142. doi: 10.1002/advs.202305142. Epub 2023 Nov 20. Adv Sci (Weinh). 2024. PMID: 37983610 Free PMC article.
However, its role and related mechanism in breast cancer, especially in triple-negative breast cancer (TNBC), remains unclear. In this study, it is found that IGF2BP2 is highly expressed in TNBC due to the lower methylation level in its promoter region. ...To sum up …
However, its role and related mechanism in breast cancer, especially in triple-negative breast cancer (TNBC), remains unclear. …
Role of eIF4A1 in triple-negative breast cancer stem-like cell-mediated drug resistance.
Raman D, Tiwari AK. Raman D, et al. Cancer Rep (Hoboken). 2022 Dec;5(12):e1299. doi: 10.1002/cnr2.1299. Epub 2020 Oct 14. Cancer Rep (Hoboken). 2022. PMID: 33053607 Free PMC article.
Sridharan et. al. have discovered and provide a novel insight into how eIF4A1 can play a regulatory role in drug resistance by influencing the levels of pluripotent Yamanaka transcription factors and ATP-binding cassette (ABC) transporters in triple-negative breast canc …
Sridharan et. al. have discovered and provide a novel insight into how eIF4A1 can play a regulatory role in drug resistance by influe …
mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells.
Jiao D, Sun H, Zhao X, Chen Y, Lv Z, Shi Q, Li Y, Wang C, Gao K. Jiao D, et al. Elife. 2024 May 13;12:RP92236. doi: 10.7554/eLife.92236. Elife. 2024. PMID: 38738857 Free PMC article.
Enhanced protein synthesis is a crucial molecular mechanism that allows cancer cells to survive, proliferate, metastasize, and develop resistance to anti-cancer treatments, and often arises as a consequence of increased signaling flux channeled to mRNA-bearing eukar …
Enhanced protein synthesis is a crucial molecular mechanism that allows cancer cells to survive, proliferate, metastasize, and develo …
Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
Wang C, Leavenworth J, Zhang C, Liu Z, Yuan KY, Wang Y, Zhang G, Wang S, Cui X, Zhang Y, Bae S, Zhou J, Wang L, Liu R. Wang C, et al. Oncogene. 2022 May;41(19):2778-2785. doi: 10.1038/s41388-022-02272-3. Epub 2022 Mar 31. Oncogene. 2022. PMID: 35361883 Free PMC article.
By the use of human specimens and cell models, we addressed the role of eIF4A1 in prostate cancer in vitro and in vivo. EIF4A1 expression, as determined by mRNA and protein levels, was higher in primary prostate cancers relative to normal prostate tiss …
By the use of human specimens and cell models, we addressed the role of eIF4A1 in prostate cancer in vitro and in vivo. EIF …
MiR-1284 suppresses gastric cancer progression by targeting EIF4A1.
Wei W, Cao W, Zhan Z, Yan L, Xie Y, Xiao Q. Wei W, et al. Onco Targets Ther. 2019 May 21;12:3965-3976. doi: 10.2147/OTT.S191015. eCollection 2019. Onco Targets Ther. 2019. PMID: 31190893 Free PMC article.
MiR-1284 also suppressed tumor from growing and metastasizing in xenograft models as well as influenced the gene expression profile in SGC-7901 cells. Also, EIF4A1 was the direct target gene for miR-1284. Further, an inverse correlation between the miR-1284 expression and …
MiR-1284 also suppressed tumor from growing and metastasizing in xenograft models as well as influenced the gene expression profile in SGC-7 …
Targeted intervention of eIF4A1 inhibits EMT and metastasis of pancreatic cancer cells via c-MYC/miR-9 signaling.
Zhao Y, Wang Y, Chen W, Bai S, Peng W, Zheng M, Yang Y, Cheng B, Luan Z. Zhao Y, et al. Cancer Cell Int. 2021 Dec 14;21(1):670. doi: 10.1186/s12935-021-02390-0. Cancer Cell Int. 2021. PMID: 34906136 Free PMC article.
Expression regulation and pharmacological inhibition of eIF4A1 and c-MYC were performed to determine their role in migration, invasion, and metastasis in pancreatic cancer cells in vitro and in vivo. ...Loss of eIF4A1 and c-MYC decreased the EMT and metastasi …
Expression regulation and pharmacological inhibition of eIF4A1 and c-MYC were performed to determine their role in migration, invasio …
RNA helicase EIF4A1-mediated translation is essential for the GC response.
Screen M, Matheson LS, Howden AJ, Strathdee D, Willis AE, Bushell M, Sansom O, Turner M. Screen M, et al. Life Sci Alliance. 2023 Nov 27;7(2):e202302301. doi: 10.26508/lsa.202302301. Print 2024 Feb. Life Sci Alliance. 2023. PMID: 38011999 Free PMC article.
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability to promote the translation of oncogenes with structured 5' untranslated regions. ...However, EIF4A1-deficient cells remain viable, w …
EIF4A1 and cofactors EIF4B and EIF4H have been well characterised in cancers, including B cell malignancies, for their ability …
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Gao C, Guo X, Xue A, Ruan Y, Wang H, Gao X. Gao C, et al. Acta Biochim Biophys Sin (Shanghai). 2020 Mar 18;52(3):310-319. doi: 10.1093/abbs/gmz168. Acta Biochim Biophys Sin (Shanghai). 2020. PMID: 32147684 Free article.
However, the role of eIF4A1 in gastric cancer progression remains unclear. In this study, we found that the expression of eIF4A1, a component of translation initiation complex, was increased in gastric cancer. ...Together, these findings indicate that …
However, the role of eIF4A1 in gastric cancer progression remains unclear. In this study, we found that the expression of e …
Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
Ma X, Li B, Liu J, Fu Y, Luo Y. Ma X, et al. J Exp Clin Cancer Res. 2019 Feb 11;38(1):66. doi: 10.1186/s13046-019-1053-y. J Exp Clin Cancer Res. 2019. PMID: 30744688 Free PMC article.
BACKGROUND: Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types. ...CONCLUSION: Besides catalyzing serine synthesis, PHGDH promotes pancreatic cancer develo …
BACKGROUND: Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, th …
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
Modelska A, Turro E, Russell R, Beaton J, Sbarrato T, Spriggs K, Miller J, Gräf S, Provenzano E, Blows F, Pharoah P, Caldas C, Le Quesne J. Modelska A, et al. Cell Death Dis. 2015 Jan 22;6(1):e1603. doi: 10.1038/cddis.2014.542. Cell Death Dis. 2015. PMID: 25611378 Free PMC article.
We found eIF4A1, eIF4B and eIF4E to be independent predictors of poor outcome in ER-negative disease, while in contrast, the eIF4A1 inhibitor PDCD4 was related to improved outcome in ER-positive breast cancer. Consistent with these data, modulation of eIF4 …
We found eIF4A1, eIF4B and eIF4E to be independent predictors of poor outcome in ER-negative disease, while in contrast, the eIF4A …
121 results