Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.
Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L.
Tang Y, et al.
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50. doi: 10.1073/pnas.0705395105. Epub 2008 Feb 8.
Proc Natl Acad Sci U S A. 2008.
PMID: 18263735
Free PMC article.
Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between specific signaling pathways in solid organ "cancer stem cells," such as those of the liver, remain …
Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet funct …