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1990 1
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2001 37
2002 42
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2005 42
2006 25
2007 51
2008 46
2009 74
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2012 71
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2,501 results

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Page 1
EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.
Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J. Durbin AD, et al. Cancer Discov. 2022 Mar 1;12(3):730-751. doi: 10.1158/2159-8290.CD-21-0385. Cancer Discov. 2022. PMID: 34772733 Free PMC article.
We demonstrate that the majority of high-risk pediatric neuroblastoma (NB) depends on EP300, whereas CBP has a limited role. EP300 controls enhancer acetylation by interacting with TFAP2beta, a transcription factor member of the lineage-defining transcriptional core …
We demonstrate that the majority of high-risk pediatric neuroblastoma (NB) depends on EP300, whereas CBP has a limited role. EP300 …
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.
Nicosia L, Spencer GJ, Brooks N, Amaral FMR, Basma NJ, Chadwick JA, Revell B, Wingelhofer B, Maiques-Diaz A, Sinclair O, Camera F, Ciceri F, Wiseman DH, Pegg N, West W, Knurowski T, Frese K, Clegg K, Campbell VL, Cavet J, Copland M, Searle E, Somervaille TCP. Nicosia L, et al. Cancer Cell. 2023 Dec 11;41(12):2136-2153.e13. doi: 10.1016/j.ccell.2023.11.001. Epub 2023 Nov 22. Cancer Cell. 2023. PMID: 37995682 Free article.
CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems. ...Thus, CCS1477 exhibits encouraging preclinical and early-phase clinical activity by disrupting recruit …
CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hem …
EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs.
Rubio K, Molina-Herrera A, Pérez-González A, Hernández-Galdámez HV, Piña-Vázquez C, Araujo-Ramos T, Singh I. Rubio K, et al. Int J Mol Sci. 2023 Aug 1;24(15):12302. doi: 10.3390/ijms241512302. Int J Mol Sci. 2023. PMID: 37569677 Free PMC article. Review.
Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. ...We also highlight the contributions of small molecule inhibitors and gene therapy approaches targeting EP300 as novel therapies aga …
Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. . …
Recent Advances in CBP/EP300 Degraders.
Palaferri L, Cheng-Sánchez I, Nevado C. Palaferri L, et al. Chimia (Aarau). 2025 Mar 26;79(3):137-145. doi: 10.2533/chimia.2025.137. Chimia (Aarau). 2025. PMID: 40156557 Free article. Review.
In recent years, extensive research has focused on developing degraders targeting CREB-binding protein (CBP) and E1A-associated protein (EP300) - two homologous multidomain enzymes critical for enhancer-mediated transcription. This review explores the state of the art in C …
In recent years, extensive research has focused on developing degraders targeting CREB-binding protein (CBP) and E1A-associated protein ( …
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM, Zhao WL. Huang YH, et al. Signal Transduct Target Ther. 2021 Jan 11;6(1):10. doi: 10.1038/s41392-020-00437-8. Signal Transduct Target Ther. 2021. PMID: 33431788 Free PMC article.
Among all 619 DLBCL patients, somatic mutations in KMT2D (19.5%) were most frequently observed, followed by mutations in ARID1A (8.7%), CREBBP (8.4%), KMT2C (8.2%), TET2 (7.8%), EP300 (6.8%), and EZH2 (2.9%). Among them, CREBBP/EP300 mutations were significantly ass …
Among all 619 DLBCL patients, somatic mutations in KMT2D (19.5%) were most frequently observed, followed by mutations in ARID1A (8.7%), CREB …
HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis.
Emmons MF, Bennett RL, Riva A, Gupta K, Carvalho LADC, Zhang C, Macaulay R, Dupéré-Richér D, Fang B, Seto E, Koomen JM, Li J, Chen YA, Forsyth PA, Licht JD, Smalley KSM. Emmons MF, et al. Nat Commun. 2023 Nov 29;14(1):7759. doi: 10.1038/s41467-023-43519-1. Nat Commun. 2023. PMID: 38030596 Free PMC article.
Functionally, HDAC8 deacetylates the histone acetyltransferase EP300, causing its enzymatic inactivation. This, in turn, increases binding of EP300 to Jun-transcriptional sites and decreases binding to MITF-transcriptional sites. Inhibition of EP300 increases …
Functionally, HDAC8 deacetylates the histone acetyltransferase EP300, causing its enzymatic inactivation. This, in turn, increases bi …
CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population.
Tauziède-Espariat A, Uro-Coste E, Sievers P, Nicaise Y, Mariet C, Siegfried A, Pierron G, Guillemot D, Benzakoun J, Pallud J, Roques M, Bonneville F, Larrieu-Ciron D, Chaynes P, Saffroy R, Hamelin J, Hasty L, Métais A, Chrétien F, Kool M, Gojo J, Varlet P; RENOCLIP-LOC. Tauziède-Espariat A, et al. Acta Neuropathol Commun. 2023 Feb 13;11(1):26. doi: 10.1186/s40478-023-01523-y. Acta Neuropathol Commun. 2023. PMID: 36782314 Free PMC article. Review.
Herein, we present two adult cases of CNS tumors with EP300::BCOR fusion. These two cases presented radiological, histopathological, and immunohistochemical homologies with CNS tumors having BCOR ITD in children. ...CNS tumors from the EP300::BCOR fusion methylation …
Herein, we present two adult cases of CNS tumors with EP300::BCOR fusion. These two cases presented radiological, histopathological, …
EP300 facilitates human trophoblast stem cell differentiation.
van Voorden AJ, Keijser R, Veenboer GJM, Lopes Cardozo SA, Diek D, Vlaardingerbroek JA, van Dijk M, Ris-Stalpers C, van Pelt AMM, Afink GB. van Voorden AJ, et al. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2217405120. doi: 10.1073/pnas.2217405120. Epub 2023 Jul 5. Proc Natl Acad Sci U S A. 2023. PMID: 37406095 Free PMC article.
The incidence of these complications is increased in pregnancies of fetuses affected by Rubinstein-Taybi syndrome, a developmental disorder predominantly caused by heterozygous mutations in CREB-binding protein (CREBBP) or E1A-binding protein p300 (EP300). Although the ace …
The incidence of these complications is increased in pregnancies of fetuses affected by Rubinstein-Taybi syndrome, a developmental disorder …
EP300 compromises antitumor immunity by increasing SOCS1 expression.
Zeng Y, Zhou Y, Ruan J, Liu W, Fan H, Liu N, Li L, Ma J, Jin X, Duan L, Chen Y, Cheng G, Yang H. Zeng Y, et al. J Immunother Cancer. 2025 Oct 15;13(10):e011488. doi: 10.1136/jitc-2025-011488. J Immunother Cancer. 2025. PMID: 41093624 Free PMC article.
METHODS: We analyzed tissue microarrays from patients with lung adenocarcinoma using immunohistochemistry to compare EP300 expression between cancerous tissues and benign tissues. Ep300-knockout cancer cells were generated using CRISPR-Cas9. ...RESULTS: EP300 …
METHODS: We analyzed tissue microarrays from patients with lung adenocarcinoma using immunohistochemistry to compare EP300 expression …
Epigenetic Activation of the CMTM6-IGF2BP1-EP300 Positive Feedback Loop Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma.
Zhu YQ, Huang Y, Shi YH, Huang CS, Zhao GY, Liu ZD, Ma MJ, Ye JY, Xu X, Liu Q, Huang XT, Wang JQ, Xu QC, Yin XY. Zhu YQ, et al. Adv Sci (Weinh). 2024 Dec;11(47):e2406714. doi: 10.1002/advs.202406714. Epub 2024 Nov 3. Adv Sci (Weinh). 2024. PMID: 39488785 Free PMC article.
The m(6)A reader IGF2BP1 stabilizes the EP300 and MYC mRNAs by recognizing m(6)A modifications, forming a positive feedback loop that enhances tumor stemness and ultimately contributes to PDAC resistance. The combined application of the EP300 inhibitor inobrodib and …
The m(6)A reader IGF2BP1 stabilizes the EP300 and MYC mRNAs by recognizing m(6)A modifications, forming a positive feedback loop that …
2,501 results