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1,041 results

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Page 1
Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial.
Nicholls SJ, Lincoff AM, Garcia M, Bash D, Ballantyne CM, Barter PJ, Davidson MH, Kastelein JJP, Koenig W, McGuire DK, Mozaffarian D, Ridker PM, Ray KK, Katona BG, Himmelmann A, Loss LE, Rensfeldt M, Lundström T, Agrawal R, Menon V, Wolski K, Nissen SE. Nicholls SJ, et al. JAMA. 2020 Dec 8;324(22):2268-2280. doi: 10.1001/jama.2020.22258. JAMA. 2020. PMID: 33190147 Free PMC article. Clinical Trial.
IMPORTANCE: It remains uncertain whether the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce cardiovascular risk. OBJECTIVE: To determine the effects on cardiovascular outcomes of a carboxylic acid formulation of EPA and …
IMPORTANCE: It remains uncertain whether the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) re …
Omega-3-fatty acids: Do they prevent cardiovascular disease?
Mason RP, Sherratt SCR, Eckel RH. Mason RP, et al. Best Pract Res Clin Endocrinol Metab. 2023 May;37(3):101681. doi: 10.1016/j.beem.2022.101681. Epub 2022 Jun 3. Best Pract Res Clin Endocrinol Metab. 2023. PMID: 35739003 Free article. Review.
Alongside low-density lipoproteins (LDL-C), elevated triglycerides (TG) are associated with incident CVD events. Omega-3 fatty acids (n3-FAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower TG levels, but their ability to reduc …
Alongside low-density lipoproteins (LDL-C), elevated triglycerides (TG) are associated with incident CVD events. Omega-3 fatty acids …
Role of Omega-3 Fatty Acids in Cardiovascular Disease: the Debate Continues.
Sherratt SCR, Libby P, Budoff MJ, Bhatt DL, Mason RP. Sherratt SCR, et al. Curr Atheroscler Rep. 2023 Jan;25(1):1-17. doi: 10.1007/s11883-022-01075-x. Epub 2022 Dec 29. Curr Atheroscler Rep. 2023. PMID: 36580204 Free PMC article. Review.
In particular, CV trials using icosapent ethyl (IPE), a highly purified ethyl ester of EPA, reproducibly reduced CV events and progression of atherosclerosis compared with mixed EPA/DHA treatments. ...Multiple trials using mixed EPA/DHA formulat …
In particular, CV trials using icosapent ethyl (IPE), a highly purified ethyl ester of EPA, reproducibly reduced CV events and progre …
Clinical Management of Hypertriglyceridemia in the Prevention of Cardiovascular Disease and Pancreatitis.
Hernandez P, Passi N, Modarressi T, Kulkarni V, Soni M, Burke F, Bajaj A, Soffer D. Hernandez P, et al. Curr Atheroscler Rep. 2021 Sep 13;23(11):72. doi: 10.1007/s11883-021-00962-z. Curr Atheroscler Rep. 2021. PMID: 34515873 Free PMC article. Review.
However, treatment with eicosapentaenoic acid (EPA) combined with docosahexanoic acid (DHA) did not reduce ASCVD in a similar population studied in the STRENGTH trial. ...The findings from REDUCE-IT, but not STRENGTH, confirm that consumption of high-dose EPA …
However, treatment with eicosapentaenoic acid (EPA) combined with docosahexanoic acid (DHA) did not reduce ASCVD in a similar …
Bioavailability of marine n-3 fatty acid formulations.
Dyerberg J, Madsen P, Møller JM, Aardestrup I, Schmidt EB. Dyerberg J, et al. Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):137-41. doi: 10.1016/j.plefa.2010.06.007. Prostaglandins Leukot Essent Fatty Acids. 2010. PMID: 20638827 Clinical Trial.
Seventy-two volunteers were given approximately 3.3g of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) daily for 2 weeks. Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterol esters and phospholip …
Seventy-two volunteers were given approximately 3.3g of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) daily for …
Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
Lu J, Liu R, Ren H, Wang S, Hu C, Shi Z, Li M, Liu W, Wan Q, Su Q, Li Q, Zheng H, Qu S, Yang F, Ji H, Lin H, Qi H, Wu X, Wu K, Chen Y, Xu Y, Xu M, Wang T, Zheng J, Ning G, Zheng R, Bi Y, Zhong H, Wang W. Lu J, et al. Med. 2025 Jan 10;6(1):100496. doi: 10.1016/j.medj.2024.07.024. Epub 2024 Aug 19. Med. 2025. PMID: 39163858 Free article. Clinical Trial.
BACKGROUND: Fish oil (FO), a mixture of omega-3 fatty acids mainly comprising docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), has been recommended for patients with type 2 diabetes (T2D) and hypertriglyceridemia. ...FO significantly altered the serum lip …
BACKGROUND: Fish oil (FO), a mixture of omega-3 fatty acids mainly comprising docosahexaenoic acid (DHA) and eicosapentaenoic acid ( …
Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association.
Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, Richter CK, Jacobson TA, Engler MB, Miller M, Robinson JG, Blum CB, Rodriguez-Leyva D, de Ferranti SD, Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. Skulas-Ray AC, et al. Circulation. 2019 Sep 17;140(12):e673-e691. doi: 10.1161/CIR.0000000000000709. Epub 2019 Aug 19. Circulation. 2019. PMID: 31422671 Free article.
The purpose of this advisory is to summarize the lipid and lipoprotein effects resulting from pharmacological doses of n-3 FAs (>3 g/d total EPA+DHA) on the basis of new scientific data and availability of n-3 FA agents. In treatment of very high triglycerides …
The purpose of this advisory is to summarize the lipid and lipoprotein effects resulting from pharmacological doses of n-3 FAs (>3 g/d to …
Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain( ).
Manual Kollareth DJ, Deckelbaum RJ, Liu Z, Ramakrishnan R, Jouvene C, Serhan CN, Ten VS, Zirpoli H. Manual Kollareth DJ, et al. Prostaglandins Leukot Essent Fatty Acids. 2020 Nov;162:102176. doi: 10.1016/j.plefa.2020.102176. Epub 2020 Sep 25. Prostaglandins Leukot Essent Fatty Acids. 2020. PMID: 33038830 Free PMC article.
Furthermore, increases in EPA and EPA-derived SPMs following tri-DHA injection demonstrate interlinked metabolism of these two fatty acids. Hence, changes in both EPA and DHA profile patterns need to be considered when studying the protective ef …
Furthermore, increases in EPA and EPA-derived SPMs following tri-DHA injection demonstrate interlinked metabolism of th …
Evaluation of Marine Microorganism-Derived Oils Containing EPA and DHA for Triglyceride Improvement and Blood Circulation Enhancement.
Yin TY, Rho JR, Yoo YD, Jeong EJ, Park J, Yoon EY. Yin TY, et al. J Microbiol Biotechnol. 2025 Apr 9;35:e2412009. doi: 10.4014/jmb.2412.12009. J Microbiol Biotechnol. 2025. PMID: 40223248 Free PMC article.
In this study, we explore the potential of marine Microorganism-derived oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in addressing these physiological phenomena associated with CVDs. ...In this study, we evaluated the efficacy of EPA …
In this study, we explore the potential of marine Microorganism-derived oils rich in eicosapentaenoic acid (EPA) and docosahexaenoic …
EPA/DHA and linseed oil have different effects on liver and adipose tissue in rats fed with a high-fat diet.
Dias BV, Gomes SV, Castro MLDC, Carvalho LCF, Breguez GS, de Souza DMS, Ramos CO, Sant'Ana MR, Nakandakari SCBR, Araujo CM, Grabe-Guimarães A, Talvani A, Carneiro CM, Cintra DEC, Costa DC. Dias BV, et al. Prostaglandins Other Lipid Mediat. 2022 Apr;159:106622. doi: 10.1016/j.prostaglandins.2022.106622. Epub 2022 Jan 25. Prostaglandins Other Lipid Mediat. 2022. PMID: 35091082
Our objective was to evaluate the effect of treatment with linseed oil, a vegetable oil rich in alpha-linolenic acid, and EPA and DHA in different proportions (3:1 EPA:DHA, and 1:3 EPA:DHA), on the metabolic disorders induced by a high-fa …
Our objective was to evaluate the effect of treatment with linseed oil, a vegetable oil rich in alpha-linolenic acid, and EPA and …
1,041 results