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92 results

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Page 1
ERK/MAPK signalling in the developing brain: Perturbations and consequences.
Iroegbu JD, Ijomone OK, Femi-Akinlosotu OM, Ijomone OM. Iroegbu JD, et al. Neurosci Biobehav Rev. 2021 Dec;131:792-805. doi: 10.1016/j.neubiorev.2021.10.009. Epub 2021 Oct 8. Neurosci Biobehav Rev. 2021. PMID: 34634357 Review.
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK) signalling pathway transduces signals that cause an alteration in the ongoing metabolic pathways and modifies gene expression patterns; thus, influencing cellular behaviour. . …
The extracellular regulated kinase/microtubule-associated protein kinase (ERK/MAPK) signalling pathway transduces signa …
Elucidation of Abnormal Extracellular Regulated Kinase (ERK) Signaling and Associations with Syndromic and Non-syndromic Autism.
Tiwari A, Rahi S, Mehan S. Tiwari A, et al. Curr Drug Targets. 2021;22(9):1071-1086. doi: 10.2174/1389450121666201020155010. Curr Drug Targets. 2021. PMID: 33081671 Review.
The precise etiology of Autism Spectrum Disorder (ASD) is currently unclear. The extracellular signal-regulated kinase (ERK) signaling mechanism affects neurogenesis and neuronal plasticity during the development of the central nervous mechanism. ...In …
The precise etiology of Autism Spectrum Disorder (ASD) is currently unclear. The extracellular signal-regulated kinase …
ERK/MAPK signaling and autism spectrum disorders.
Vithayathil J, Pucilowska J, Landreth GE. Vithayathil J, et al. Prog Brain Res. 2018;241:63-112. doi: 10.1016/bs.pbr.2018.09.008. Epub 2018 Nov 1. Prog Brain Res. 2018. PMID: 30447757 Review.
Recently, it has been appreciated that these disorders are associated with autism spectrum disorders (ASD). In addition, idiopathic ASD has also implicated the MAPK signaling cascade as a common pathway that is affected by many of the genetic variants that have been found …
Recently, it has been appreciated that these disorders are associated with autism spectrum disorders (ASD). In addition, idiopathic A …
Potential opposite roles of the extracellular signal-regulated kinase (ERK) pathway in autism spectrum and bipolar disorders.
Kalkman HO. Kalkman HO. Neurosci Biobehav Rev. 2012 Nov;36(10):2206-13. doi: 10.1016/j.neubiorev.2012.07.008. Epub 2012 Aug 4. Neurosci Biobehav Rev. 2012. PMID: 22884480 Review.
Signal transduction from the synapse to the nucleus subsequently involves transient increases in synaptic Ca2+, activation of CaM kinases, activation of the GTPase Ras, activation of the ERK mitogen-activated protein kinase pathway, and finally GSK3 inhibitio …
Signal transduction from the synapse to the nucleus subsequently involves transient increases in synaptic Ca2+, activation of CaM kinases …
MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes.
Albert-Gascó H, Ros-Bernal F, Castillo-Gómez E, Olucha-Bordonau FE. Albert-Gascó H, et al. Int J Mol Sci. 2020 Jun 23;21(12):4471. doi: 10.3390/ijms21124471. Int J Mol Sci. 2020. PMID: 32586047 Free PMC article. Review.
The signaling pathway of the microtubule-associated protein kinase or extracellular regulated kinase (MAPK/ERK) is a common mechanism of extracellular information transduction from extracellular stimuli to the intracellular space. ...Alterations in mechanisms …
The signaling pathway of the microtubule-associated protein kinase or extracellular regulated kinase (MAPK/ERK) is a co …
Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network.
D'Incal C, Broos J, Torfs T, Kooy RF, Vanden Berghe W. D'Incal C, et al. Cells. 2022 Apr 13;11(8):1325. doi: 10.3390/cells11081325. Cells. 2022. PMID: 35456004 Free PMC article. Review.
Studies have indicated the involvement of FMRP in a multitude of cellular pathways, and an absence of FMRP was shown to affect several neurotransmitter receptors, for example, the GABA receptor and intracellular signaling molecules such as Akt, ERK, mTOR, and GSK3. Interes …
Studies have indicated the involvement of FMRP in a multitude of cellular pathways, and an absence of FMRP was shown to affect several neuro …
A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism.
Murari K, Abushaibah A, Rho JM, Turner RW, Cheng N. Murari K, et al. EBioMedicine. 2023 May;91:104565. doi: 10.1016/j.ebiom.2023.104565. Epub 2023 Apr 21. EBioMedicine. 2023. PMID: 37088035 Free PMC article.
BACKGROUND: Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is hypothesized to be a critical convergent node in the development of autism spectrum disorder. ...These results suggest that a similar approach could be applied to anim …
BACKGROUND: Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is hypothesized to be a critical convergent …
p21 protein-activated kinase 1 is associated with severe regressive autism, and epilepsy.
Kernohan KD, McBride A, Hartley T, Rojas SK; Care4Rare Canada Consortium; Dyment DA, Boycott KM, Dyack S. Kernohan KD, et al. Clin Genet. 2019 Nov;96(5):449-455. doi: 10.1111/cge.13618. Epub 2019 Aug 13. Clin Genet. 2019. PMID: 31392718
The p21-activated kinase (PAK) family of proteins function as key effectors of RHO family GTPases in mammalian cells to regulate many pathways including Ras/Raf/MEK/ERK and Wnt/beta-catenin, amongst others. Here we report an individual with a novel autosomal dominan …
The p21-activated kinase (PAK) family of proteins function as key effectors of RHO family GTPases in mammalian cells to regulate many …
Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus.
Hu HT, Lin YJ, Wang UT, Lee SP, Liou YH, Chen BC, Hsueh YP. Hu HT, et al. PLoS Biol. 2023 Aug 31;21(8):e3002274. doi: 10.1371/journal.pbio.3002274. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37651441 Free PMC article.
Both KLHL17 and SYNPO are F-actin-binding proteins linked to autism. SYNPO is known to maintain the structure of the spine apparatus in mature spines and contributes to synaptic plasticity. ...Accordingly, activity-dependent dendritic spine enlargement and neuronal activat …
Both KLHL17 and SYNPO are F-actin-binding proteins linked to autism. SYNPO is known to maintain the structure of the spine apparatus …
Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism.
Cheng N, Alshammari F, Hughes E, Khanbabaei M, Rho JM. Cheng N, et al. PLoS One. 2017 Jun 13;12(6):e0179409. doi: 10.1371/journal.pone.0179409. eCollection 2017. PLoS One. 2017. PMID: 28609458 Free PMC article.
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental condition characterized by impaired social communication and interactions, and restricted, repetitive activities or interests. ...Biochemical analysis further showed that …
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental condition characterized by imp …
92 results