ES09122/ES/NIEHS NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
1998	1
2000	1
2001	3
2002	1
2005	1
2007	3
2022	0

1

Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites.

Ekins S, de Groot MJ, Jones JP. Ekins S, et al. Drug Metab Dispos. 2001 Jul;29(7):936-44. Drug Metab Dispos. 2001. PMID: 11408357 Review.

2

Three-dimensional quantitative structure-activity relationship analysis of cytochromes p450: effect of incorporating higher-affinity ligands and potential new applications.

Locuson CW, Wahlstrom JL. Locuson CW, et al. Drug Metab Dispos. 2005 Jul;33(7):873-8. doi: 10.1124/dmd.105.004325. Epub 2005 Apr 20. Drug Metab Dispos. 2005. PMID: 15843486 Review.

3

Empirical regioselectivity models for human cytochromes P450 3A4, 2D6, and 2C9.

Sheridan RP, Korzekwa KR, Torres RA, Walker MJ. Sheridan RP, et al. J Med Chem. 2007 Jul 12;50(14):3173-84. doi: 10.1021/jm0613471. Epub 2007 Jun 19. J Med Chem. 2007. PMID: 17579382 Free PMC article.

4

An assessment of the reaction energetics for cytochrome P450-mediated reactions.

Higgins L, Korzekwa KR, Rao S, Shou M, Jones JP. Higgins L, et al. Arch Biochem Biophys. 2001 Jan 1;385(1):220-30. doi: 10.1006/abbi.2000.2147. Arch Biochem Biophys. 2001. PMID: 11361021

5

Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like molecules.

McMasters DR, Torres RA, Crathern SJ, Dooney DL, Nachbar RB, Sheridan RP, Korzekwa KR. McMasters DR, et al. J Med Chem. 2007 Jul 12;50(14):3205-13. doi: 10.1021/jm0700060. Epub 2007 Jun 9. J Med Chem. 2007. PMID: 17559204 Free PMC article.

6

Use of density functional calculations to predict the regioselectivity of drugs and molecules metabolized by aldehyde oxidase.

Torres RA, Korzekwa KR, McMasters DR, Fandozzi CM, Jones JP. Torres RA, et al. J Med Chem. 2007 Sep 20;50(19):4642-7. doi: 10.1021/jm0703690. Epub 2007 Aug 25. J Med Chem. 2007. PMID: 17718551

7

Evaluation of cytochrome P450 mechanism and kinetics using kinetic deuterium isotope effects.

Higgins L, Bennett GA, Shimoji M, Jones JP. Higgins L, et al. Biochemistry. 1998 May 12;37(19):7039-46. doi: 10.1021/bi9729864. Biochemistry. 1998. PMID: 9578592

8

A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions.

Rao S, Aoyama R, Schrag M, Trager WF, Rettie A, Jones JP. Rao S, et al. J Med Chem. 2000 Jul 27;43(15):2789-96. doi: 10.1021/jm000048n. J Med Chem. 2000. PMID: 10956186

9

Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

Christmas P, Jones JP, Patten CJ, Rock DA, Zheng Y, Cheng SM, Weber BM, Carlesso N, Scadden DT, Rettie AE, Soberman RJ. Christmas P, et al. J Biol Chem. 2001 Oct 12;276(41):38166-72. doi: 10.1074/jbc.M104818200. Epub 2001 Jul 18. J Biol Chem. 2001. PMID: 11461919 Free article.

10

Active site mutations of cytochrome p450cam alter the binding, coupling, and oxidation of the foreign substrates (R)- and (s)-2-ethylhexanol.

French KJ, Rock DA, Rock DA, Manchester JI, Goldstein BM, Jones JP. French KJ, et al. Arch Biochem Biophys. 2002 Feb 15;398(2):188-97. doi: 10.1006/abbi.2001.2732. Arch Biochem Biophys. 2002. PMID: 11831849

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