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2005 1
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Page 1
Genetically engineered ERα-positive breast cancer mouse models.
Dabydeen SA, Furth PA. Dabydeen SA, et al. Endocr Relat Cancer. 2014 May 6;21(3):R195-208. doi: 10.1530/ERC-13-0512. Print 2014 Jun. Endocr Relat Cancer. 2014. PMID: 24481326 Free PMC article. Review.
Where available, information on cancer pathology and gene expression profiles is referenced to assist in understanding which histological subtype of ER+ human cancer each model might represent. ESR1, CCDN1, prolactin, TGFalpha, AIB1, ESPL1, and WNT1 overexpression, PIK3CA …
Where available, information on cancer pathology and gene expression profiles is referenced to assist in understanding which histological su …
The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes.
Grimaldi AM, Conte F, Pane K, Fiscon G, Mirabelli P, Baselice S, Giannatiempo R, Messina F, Franzese M, Salvatore M, Paci P, Incoronato M. Grimaldi AM, et al. Int J Mol Sci. 2020 Sep 12;21(18):6690. doi: 10.3390/ijms21186690. Int J Mol Sci. 2020. PMID: 32932728 Free PMC article.
Results showed that four of these hub proteins (AURKA, CDC45, ESPL1, and RAD54L) were over-expressed in all tumor subtypes. Moreover, the inhibition of one of the identified switch genes (AURKA) similarly affected all BC subtypes. ...
Results showed that four of these hub proteins (AURKA, CDC45, ESPL1, and RAD54L) were over-expressed in all tumor subtypes. Moreover, …
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer.
Buechler SA, Gökmen-Polar Y, Badve SS. Buechler SA, et al. Clin Breast Cancer. 2019 Feb;19(1):17-26.e8. doi: 10.1016/j.clbc.2018.07.011. Epub 2018 Jul 17. Clin Breast Cancer. 2019. PMID: 30097312 Free article.
RESULTS: The EarlyR score and categorical risk strata (EarlyR-Low, EarlyR-Int, EarlyR-High) derived from expression of ESPL1, MKI67, SPAG5, PLK1 and PGR was prognostic of 8-year distant recurrence-free interval in Affymetrix (categorical P = 3.5 10(-14); continuous P = 8.8 …
RESULTS: The EarlyR score and categorical risk strata (EarlyR-Low, EarlyR-Int, EarlyR-High) derived from expression of ESPL1, MKI67, …
EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer.
Buechler SA, Gökmen-Polar Y, Badve SS. Buechler SA, et al. Breast. 2019 Feb;43:74-80. doi: 10.1016/j.breast.2018.11.006. Epub 2018 Nov 17. Breast. 2019. PMID: 30502641
BACKGROUND: EarlyR gene signature uses ESPL1, SPAG5, MKI67, PLK1 and PGR to classify ER+ breast cancer (ER+ BC) into EarlyR-Low, EarlyR-Int, and EarlyR-High risk strata and is prognostic in patients treated with adjuvant chemotherapy. ...
BACKGROUND: EarlyR gene signature uses ESPL1, SPAG5, MKI67, PLK1 and PGR to classify ER+ breast cancer (ER+ BC) into EarlyR-Low, Earl …
Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention.
Koedoot E, van Steijn E, Vermeer M, González-Prieto R, Vertegaal ACO, Martens JWM, Le Dévédec SE, van de Water B. Koedoot E, et al. J Exp Clin Cancer Res. 2021 Mar 1;40(1):82. doi: 10.1186/s13046-021-01863-4. J Exp Clin Cancer Res. 2021. PMID: 33648524 Free PMC article.
RESULTS: We identified nine splicing factors, including SNRPD2, SNRPD3 and NHP2L1, of which depletion inhibited proliferation in two TNBC cell lines by deregulation of sister chromatid cohesion (SCC) via increased sororin intron 1 retention and down-regulation of SMC1, MAU2 and …
RESULTS: We identified nine splicing factors, including SNRPD2, SNRPD3 and NHP2L1, of which depletion inhibited proliferation in two TNBC ce …
Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.
Brendle A, Brandt A, Johansson R, Enquist K, Hallmans G, Hemminki K, Lenner P, Försti A. Brendle A, et al. Eur J Cancer. 2009 Feb;45(3):435-42. doi: 10.1016/j.ejca.2008.10.001. Epub 2008 Nov 12. Eur J Cancer. 2009. PMID: 19008095
We investigated whether putatively functional single nucleotide polymorphisms (SNPs) in genes related to CIN (CENPF, ESPL1, NEK2, PTTG1, ZWILCH, ZWINT) affect breast cancer (BC) risk and clinical outcome in a Swedish cohort of 749 incident BC cases with detailed clinical d …
We investigated whether putatively functional single nucleotide polymorphisms (SNPs) in genes related to CIN (CENPF, ESPL1, NEK2, PTT …
ESPL1 is a candidate oncogene of luminal B breast cancers.
Finetti P, Guille A, Adelaide J, Birnbaum D, Chaffanet M, Bertucci F. Finetti P, et al. Breast Cancer Res Treat. 2014 Aug;147(1):51-9. doi: 10.1007/s10549-014-3070-z. Epub 2014 Aug 3. Breast Cancer Res Treat. 2014. PMID: 25086634
ESPL1/separase is a putative oncogene of luminal B breast cancers. ...Inhibiting ESPL1 may represent a promising therapeutic approach for these poor-prognosis tumors....
ESPL1/separase is a putative oncogene of luminal B breast cancers. ...Inhibiting ESPL1 may represent a promising therapeutic a
Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression.
Wu F, Zhang Y, Chen X, Wang Y, Peng H, Zhang Z, Yang Y, Wang Q. Wu F, et al. Environ Sci Pollut Res Int. 2022 Feb;29(8):11883-11892. doi: 10.1007/s11356-021-16542-2. Epub 2021 Sep 23. Environ Sci Pollut Res Int. 2022. PMID: 34558042
And the result of protein-protein interaction (PPI) analysis showed that the hub genes in these 246 DEGs were tumor protein p53 (TP53), polo-like kinase 1 (PLK1), sirtuin 1 (SIRT1), protein tyrosine phosphatase non-receptor type 11 (PTPN11), caspase 8 (CASP8), cyclin-dependent ki …
And the result of protein-protein interaction (PPI) analysis showed that the hub genes in these 246 DEGs were tumor protein p53 (TP53), polo …
BRCA1 regulates gene expression for orderly mitotic progression.
Bae I, Rih JK, Kim HJ, Kang HJ, Haddad B, Kirilyuk A, Fan S, Avantaggiati ML, Rosen EM. Bae I, et al. Cell Cycle. 2005 Nov;4(11):1641-66. doi: 10.4161/cc.4.11.2152. Epub 2005 Nov 7. Cell Cycle. 2005. PMID: 16258266
DNA microarray and confirmatory RNA analyses revealed that BRCA1 small interfering (si) RNA caused down-regulation of multiple genes implicated in the mitotic spindle checkpoint (eg., BUB1B, HEC, and STK6), chromosome segregation (eg., ESPL1, NEK2, and PTTG1), centrosome f …
DNA microarray and confirmatory RNA analyses revealed that BRCA1 small interfering (si) RNA caused down-regulation of multiple genes implica …