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Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Haaß W, Kleiner H, Weiß C, Haferlach C, Schlegelberger B, Müller MC, Hehlmann R, Hofmann WK, Fabarius A, Seifarth W; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung; German CML Study Group. Haaß W, et al. PLoS One. 2015 Jun 18;10(6):e0129648. doi: 10.1371/journal.pone.0129648. eCollection 2015. PLoS One. 2015. PMID: 26087013 Free PMC article.
We found a preferential acquisition of unbalanced ACA in patients with b3a2 vs. b2a2 fusion type (ratio: 6.3 vs. 1.6, p = 0.0246) concurring with a faster progress to blast crisis for b3a2 patients (p = 0.0124). ESPL1/Separase, a cysteine endopeptidase, is a key player in …
We found a preferential acquisition of unbalanced ACA in patients with b3a2 vs. b2a2 fusion type (ratio: 6.3 vs. 1.6, p = 0.0246) concurring …
Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia.
Šmahelová J, Kaštánková I, Poláková KM, Klamová H, Zemanová K, Tachezy R, Hamšíková E, Šmahel M. Šmahelová J, et al. Oncol Rep. 2017 Jan;37(1):547-554. doi: 10.3892/or.2016.5226. Epub 2016 Nov 7. Oncol Rep. 2017. PMID: 27840977
In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patient …
In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and …
Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.
Haaß W, Kleiner H, Müller MC, Hofmann WK, Fabarius A, Seifarth W. Haaß W, et al. PLoS One. 2015 Aug 12;10(8):e0133769. doi: 10.1371/journal.pone.0133769. eCollection 2015. PLoS One. 2015. PMID: 26267133 Free PMC article.
ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. ...
ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. …