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1990 1
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2000 3
2001 1
2003 4
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2006 1
2007 2
2008 3
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Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells.
Okamura K, Yamashita S, Ando H, Horibata Y, Aoyama C, Takagishi K, Izumi T, Vance DE, Sugimoto H. Okamura K, et al. Biochim Biophys Acta. 2009 Mar;1791(3):173-82. doi: 10.1016/j.bbalip.2008.12.016. Epub 2009 Jan 10. Biochim Biophys Acta. 2009. PMID: 19168148
When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2. These results suggest tha …
When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage- …
Bcl-XL expression correlates with primary macrophage differentiation, activation of functional competence, and survival and results from synergistic transcriptional activation by Ets2 and PU.1.
Sevilla L, Zaldumbide A, Carlotti F, Dayem MA, Pognonec P, Boulukos KE. Sevilla L, et al. J Biol Chem. 2001 May 25;276(21):17800-7. doi: 10.1074/jbc.M008270200. Epub 2001 Feb 15. J Biol Chem. 2001. PMID: 11278399 Free article.
We show that cell death is accompanied by decreases in the expression of anti-apoptotic Bcl-x(L) protein and the Ets2 and PU.1 proteins of the Ets transcription factor family. Macrophages require both priming and triggering signals independent of CSF-1 to kill neopl …
We show that cell death is accompanied by decreases in the expression of anti-apoptotic Bcl-x(L) protein and the Ets2 and PU.1 protei …
Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages.
Ma X, Jiang Z, Li N, Jiang W, Gao P, Yang M, Yu X, Wang G, Zhang Y. Ma X, et al. Aging (Albany NY). 2019 Nov 27;11(22):10610-10625. doi: 10.18632/aging.102480. Epub 2019 Nov 27. Aging (Albany NY). 2019. PMID: 31785145 Free PMC article.
Proper activation of Toll-like receptor (TLR)-mediated signaling and production of proinflammatory cytokines are critical for the initiation of innate immunity, while the specific mechanism maintaining inflammatory homeostasis remains mostly unknown. Here, we show that Ets2 …
Proper activation of Toll-like receptor (TLR)-mediated signaling and production of proinflammatory cytokines are critical for the initiation …
Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC. Pitarresi JR, et al. Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006. Neoplasia. 2016. PMID: 27659014 Free PMC article.
Surprisingly, fibroblast Ets-2 deletion significantly altered immune cell infiltration into the stroma, with an increased CD8+ T-cell population, and decreased presence of regulatory T cells (Tregs), myeloid-derived suppressor cells, and mature macrophages. The mechanism i …
Surprisingly, fibroblast Ets-2 deletion significantly altered immune cell infiltration into the stroma, with an increased CD8+ T-cell popula …
Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2.
Yang BS, Hauser CA, Henkel G, Colman MS, Van Beveren C, Stacey KJ, Hume DA, Maki RA, Ostrowski MC. Yang BS, et al. Mol Cell Biol. 1996 Feb;16(2):538-47. doi: 10.1128/MCB.16.2.538. Mol Cell Biol. 1996. PMID: 8552081 Free PMC article.
In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated 30-fold in NIH 3T3 fibroblasts and 80-fold in the macrophage-like line RAW264 by the combination of Ets1 or Ets2 and Ras but not by several other Ets fac …
In transient transfection assay, reporters containing RREs composed of Ets-AP-1 binding sites could be activated 30-fold in NIH 3T3 fibrobla …
Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators.
Boulukos KE, Pognonec P, Sariban E, Bailly M, Lagrou C, Ghysdael J. Boulukos KE, et al. Genes Dev. 1990 Mar;4(3):401-9. doi: 10.1101/gad.4.3.401. Genes Dev. 1990. PMID: 2186967 Free article.
The rapid induction of Ets2 after treatment of chicken bone marrow-derived macrophages by cMGF is blunted after down-regulation or inactivation of PKC, suggesting a role of PKC in the cMGF-induced signal transduction pathway. Because Ets2 is localized in the …
The rapid induction of Ets2 after treatment of chicken bone marrow-derived macrophages by cMGF is blunted after down-regulatio …
Machine Learning Reveals Ets2 as a Novel Target for Membranous Nephropathy Treatment and Its Role in Immune Infiltration.
Wan PZ, Xu TH, Tian BY, Guo GY, Li XL, Yao L. Wan PZ, et al. Front Med (Lausanne). 2022 Mar 18;9:813329. doi: 10.3389/fmed.2022.813329. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35372448 Free PMC article.
In addition, ETS2 was positively related to monocytes, M1 phase macrophages, and neutrophils and negatively correlated to plasma cells, CD4+ T memory cells, M2 macrophages, CD8+ T cells, memory B cells, and resting mast cells. CONCLUSION: (1) Machine learning …
In addition, ETS2 was positively related to monocytes, M1 phase macrophages, and neutrophils and negatively correlated to plas …
Ets-2 Propagates IL-6 Trans-Signaling Mediated Osteoclast-Like Changes in Human Rheumatoid Arthritis Synovial Fibroblast.
Singh AK, Haque M, Madarampalli B, Shi Y, Wildman BJ, Basit A, Khuder SA, Prasad B, Hassan Q, Ouseph MM, Ahmed S. Singh AK, et al. Front Immunol. 2021 Nov 2;12:746503. doi: 10.3389/fimmu.2021.746503. eCollection 2021. Front Immunol. 2021. PMID: 34795667 Free PMC article.
Chromatin immunoprecipitation (ChIP) analysis of CTSB and CTSK promoters showed direct Ets2 binding and transcriptional activation upon IL-6/IL-6R stimulation. Knockdown of Ets2 significantly inhibited IL-6/IL-6R-induced RANKL, CTSB, and CTSK expression and TRAP sta …
Chromatin immunoprecipitation (ChIP) analysis of CTSB and CTSK promoters showed direct Ets2 binding and transcriptional activation up …
Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
Zhao J, Huang K, Peng HZ, Feng JF. Zhao J, et al. Biochem Biophys Res Commun. 2020 Feb 19;522(4):960-964. doi: 10.1016/j.bbrc.2019.11.123. Epub 2019 Dec 3. Biochem Biophys Res Commun. 2020. PMID: 31810605
Thus, its precise regulatory mechanisms need to be fully addressed. Here we found that knockdown of protein C-ets-2 (Ets2) resulted in higher IL-6 production after TLRs activation in macrophages. ...Subsequentially, it enhanced histone deacetylation and inhibited Il …
Thus, its precise regulatory mechanisms need to be fully addressed. Here we found that knockdown of protein C-ets-2 (Ets2) resulted i …
Ets2-dependent stromal regulation of mouse mammary tumors.
Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG. Man AK, et al. Mol Cell Biol. 2003 Dec;23(23):8614-25. doi: 10.1128/MCB.23.23.8614-8625.2003. Mol Cell Biol. 2003. PMID: 14612405 Free PMC article.
Ets2(A72/A72) mice are viable and develop normally. However, combining the Ets2A72 allele with a deletion mutant of Ets2 results in lethality at E11.5 and shows that Ets2A72 is a hypomorphic allele. ...Decreased MMP-3 and MMP-9 mRNAs were confirmed in Ets2(A7 …
Ets2(A72/A72) mice are viable and develop normally. However, combining the Ets2A72 allele with a deletion mutant of Ets2 resul …
58 results