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Page 1
A disease-associated gene desert directs macrophage inflammation through ETS2.
Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, Papa I, Silva Dos Santos M, Zhang Q, Cameron AJ, Legrini A, Zhang T, Wood CS, New FN, Randzavola LO, Speidel L, Brown AC, Hall A, Saffioti F, Parkes EC, Edwards W, Direskeneli H, Grayson PC, Jiang L, Merkel PA, Saruhan-Direskeneli G, Sawalha AH, Tombetti E, Quaglia A, Thorburn D, Knight JC, Rochford AP, Murray CD, Divakar P, Green M, Nye E, MacRae JI, Jamieson NB, Skoglund P, Cader MZ, Wallace C, Thomas DC, Lee JC. Stankey CT, et al. Nature. 2024 Jun;630(8016):447-456. doi: 10.1038/s41586-024-07501-1. Epub 2024 Jun 5. Nature. 2024. PMID: 38839969 Free PMC article.
By investigating an intergenic haplotype on chr21q22-which has been independently linked to inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu's arteritis(3-6)-we identify that the causal gene, ETS2, is a central regulator of hu …
By investigating an intergenic haplotype on chr21q22-which has been independently linked to inflammatory bowel disease, ankylosing spondylit …
Bcl-XL expression correlates with primary macrophage differentiation, activation of functional competence, and survival and results from synergistic transcriptional activation by Ets2 and PU.1.
Sevilla L, Zaldumbide A, Carlotti F, Dayem MA, Pognonec P, Boulukos KE. Sevilla L, et al. J Biol Chem. 2001 May 25;276(21):17800-7. doi: 10.1074/jbc.M008270200. Epub 2001 Feb 15. J Biol Chem. 2001. PMID: 11278399 Free article.
We show that cell death is accompanied by decreases in the expression of anti-apoptotic Bcl-x(L) protein and the Ets2 and PU.1 proteins of the Ets transcription factor family. Macrophages require both priming and triggering signals independent of CSF-1 to kill neopl …
We show that cell death is accompanied by decreases in the expression of anti-apoptotic Bcl-x(L) protein and the Ets2 and PU.1 protei …
Identification of nuclear localization and nuclear export signals in Ets2, and the transcriptional regulation of Ets2 and CTP:phosphocholine cytidylyltransferase alpha in tetradecanoyl-13-acetate or macrophage-colony stimulating factor stimulated RAW264 cells.
Okamura K, Yamashita S, Ando H, Horibata Y, Aoyama C, Takagishi K, Izumi T, Vance DE, Sugimoto H. Okamura K, et al. Biochim Biophys Acta. 2009 Mar;1791(3):173-82. doi: 10.1016/j.bbalip.2008.12.016. Epub 2009 Jan 10. Biochim Biophys Acta. 2009. PMID: 19168148
When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage-colony stimulating factor, the transcription of CTalpha was enhanced accompanied by increased mRNA of Ets2. These results suggest tha …
When RAW264 cells, murine macrophage cell-line, were stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) or macrophage- …
The Role of ETS2 in Macrophage Inflammation.
Stankey CT, Lee JC. Stankey CT, et al. DNA Cell Biol. 2025 Apr 14. doi: 10.1089/dna.2025.0064. Online ahead of print. DNA Cell Biol. 2025. PMID: 40227609 Review.
With the move toward combination treatment-to maximize efficacy-targeting ETS2 presents a unique opportunity to potentially induce a broad therapeutic effect. However, there will be multiple challenges to overcome since direct ETS2 inhibition is unlikely to be feasi …
With the move toward combination treatment-to maximize efficacy-targeting ETS2 presents a unique opportunity to potentially induce a …
Ets2 suppresses inflammatory cytokines through MAPK/NF-kappaB signaling and directly binds to the IL-6 promoter in macrophages.
Ma X, Jiang Z, Li N, Jiang W, Gao P, Yang M, Yu X, Wang G, Zhang Y. Ma X, et al. Aging (Albany NY). 2019 Nov 27;11(22):10610-10625. doi: 10.18632/aging.102480. Epub 2019 Nov 27. Aging (Albany NY). 2019. PMID: 31785145 Free PMC article.
Proper activation of Toll-like receptor (TLR)-mediated signaling and production of proinflammatory cytokines are critical for the initiation of innate immunity, while the specific mechanism maintaining inflammatory homeostasis remains mostly unknown. Here, we show that Ets2 …
Proper activation of Toll-like receptor (TLR)-mediated signaling and production of proinflammatory cytokines are critical for the initiation …
The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, and Susceptibility to Inflammatory Bowel Disease.
Hume DA, Summers KM, O'Brien C, Pavli P. Hume DA, et al. Cell Mol Gastroenterol Hepatol. 2025 Mar 26:101510. doi: 10.1016/j.jcmgh.2025.101510. Online ahead of print. Cell Mol Gastroenterol Hepatol. 2025. PMID: 40154882 Free article. Review.
ETS2 is also both a downstream target and a mediator of the CSF1/CSF1R signaling pathway. Therapeutic targeting of ETS2 and its upstream regulators has the potential to prevent CSF1-dependent monocyte differentiation toward a prorepair resident macrophage phe …
ETS2 is also both a downstream target and a mediator of the CSF1/CSF1R signaling pathway. Therapeutic targeting of ETS2 and it …
ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation.
He L, Cai Q, Liang X, Xin J, Shi D, Ren K, Li Y, Chen J, Sun S, Guo B, Yang H, Li B, Ma S, Luo J, Hu M, Li J, Hu W, Li P, Yao H, Li J, Chen X, Jiang J, Li J. He L, et al. J Med Virol. 2023 Apr;95(4):e28710. doi: 10.1002/jmv.28710. J Med Virol. 2023. PMID: 36975761
The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify the molecular basis of ETS2 in ACLF pathogenesis. ...Knockout of ETS2 in macrophages confirmed the downregulation of IL-6 and IL-1beta caused by both HM …
The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify the molecular basis of ETS2 …
Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC. Pitarresi JR, et al. Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006. Neoplasia. 2016. PMID: 27659014 Free PMC article.
Surprisingly, fibroblast Ets-2 deletion significantly altered immune cell infiltration into the stroma, with an increased CD8+ T-cell population, and decreased presence of regulatory T cells (Tregs), myeloid-derived suppressor cells, and mature macrophages. The mechanism i …
Surprisingly, fibroblast Ets-2 deletion significantly altered immune cell infiltration into the stroma, with an increased CD8+ T-cell popula …
Machine Learning Reveals Ets2 as a Novel Target for Membranous Nephropathy Treatment and Its Role in Immune Infiltration.
Wan PZ, Xu TH, Tian BY, Guo GY, Li XL, Yao L. Wan PZ, et al. Front Med (Lausanne). 2022 Mar 18;9:813329. doi: 10.3389/fmed.2022.813329. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35372448 Free PMC article.
In addition, ETS2 was positively related to monocytes, M1 phase macrophages, and neutrophils and negatively correlated to plasma cells, CD4+ T memory cells, M2 macrophages, CD8+ T cells, memory B cells, and resting mast cells. CONCLUSION: (1) Machine learning …
In addition, ETS2 was positively related to monocytes, M1 phase macrophages, and neutrophils and negatively correlated to plas …
64 results