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26 results

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Page 1
Identification of candidate genes for endometrial cancer in multi-omics: a Mendelian randomization analysis.
Qin LH, Yang C, Song R, Chen PY, Jiang Z, Xu W, Zeng G, Liao JY, Long L. Qin LH, et al. Syst Biol Reprod Med. 2024 Dec;70(1):299-311. doi: 10.1080/19396368.2024.2411458. Epub 2024 Oct 14. Syst Biol Reprod Med. 2024. PMID: 39401154 Free article.
Our study showed that three genes, SNX11, LINC00243, and EVI2A, were identified as causally related to endometrial cancer. SNX11 exhibited a positive causal relationship, while LINC00243 and EVI2A showed negative ones. ...Colocalization analysis confirmed sig …
Our study showed that three genes, SNX11, LINC00243, and EVI2A, were identified as causally related to endometrial cancer. SNX …
Microenvironment-related prognostic genes in esophageal cancer.
Zhou MH, Wang XK. Zhou MH, et al. Transl Cancer Res. 2020 Dec;9(12):7531-7539. doi: 10.21037/tcr-20-2288. Transl Cancer Res. 2020. PMID: 35117353 Free PMC article.
BACKGROUND: Esophageal cancer is one of the most common malignant tumors. The role of tumor microenvironment in esophageal cancer is unclear. METHODS: The gene expression profiles and clinical data of 158 patients with esophageal cancer were extracted from Th …
BACKGROUND: Esophageal cancer is one of the most common malignant tumors. The role of tumor microenvironment in esophageal cancer …
Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma.
Liu R, Li S, Xiong S, Zheng F, Zhan X, Zeng J, Fu B, Xu S, Zhu S, Chen RU. Liu R, et al. Oncol Res. 2024 Oct 16;32(11):1733-1746. doi: 10.32604/or.2024.050851. eCollection 2024. Oncol Res. 2024. PMID: 39449801 Free PMC article.
We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. ...Elevated EVI2A expression suggests increased sensitivity to …
We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical …
Increased expression of ecotropic viral integration site 2A indicates a poor prognosis and promotes osteosarcoma evolution through activating MEK/ERK pathway.
Li S, Yang F, Yang YK, Zhou Y. Li S, et al. J Recept Signal Transduct Res. 2019 Aug;39(4):368-372. doi: 10.1080/10799893.2019.1669182. Epub 2019 Nov 27. J Recept Signal Transduct Res. 2019. PMID: 31774019
Although ecotropic viral integration site 2 A (EVI2A) plays key roles in several cancers, the expression and function of EVI2A in osteosarcoma (OS) have not been investigated. Hence, we explored the expression of EVI2A and its clinical significance of …
Although ecotropic viral integration site 2 A (EVI2A) plays key roles in several cancers, the expression and function of EV …
SMYD2 Imparts Gemcitabine Resistance to Pancreatic Adenocarcinoma Cells by Upregulating EVI2A.
Jin L, Qian D, Tang X, Huang Y, Zou J, Wu Z. Jin L, et al. Mol Biotechnol. 2024 Oct;66(10):2920-2933. doi: 10.1007/s12033-023-00908-7. Epub 2023 Oct 9. Mol Biotechnol. 2024. PMID: 37812330
EVI2A was found expressed highly in GEM-resistant PAAD cells. Gain-of-function analyses revealed that EVI2A encouraged the proliferation and motility of GEM-resistant cells and prevented apoptosis. In addition, EVI2A reduced T cell effector activation. SMYD2 …
EVI2A was found expressed highly in GEM-resistant PAAD cells. Gain-of-function analyses revealed that EVI2A encouraged the pro …
Exploring potential causal genetic variants and genes for endometrial cancer: Open Targets Genetics, Mendelian randomization, and multi-tissue transcriptome-wide association analysis.
Zhang G, Mao S, Yuan G, Wang Y, Yang J, Dai Y. Zhang G, et al. Transl Cancer Res. 2024 Nov 30;13(11):5971-5982. doi: 10.21037/tcr-24-887. Epub 2024 Nov 21. Transl Cancer Res. 2024. PMID: 39697733 Free PMC article.
BACKGROUND: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with incidence rates continuing to rise globally. ...CONCLUSIONS: We confirmed the involvement of EVI2A in the pathogenesis of EC and identified several other gen …
BACKGROUND: Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with incidence rates continui …
The NF1 translocation breakpoint region.
O'Connell P, Cawthon RM, Viskochil D, White R, Carey JC, Buchberg AM. O'Connell P, et al. Ann N Y Acad Sci. 1991;615:319-31. doi: 10.1111/j.1749-6632.1991.tb37774.x. Ann N Y Acad Sci. 1991. PMID: 1903909 Review.
Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer.
Poage GM, Houseman EA, Christensen BC, Butler RA, Avissar-Whiting M, McClean MD, Waterboer T, Pawlita M, Marsit CJ, Kelsey KT. Poage GM, et al. Clin Cancer Res. 2011 Jun 1;17(11):3579-89. doi: 10.1158/1078-0432.CCR-11-0044. Epub 2011 Apr 19. Clin Cancer Res. 2011. PMID: 21505061 Free PMC article.
PURPOSE: The human epigenome is profoundly altered in cancers, with a characteristic loss of methylation in repetitive regions and concomitant accumulation of gene promoter methylation. ...We validated the top CpG loci that had significant hypermethylation associated with …
PURPOSE: The human epigenome is profoundly altered in cancers, with a characteristic loss of methylation in repetitive regions and co …
NF1 microdeletion syndrome: case report of two new patients.
Serra G, Antona V, Corsello G, Zara F, Piro E, Falsaperla R. Serra G, et al. Ital J Pediatr. 2019 Nov 8;45(1):138. doi: 10.1186/s13052-019-0718-7. Ital J Pediatr. 2019. PMID: 31703719 Free PMC article.
Array comparative genomic hybridization (a-CGH) analysis defined a 17q11.2 deletion of about 1 Mb (breakpoints at positions 29,124,299 and 30,151,654), which involved different genes (partially CRLF3, ATAD5, TEFM, ADAP2, RNF135, OMG, EVI2B, EVI2A, RAB11FIP4), including NF1 …
Array comparative genomic hybridization (a-CGH) analysis defined a 17q11.2 deletion of about 1 Mb (breakpoints at positions 29,124,299 and 3 …
Single strand conformation analysis of two genes contained within the first intron of the neurofibromatosis type I gene in patients with multiple sclerosis.
Hinks LJ, Price SE, Mason CR, Thompson RJ. Hinks LJ, et al. Neuropathol Appl Neurobiol. 1995 Jun;21(3):201-7. doi: 10.1111/j.1365-2990.1995.tb01051.x. Neuropathol Appl Neurobiol. 1995. PMID: 7477728
This occurred in identical proportions (16.6%) in MS patients and controls. Two rare mutations were found in the EVI2A gene, one resulting in an arginine substituting for a glutamine (one control and one patient), the other in the replacement of a glycine with serine (one …
This occurred in identical proportions (16.6%) in MS patients and controls. Two rare mutations were found in the EVI2A gene, one resu …
26 results