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4,292 results

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Page 1
Early-Onset Alzheimer's Disease: What Is Missing in Research?
Ayodele T, Rogaeva E, Kurup JT, Beecham G, Reitz C. Ayodele T, et al. Curr Neurol Neurosci Rep. 2021 Jan 19;21(2):4. doi: 10.1007/s11910-020-01090-y. Curr Neurol Neurosci Rep. 2021. PMID: 33464407 Free PMC article. Review.
PURPOSE OF REVIEW: Early-onset Alzheimer's disease (EOAD), defined as Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the late-onset form (LOAD) despite EOAD often presenting with a …
PURPOSE OF REVIEW: Early-onset Alzheimer's disease (EOAD), defined as Alzheimer's diseas …
Early-onset familial Alzheimer's disease (EOFAD).
Wu L, Rosa-Neto P, Hsiung GY, Sadovnick AD, Masellis M, Black SE, Jia J, Gauthier S. Wu L, et al. Can J Neurol Sci. 2012 Jul;39(4):436-45. doi: 10.1017/s0317167100013949. Can J Neurol Sci. 2012. PMID: 22728850 Review.
Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset dementia (age at onset < 65 years) and a positive family history for dementia. ...The mutations within these three genes (PS1/PS2/APP) …
Early-onset familial Alzheimer's disease (EOFAD) is a condition characterized by early onset …
Molecular genetics of early-onset Alzheimer's disease revisited.
Cacace R, Sleegers K, Van Broeckhoven C. Cacace R, et al. Alzheimers Dement. 2016 Jun;12(6):733-48. doi: 10.1016/j.jalz.2016.01.012. Epub 2016 Mar 24. Alzheimers Dement. 2016. PMID: 27016693 Free article. Review.
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD came more or less to a standstill. ...Here, we aimed at summarizing the cur …
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant e …
Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease.
Kwapong WR, Tang F, Liu P, Zhang Z, Cao L, Feng Z, Yang S, Shu Y, Xu H, Lu Y, Zhao X, Chong B, Wu B, Liu M, Lei P, Zhang S. Kwapong WR, et al. Alzheimers Dement. 2024 Jun;20(6):4185-4198. doi: 10.1002/alz.13871. Epub 2024 May 15. Alzheimers Dement. 2024. PMID: 38747519 Free PMC article.
INTRODUCTION: This study addresses the urgent need for non-invasive early-onset Alzheimer's disease (EOAD) prediction. Using optical coherence tomography angiography (OCTA), we present a choriocapillaris model sensitive to EOAD, correlating with …
INTRODUCTION: This study addresses the urgent need for non-invasive early-onset Alzheimer's disease (EOAD …
Risk factors for Alzheimer's disease.
A Armstrong R. A Armstrong R. Folia Neuropathol. 2019;57(2):87-105. doi: 10.5114/fn.2019.85929. Folia Neuropathol. 2019. PMID: 31556570 Free article. Review.
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and associated co-morbidities such as vascular disease and infection. In th …
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inherita …
Learning slopes in early-onset Alzheimer's disease.
Hammers DB, Nemes S, Diedrich T, Eloyan A, Kirby K, Aisen P, Kramer J, Nudelman K, Foroud T, Rumbaugh M, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Weintraub S, Wingo TS, Wolk DA, Wong B, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; LEADS Consortium. Hammers DB, et al. Alzheimers Dement. 2023 Nov;19 Suppl 9(Suppl 9):S19-S28. doi: 10.1002/alz.13159. Epub 2023 May 27. Alzheimers Dement. 2023. PMID: 37243937 Free PMC article.
OBJECTIVE: Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight the sensitivity of learning slopes to discriminate disease severity in cognitively normal participants and those diagnosed with earl …
OBJECTIVE: Investigation of learning slopes in early-onset dementias has been limited. The current study aimed to highlight th …
Animal models of Alzheimer's disease: Applications, evaluation, and perspectives.
Chen ZY, Zhang Y. Chen ZY, et al. Zool Res. 2022 Nov 18;43(6):1026-1040. doi: 10.24272/j.issn.2095-8137.2022.289. Zool Res. 2022. PMID: 36317468 Free PMC article. Review.
Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease. ...With the development of transg …
Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer's disease (AD) have been made …
Evolution of Detecting Early Onset of Alzheimer's Disease: From Neuroimaging to Optical Immunoassays.
Hsiao WW, Angela S, Le TN, Ku CC, Hu PS, Chiang WH. Hsiao WW, et al. J Alzheimers Dis. 2023;93(3):821-845. doi: 10.3233/JAD-221202. J Alzheimers Dis. 2023. PMID: 37125550 Review.
Alzheimer's disease (AD) is a pathological disorder defined by the symptoms of memory loss and deterioration of cognitive abilities over time. ...
Alzheimer's disease (AD) is a pathological disorder defined by the symptoms of memory loss and deterioration of cogniti …
Brain inflammation co-localizes highly with tau in mild cognitive impairment due to early-onset Alzheimer's disease.
Appleton J, Finn Q, Zanotti-Fregonara P, Yu M, Faridar A, Nakawah MO, Zarate C, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG, Masdeu JC, Pascual B. Appleton J, et al. Brain. 2025 Jan 7;148(1):119-132. doi: 10.1093/brain/awae234. Brain. 2025. PMID: 39013020 Free PMC article.
We applied 11C-ER176 to detect brain inflammation in mild cognitive impairment (MCI) caused by early-onset Alzheimer's disease. Furthermore, we sought to correlate the brain localization of inflammation, volume loss, elevated amyloid-beta (Abeta …
We applied 11C-ER176 to detect brain inflammation in mild cognitive impairment (MCI) caused by early-onset Alzheimer' …
Early-onset Alzheimer's disease: nonamnestic subtypes and type 2 AD.
Mendez MF. Mendez MF. Arch Med Res. 2012 Nov;43(8):677-85. doi: 10.1016/j.arcmed.2012.11.009. Epub 2012 Nov 21. Arch Med Res. 2012. PMID: 23178565 Free PMC article. Review.
Patients with Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, are usually elderly; however, 4-5% develop early-onset AD (EOAD) with onset before age 65. Most EOAD is sporadic, but about 5% of patients with EOAD have an a …
Patients with Alzheimer's disease (AD), the most prevalent neurodegenerative dementia, are usually elderly; however, 4- …
4,292 results