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Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response.
Earnhart CG, Buckles EL, Dumler JS, Marconi RT. Earnhart CG, et al. Infect Immun. 2005 Dec;73(12):7869-77. doi: 10.1128/IAI.73.12.7869-7877.2005. Infect Immun. 2005. PMID: 16299277 Free PMC article.
Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.
Earnhart CG, Buckles EL, Marconi RT. Earnhart CG, et al. Vaccine. 2007 Jan 5;25(3):466-80. doi: 10.1016/j.vaccine.2006.07.052. Epub 2006 Aug 8. Vaccine. 2007. PMID: 16996663
Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development.
Buckles EL, Earnhart CG, Marconi RT. Buckles EL, et al. Clin Vaccine Immunol. 2006 Oct;13(10):1162-5. doi: 10.1128/CVI.00099-06. Clin Vaccine Immunol. 2006. PMID: 17028218 Free PMC article.
Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens.
Earnhart CG, Marconi RT. Earnhart CG, et al. Vaccine. 2007 Apr 30;25(17):3419-27. doi: 10.1016/j.vaccine.2006.12.051. Epub 2007 Jan 17. Vaccine. 2007. PMID: 17239505 Free PMC article.
OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.
Earnhart CG, Marconi RT. Earnhart CG, et al. Clin Vaccine Immunol. 2007 May;14(5):628-34. doi: 10.1128/CVI.00409-06. Epub 2007 Mar 14. Clin Vaccine Immunol. 2007. PMID: 17360854 Free PMC article. Clinical Trial.
Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.
Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD, Marconi RT. Earnhart CG, et al. Mol Microbiol. 2010 Apr;76(2):393-408. doi: 10.1111/j.1365-2958.2010.07103.x. Epub 2010 Feb 28. Mol Microbiol. 2010. PMID: 20199597 Free PMC article.
Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate.
Earnhart CG, Rhodes DV, Marconi RT. Earnhart CG, et al. Clin Vaccine Immunol. 2011 Jun;18(6):901-6. doi: 10.1128/CVI.05004-11. Epub 2011 Apr 27. Clin Vaccine Immunol. 2011. PMID: 21525304 Free PMC article.
Genetic transformation of the relapsing fever spirochete Borrelia hermsii: stable integration and expression of green fluorescent protein from linear plasmid 200.
Fine LM, Earnhart CG, Marconi RT. Fine LM, et al. Among authors: earnhart cg. J Bacteriol. 2011 Jul;193(13):3241-5. doi: 10.1128/JB.05037-11. Epub 2011 May 6. J Bacteriol. 2011. PMID: 21551306 Free PMC article.
Antibodies to Borrelia burgdorferi OspA, OspC, OspF, and C6 antigens as markers for early and late infection in dogs.
Wagner B, Freer H, Rollins A, Garcia-Tapia D, Erb HN, Earnhart C, Marconi R, Meeus P. Wagner B, et al. Clin Vaccine Immunol. 2012 Apr;19(4):527-35. doi: 10.1128/CVI.05653-11. Epub 2012 Feb 15. Clin Vaccine Immunol. 2012. PMID: 22336289 Free PMC article.
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