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After TGN1412: recent developments in cytokine release assays.
Stebbings R, Eastwood D, Poole S, Thorpe R. Stebbings R, et al. Among authors: eastwood d. J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11. J Immunotoxicol. 2013. PMID: 22967038 Free PMC article.
Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.
Vessillier S, Eastwood D, Fox B, Sathish J, Sethu S, Dougall T, Thorpe SJ, Thorpe R, Stebbings R. Vessillier S, et al. Among authors: eastwood d. J Immunol Methods. 2015 Sep;424:43-52. doi: 10.1016/j.jim.2015.04.020. Epub 2015 May 7. J Immunol Methods. 2015. PMID: 25960173 Free PMC article.
Antibody C region influences TGN1412-like functional activity in vitro.
Ball C, Fox B, Hufton S, Sharp G, Poole S, Stebbings R, Eastwood D, Findlay L, Parren PW, Thorpe R, Bristow A, Thorpe SJ. Ball C, et al. Among authors: eastwood d. J Immunol. 2012 Dec 15;189(12):5831-40. doi: 10.4049/jimmunol.1201795. Epub 2012 Nov 12. J Immunol. 2012. PMID: 23150712
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S. Stebbings R, et al. Among authors: eastwood d. J Immunol. 2007 Sep 1;179(5):3325-31. doi: 10.4049/jimmunol.179.5.3325. J Immunol. 2007. PMID: 17709549
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