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Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance.
Hiddinga HJ, Sakagashira S, Ishigame M, Madde P, Sanke T, Nanjo K, Kudva YC, Lee JJ, van Deursen J, Eberhardt NL. Hiddinga HJ, et al. Among authors: eberhardt nl. J Diabetes Investig. 2012 Mar 28;3(2):138-47. doi: 10.1111/j.2040-1124.2011.00166.x. J Diabetes Investig. 2012. PMID: 24843557 Free PMC article.
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.
Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H. Shigihara N, et al. Among authors: eberhardt nl. J Clin Invest. 2014 Aug;124(8):3634-44. doi: 10.1172/JCI69866. Epub 2014 Jul 18. J Clin Invest. 2014. PMID: 25036706 Free PMC article.
116 results