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183 results
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Targeting key steps in metastatic tumour progression.
Eccles SA. Eccles SA. Curr Opin Genet Dev. 2005 Feb;15(1):77-86. doi: 10.1016/j.gde.2004.12.001. Curr Opin Genet Dev. 2005. PMID: 15661537 Review.
Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging.
Boult JK, Borri M, Jury A, Popov S, Box G, Perryman L, Eccles SA, Jones C, Robinson SP. Boult JK, et al. Among authors: eccles sa. NMR Biomed. 2016 Nov;29(11):1608-1617. doi: 10.1002/nbm.3594. Epub 2016 Sep 27. NMR Biomed. 2016. PMID: 27671990 Free PMC article.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Eccles SA, Massey A, Raynaud FI, Sharp SY, Box G, Valenti M, Patterson L, de Haven Brandon A, Gowan S, Boxall F, Aherne W, Rowlands M, Hayes A, Martins V, Urban F, Boxall K, Prodromou C, Pearl L, James K, Matthews TP, Cheung KM, Kalusa A, Jones K, McDonald E, Barril X, Brough PA, Cansfield JE, Dymock B, Drysdale MJ, Finch H, Howes R, Hubbard RE, Surgenor A, Webb P, Wood M, Wright L, Workman P. Eccles SA, et al. Cancer Res. 2008 Apr 15;68(8):2850-60. doi: 10.1158/0008-5472.CAN-07-5256. Cancer Res. 2008. PMID: 18413753
The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.
Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE. Berry T, et al. Among authors: eccles sa. Cancer Cell. 2012 Jul 10;22(1):117-30. doi: 10.1016/j.ccr.2012.06.001. Cancer Cell. 2012. PMID: 22789543 Free PMC article.
Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β.
Bielen A, Perryman L, Box GM, Valenti M, de Haven Brandon A, Martins V, Jury A, Popov S, Gowan S, Jeay S, Raynaud FI, Hofmann F, Hargrave D, Eccles SA, Jones C. Bielen A, et al. Among authors: eccles sa. Mol Cancer Ther. 2011 Aug;10(8):1407-18. doi: 10.1158/1535-7163.MCT-11-0205. Epub 2011 Jun 9. Mol Cancer Ther. 2011. PMID: 21659463 Free PMC article.
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation.
Vinci M, Gowan S, Boxall F, Patterson L, Zimmermann M, Court W, Lomas C, Mendiola M, Hardisson D, Eccles SA. Vinci M, et al. Among authors: eccles sa. BMC Biol. 2012 Mar 22;10:29. doi: 10.1186/1741-7007-10-29. BMC Biol. 2012. PMID: 22439642 Free PMC article.
Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.
Andrikopoulos P, Baba A, Matsuda T, Djamgoz MB, Yaqoob MM, Eccles SA. Andrikopoulos P, et al. Among authors: eccles sa. J Biol Chem. 2011 Nov 4;286(44):37919-31. doi: 10.1074/jbc.M111.251777. Epub 2011 Aug 26. J Biol Chem. 2011. PMID: 21873429 Free PMC article.
In vitro assays for endothelial cell functions related to angiogenesis: proliferation, motility, tubular differentiation, and proteolysis.
Eccles SA, Court W, Patterson L, Sanderson S. Eccles SA, et al. Methods Mol Biol. 2009;467:159-81. doi: 10.1007/978-1-59745-241-0_9. Methods Mol Biol. 2009. PMID: 19301670
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma.
Guillard S, Clarke PA, Te Poele R, Mohri Z, Bjerke L, Valenti M, Raynaud F, Eccles SA, Workman P. Guillard S, et al. Among authors: eccles sa. Cell Cycle. 2009 Feb 1;8(3):443-53. doi: 10.4161/cc.8.3.7643. Epub 2009 Feb 16. Cell Cycle. 2009. PMID: 19177002
PLCgamma1 is essential for early events in integrin signalling required for cell motility.
Jones NP, Peak J, Brader S, Eccles SA, Katan M. Jones NP, et al. Among authors: eccles sa. J Cell Sci. 2005 Jun 15;118(Pt 12):2695-706. doi: 10.1242/jcs.02374. J Cell Sci. 2005. PMID: 15944397
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