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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1992 1
1993 1
1994 2
1995 3
1996 4
1997 1
1998 3
1999 5
2000 3
2001 5
2002 2
2003 11
2004 8
2005 4
2006 2
2007 7
2008 4
2009 3
2010 6
2011 5
2012 6
2013 6
2014 6
2015 7
2016 7
2017 5
2018 2
2019 5
2020 4
2021 5
2022 5
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133 results
Results by year
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Page 1
An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.
To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. To C, et al. Among authors: eck mj. Nat Cancer. 2022 Apr;3(4):402-417. doi: 10.1038/s43018-022-00351-8. Epub 2022 Apr 14. Nat Cancer. 2022. PMID: 35422503 Free PMC article.
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.
Gero TW, Heppner DE, Beyett TS, To C, Azevedo SC, Jang J, Bunnell T, Feru F, Li Z, Shin BH, Soroko KM, Gokhale PC, Gray NS, Jänne PA, Eck MJ, Scott DA. Gero TW, et al. Among authors: eck mj. Bioorg Med Chem Lett. 2022 Jul 15;68:128718. doi: 10.1016/j.bmcl.2022.128718. Epub 2022 Apr 1. Bioorg Med Chem Lett. 2022. PMID: 35378251
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. Wittlinger F, et al. Among authors: eck mj. J Med Chem. 2022 Jan 27;65(2):1370-1383. doi: 10.1021/acs.jmedchem.1c00848. Epub 2021 Oct 20. J Med Chem. 2022. PMID: 34668706 Free PMC article.
The structural basis of PTEN regulation by multi-site phosphorylation.
Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. Dempsey DR, et al. Among authors: eck mj. Nat Struct Mol Biol. 2021 Oct;28(10):858-868. doi: 10.1038/s41594-021-00668-5. Epub 2021 Oct 8. Nat Struct Mol Biol. 2021. PMID: 34625746
133 results