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Piracetam: novelty in a unique mode of action.
Müller WE, Eckert GP, Eckert A. Müller WE, et al. Among authors: eckert gp, eckert a. Pharmacopsychiatry. 1999 Mar;32 Suppl 1:2-9. doi: 10.1055/s-2007-979230. Pharmacopsychiatry. 1999. PMID: 10338102 Review.
This novel mechanism of piracetam thus combines a rather non-specific physico-chemical mode of action with the pharmacological and clinical experience with this unique drug - effects are always much more pronounced when function is impaired....
This novel mechanism of piracetam thus combines a rather non-specific physico-chemical mode of action with the pharmacological and cl …
Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761.
Eckert A, Keil U, Scherping I, Hauptmann S, Müller WE. Eckert A, et al. Ann N Y Acad Sci. 2005 Nov;1056:474-85. doi: 10.1196/annals.1352.023. Ann N Y Acad Sci. 2005. PMID: 16387710
Taken together, our findings clearly show stabilization and protection of mitochondrial function as a specific and very sensitive property of EGb 761 at therapeutically relevant doses....
Taken together, our findings clearly show stabilization and protection of mitochondrial function as a specific and very sensitive pro …
The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide.
Kurz C, Ungerer I, Lipka U, Kirr S, Schütt T, Eckert A, Leuner K, Müller WE. Kurz C, et al. Among authors: eckert a. Br J Pharmacol. 2010 May;160(2):246-57. doi: 10.1111/j.1476-5381.2010.00656.x. Epub 2010 Mar 9. Br J Pharmacol. 2010. PMID: 20218980 Free PMC article.
BACKGROUND AND PURPOSE: beta-Amyloid peptide (Abeta) is implicated in the pathogenesis of Alzheimer's disease by initiating a cascade of events from mitochondrial dysfunction to neuronal death. ...
BACKGROUND AND PURPOSE: beta-Amyloid peptide (Abeta) is implicated in the pathogenesis of Alzheimer's disease by initiating a cascade …
Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice.
Hauptmann S, Scherping I, Dröse S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Müller WE. Hauptmann S, et al. Among authors: eckert a. Neurobiol Aging. 2009 Oct;30(10):1574-86. doi: 10.1016/j.neurobiolaging.2007.12.005. Epub 2008 Mar 4. Neurobiol Aging. 2009. PMID: 18295378
Recent evidence suggests mitochondrial dysfunction as a common early pathomechanism in Alzheimer's disease integrating genetic factors related to enhanced amyloid-beta (Ass) production and tau-hyperphosphorylation with aging, as the most relevant sporadic risk factor. ...P …
Recent evidence suggests mitochondrial dysfunction as a common early pathomechanism in Alzheimer's disease integrating genetic factor …
Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure.
Keil U, Bonert A, Marques CA, Strosznajder JB, Müller-Spahn F, Müller WE, Eckert A. Keil U, et al. Among authors: eckert a. Pol J Pharmacol. 2004 Sep-Oct;56(5):631-4. Pol J Pharmacol. 2004. PMID: 15591653
Mitochondrial dysfunction has been identified in a large proportion of neurodegenerative disorders including Alzheimer's disease (AD). ...On the basis of our data, we propose a hypothetical sequence of events linking amyloid beta-peptide and NO production with mitoc …
Mitochondrial dysfunction has been identified in a large proportion of neurodegenerative disorders including Alzheimer's disease (AD) …
Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress.
Eckert A, Keil U, Kressmann S, Schindowski K, Leutner S, Leutz S, Müller WE. Eckert A, et al. Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S15-23. doi: 10.1055/s-2003-40449. Pharmacopsychiatry. 2003. PMID: 13130384 Review.
Mitochondrial damage could play a pivotal role in the cell death decision. A decrease in mitochondrial energy charge and redox state, loss of transmembrane potential (depolarization), mitochondrial respiratory chain impairment, and release of substances such as calc …
Mitochondrial damage could play a pivotal role in the cell death decision. A decrease in mitochondrial energy charge and redox …
ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain.
Leutner S, Eckert A, Müller WE. Leutner S, et al. Among authors: eckert a. J Neural Transm (Vienna). 2001;108(8-9):955-67. doi: 10.1007/s007020170015. J Neural Transm (Vienna). 2001. PMID: 11716148
Nevertheless, there was a significant delay in the time course of ROS-generation in brain cells from old mice. The activities of the antioxidant enzymes CuZn-superoxide dismutase and glutathione reductase increased with age whereas glutathione peroxidase remained unchanged …
Nevertheless, there was a significant delay in the time course of ROS-generation in brain cells from old mice. The activities of the …
Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.
Leutner S, Czech C, Schindowski K, Touchet N, Eckert A, Müller WE. Leutner S, et al. Among authors: eckert a. Neurosci Lett. 2000 Oct 6;292(2):87-90. doi: 10.1016/s0304-3940(00)01449-x. Neurosci Lett. 2000. PMID: 10998555
Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. ...Mice with multiple PS1 mutations showed a significantly decreased activity …
Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibi …
Age-related changes of apoptotic cell death in human lymphocytes.
Schindowski K, Leutner S, Müller WE, Eckert A. Schindowski K, et al. Among authors: eckert a. Neurobiol Aging. 2000 Sep-Oct;21(5):661-70. doi: 10.1016/s0197-4580(00)00171-8. Neurobiol Aging. 2000. PMID: 11016535
We could show that PBL from elderly individuals (>60 years) accumulate apoptosing cells to a significant higher extent in spontaneous and activation-induced cell death compared to younger controls (<35 years). Treatment with the oxidative stressor 2-deoxy-D-ribose or …
We could show that PBL from elderly individuals (>60 years) accumulate apoptosing cells to a significant higher extent in spontane …
Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease.
Leuner K, Pantel J, Frey C, Schindowski K, Schulz K, Wegat T, Maurer K, Eckert A, Müller WE. Leuner K, et al. Among authors: eckert a. J Neural Transm Suppl. 2007;(72):207-15. doi: 10.1007/978-3-211-73574-9_27. J Neural Transm Suppl. 2007. PMID: 17982897 Review.
Until now, AD cannot be diagnosed by a valid clinical method or a biomarker before the disease has progressed so far that dementia is present. ...In this review, we discuss the potential role of elevated apoptosis, increased oxidative stress and mitochondrial dysfun …
Until now, AD cannot be diagnosed by a valid clinical method or a biomarker before the disease has progressed so far that deme …
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