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95 results
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Substrate-targeting gamma-secretase modulators.
Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.
An update on the amyloid hypothesis.
Eckman CB, Eckman EA. Eckman CB, et al. Among authors: eckman ea. Neurol Clin. 2007 Aug;25(3):669-82, vi. doi: 10.1016/j.ncl.2007.03.007. Neurol Clin. 2007. PMID: 17659184 Free PMC article. Review.
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. Among authors: eckman cb. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B. Brown J 3rd, et al. Among authors: eckman cb. J Biol Chem. 2004 Aug 13;279(33):34674-81. doi: 10.1074/jbc.M402324200. Epub 2004 May 17. J Biol Chem. 2004. PMID: 15148325
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