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SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.
Economou A, Wickner W. Economou A, et al. Cell. 1994 Sep 9;78(5):835-43. doi: 10.1016/s0092-8674(94)90582-7. Cell. 1994. PMID: 8087850
SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound …
SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state …
Substrate-activated conformational switch on chaperones encodes a targeting signal in type III secretion.
Chen L, Ai X, Portaliou AG, Minetti CA, Remeta DP, Economou A, Kalodimos CG. Chen L, et al. Among authors: economou a. Cell Rep. 2013 Mar 28;3(3):709-15. doi: 10.1016/j.celrep.2013.02.025. Epub 2013 Mar 21. Cell Rep. 2013. PMID: 23523349 Free PMC article.
A TTS peripheral membrane ATPase protein located at the base of the injectisome has been implicated in the targeting process. ...Structure analysis revealed that the targeting signal is encoded in a disorder-order structural transition in CesAB that is elicited only
A TTS peripheral membrane ATPase protein located at the base of the injectisome has been implicated in the targeting process. ...Stru
Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR.
Gelis I, Bonvin AM, Keramisanou D, Koukaki M, Gouridis G, Karamanou S, Economou A, Kalodimos CG. Gelis I, et al. Among authors: economou a. Cell. 2007 Nov 16;131(4):756-69. doi: 10.1016/j.cell.2007.09.039. Cell. 2007. PMID: 18022369 Free PMC article.
Here, we present the solution structure of a signal peptide bound to SecA, the 204 kDa ATPase motor of the Sec translocase. Upon encounter, the signal peptide forms an alpha-helix that inserts into a flexible and elongated groove in SecA. ...Finally, it is shown tha …
Here, we present the solution structure of a signal peptide bound to SecA, the 204 kDa ATPase motor of the Sec translocase. Upon enco …
Disorder-order folding transitions underlie catalysis in the helicase motor of SecA.
Keramisanou D, Biris N, Gelis I, Sianidis G, Karamanou S, Economou A, Kalodimos CG. Keramisanou D, et al. Among authors: economou a. Nat Struct Mol Biol. 2006 Jul;13(7):594-602. doi: 10.1038/nsmb1108. Epub 2006 Jun 18. Nat Struct Mol Biol. 2006. PMID: 16783375
NMR, thermodynamic and biochemical data show that SecA uses a novel mechanism wherein conserved regions lining the nucleotide cleft undergo cycles of disorder-order transitions while switching among functional catalytic states. ...The intrinsic plasticity and functional di …
NMR, thermodynamic and biochemical data show that SecA uses a novel mechanism wherein conserved regions lining the nucleotide cleft u …
Structure of dimeric SecA, the Escherichia coli preprotein translocase motor.
Papanikolau Y, Papadovasilaki M, Ravelli RB, McCarthy AA, Cusack S, Economou A, Petratos K. Papanikolau Y, et al. Among authors: economou a. J Mol Biol. 2007 Mar 9;366(5):1545-57. doi: 10.1016/j.jmb.2006.12.049. Epub 2006 Dec 23. J Mol Biol. 2007. PMID: 17229438
SecA is the preprotein translocase ATPase subunit and a superfamily 2 (SF2) RNA helicase. Here we present the 2 A crystal structures of the Escherichia coli SecA homodimer in the apo form and in complex with ATP, ADP and adenosine 5'-[beta,gamma-imido]triphosphate ( …
SecA is the preprotein translocase ATPase subunit and a superfamily 2 (SF2) RNA helicase. Here we present the 2 A crystal stru …
Quaternary dynamics of the SecA motor drive translocase catalysis.
Gouridis G, Karamanou S, Sardis MF, Schärer MA, Capitani G, Economou A. Gouridis G, et al. Among authors: economou a. Mol Cell. 2013 Dec 12;52(5):655-66. doi: 10.1016/j.molcel.2013.10.036. Mol Cell. 2013. PMID: 24332176
SecA docks on SecYEG as a dimer and becomes functionally asymmetric. Docking occurs via only one protomer. The second protomer allosterically regulates downstream steps. ...This is a unique example of one protein exploiting quaternary dynamics to become a sub …
SecA docks on SecYEG as a dimer and becomes functionally asymmetric. Docking occurs via only one protomer. The second protomer allost …
Preprotein Conformational Dynamics Drive Bivalent Translocase Docking and Secretion.
Sardis MF, Tsirigotaki A, Chatzi KE, Portaliou AG, Gouridis G, Karamanou S, Economou A. Sardis MF, et al. Among authors: economou a. Structure. 2017 Jul 5;25(7):1056-1067.e6. doi: 10.1016/j.str.2017.05.012. Epub 2017 Jun 15. Structure. 2017. PMID: 28625790
We now reveal that secretory preproteins use a dual-key mechanism to bridge the signal peptide and mature domain receptor sites and cooperatively enhance their affinities. ...
We now reveal that secretory preproteins use a dual-key mechanism to bridge the signal peptide and mature domain receptor sites and c …
Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.
De Waelheyns E, Segers K, Sardis MF, Anné J, Nicolaes GA, Economou A. De Waelheyns E, et al. Among authors: economou a. J Antibiot (Tokyo). 2015 Nov;68(11):666-73. doi: 10.1038/ja.2015.53. Epub 2015 May 20. J Antibiot (Tokyo). 2015. PMID: 25990955
SecA is a peripheral membrane ATPase and a key component of the Sec secretion pathway, the major route for bacterial protein export across or into the cytoplasmic membrane. ...A starting collection of ~500 000 commercially available small-molecules was virtua …
SecA is a peripheral membrane ATPase and a key component of the Sec secretion pathway, the major route for bacterial protein e …
SecA-mediated targeting and translocation of secretory proteins.
Chatzi KE, Sardis MF, Economou A, Karamanou S. Chatzi KE, et al. Among authors: economou a. Biochim Biophys Acta. 2014 Aug;1843(8):1466-74. doi: 10.1016/j.bbamcr.2014.02.014. Epub 2014 Feb 25. Biochim Biophys Acta. 2014. PMID: 24583121 Review.
More than 30 years of research have revealed that the dynamic nanomotor SecA is a central player in bacterial protein secretion. ...This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economo
More than 30 years of research have revealed that the dynamic nanomotor SecA is a central player in bacterial protein secretion. ...T …
SecA: a tale of two protomers.
Sardis MF, Economou A. Sardis MF, et al. Among authors: economou a. Mol Microbiol. 2010 Jun 1;76(5):1070-81. doi: 10.1111/j.1365-2958.2010.07176.x. Epub 2010 Apr 23. Mol Microbiol. 2010. PMID: 20444093 Review.
Bacteria, Archaea and Eukaryotes have evolved a plethora of mechanisms to translocate proteins across their various membranes. ...Unexpectedly, structures of SecA dimers from different or even the same bacterium do not have a consistent dimerization interface. ...
Bacteria, Archaea and Eukaryotes have evolved a plethora of mechanisms to translocate proteins across their various membranes. ...Une …
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