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Page 1
A Catalytically Inactive Protein Kinase C alpha Mutation Drives Chordoid Glioma by Pathway Rewiring.
Bellamy C, Tovell H, Schwaighofer S, Baffi TR, Arslan J, Letourneur Q, Dingli F, Loew D, Kornev A, Lerond J, Kao TH, Liva S, Izac B, Andrieu M, Adle-Biassette H, Barnier JV, Stefan E, Sanson M, Newton AC, Bielle F. Bellamy C, et al. Among authors: stefan e. bioRxiv [Preprint]. 2025 May 31:2025.05.30.657104. doi: 10.1101/2025.05.30.657104. bioRxiv. 2025. PMID: 40501730 Free PMC article. Preprint.
CDK6 kinase inhibition unmasks metabolic dependencies in BCR::ABL1+ leukemia.
Scheiblecker L, Klampfl T, Doma E, Nebenfuehr S, Torres-Quesada O, Strich S, Heller G, Werdenich D, Tschulenk W, Zojer M, Bellutti F, Schirripa A, Zöchbauer-Müller S, Valent P, Walter I, Stefan E, Sexl V, Kollmann K. Scheiblecker L, et al. Among authors: stefan e, torres quesada o. Cell Death Dis. 2025 Feb 18;16(1):107. doi: 10.1038/s41419-025-07434-1. Cell Death Dis. 2025. PMID: 39966356 Free PMC article.
Cdk6's functions are critically regulated by its unique C-terminus.
Schirripa A, Schöppe H, Nebenfuehr S, Zojer M, Klampfl T, Kugler V, Maw BS, Ceylan H, Uras IZ, Scheiblecker L, Gamper E, Stelzl U, Stefan E, Kaserer T, Sexl V, Kollmann K. Schirripa A, et al. Among authors: stefan e. iScience. 2024 Dec 27;28(2):111697. doi: 10.1016/j.isci.2024.111697. eCollection 2025 Feb 21. iScience. 2024. PMID: 39898030 Free PMC article.
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system.
Costacurta F, Dodaro A, Bante D, Schöppe H, Peng JY, Sprenger B, He X, Moghadasi SA, Egger LM, Fleischmann J, Pavan M, Bassani D, Menin S, Rauch S, Krismer L, Sauerwein A, Heberle A, Rabensteiner T, Ho J, Harris RS, Stefan E, Schneider R, Dunzendorfer-Matt T, Naschberger A, Wang D, Kaserer T, Moro S, von Laer D, Heilmann E. Costacurta F, et al. Among authors: stefan e. PLoS Pathog. 2024 Sep 11;20(9):e1012522. doi: 10.1371/journal.ppat.1012522. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39259728 Free PMC article.
Impact of protein and small molecule interactions on kinase conformations.
Kugler V, Schwaighofer S, Feichtner A, Enzler F, Fleischmann J, Strich S, Schwarz S, Wilson R, Tschaikner P, Troppmair J, Sexl V, Meier P, Kaserer T, Stefan E. Kugler V, et al. Among authors: stefan e. Elife. 2024 Aug 1;13:RP94755. doi: 10.7554/eLife.94755. Elife. 2024. PMID: 39088265 Free PMC article.
Author Correction: Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
Rinaldi L, Donne RD, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A. Rinaldi L, et al. Among authors: stefan e, torres quesada o. Nat Commun. 2024 May 29;15(1):4565. doi: 10.1038/s41467-024-49118-y. Nat Commun. 2024. PMID: 38811561 Free PMC article. No abstract available.
A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.
Benjamin-Zukerman T, Shimon G, Gaine ME, Dakwar A, Peled N, Aboraya M, Masri-Ismail A, Safadi-Safa R, Solomon M, Lev-Ram V, Rissman RA, Mayrhofer JE, Raffeiner A, Mol MO, Argue BMR, McCool S, Doan B, van Swieten J, Stefan E, Abel T, Ilouz R. Benjamin-Zukerman T, et al. Among authors: stefan e. Brain. 2024 Nov 4;147(11):3890-3905. doi: 10.1093/brain/awae154. Brain. 2024. PMID: 38743596 Free PMC article.
Complement C7 and clusterin form a complex in circulation.
Massri M, Toonen EJM, Sarg B, Kremser L, Grasse M, Fleischer V, Torres-Quesada O, Hengst L, Skjoedt MO, Bayarri-Olmos R, Rosbjerg A, Garred P, Orth-Höller D, Prohászka Z, Würzner R. Massri M, et al. Among authors: torres quesada o. Front Immunol. 2024 Jan 25;15:1330095. doi: 10.3389/fimmu.2024.1330095. eCollection 2024. Front Immunol. 2024. PMID: 38333209 Free PMC article.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: stefan e. Nat Struct Mol Biol. 2024 Apr;31(4):667-677. doi: 10.1038/s41594-024-01223-8. Epub 2024 Feb 7. Nat Struct Mol Biol. 2024. PMID: 38326651 Free PMC article.
A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system.
Costacurta F, Dodaro A, Bante D, Schöppe H, Sprenger B, Moghadasi SA, Fleischmann J, Pavan M, Bassani D, Menin S, Rauch S, Krismer L, Sauerwein A, Heberle A, Rabensteiner T, Ho J, Harris RS, Stefan E, Schneider R, Kaserer T, Moro S, von Laer D, Heilmann E. Costacurta F, et al. Among authors: stefan e. bioRxiv [Preprint]. 2023 Oct 4:2023.09.22.558628. doi: 10.1101/2023.09.22.558628. bioRxiv. 2023. Update in: PLoS Pathog. 2024 Sep 11;20(9):e1012522. doi: 10.1371/journal.ppat.1012522. PMID: 37808638 Free PMC article. Updated. Preprint.
Tracking and blocking interdependencies of cellular BRAF-MEK oncokinase activities.
Fleischmann J, Schwaighofer S, De Falco L, Enzler F, Feichtner A, Kugler V, Tschaikner P, Huber RG, Stefan E. Fleischmann J, et al. Among authors: stefan e. PNAS Nexus. 2023 Jun 5;2(6):pgad185. doi: 10.1093/pnasnexus/pgad185. eCollection 2023 Jun. PNAS Nexus. 2023. PMID: 37325027 Free PMC article.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: stefan e. bioRxiv [Preprint]. 2023 May 24:2023.05.23.540554. doi: 10.1101/2023.05.23.540554. bioRxiv. 2023. Update in: Nat Struct Mol Biol. 2024 Apr;31(4):667-677. doi: 10.1038/s41594-024-01223-8. PMID: 37292845 Free PMC article. Updated. Preprint.
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Delle Donne R, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-Quesada O, Stefan E, Kwiatkowski M, van Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A. Senatore E, et al. Among authors: stefan e, torres quesada o. EMBO J. 2021 May 17;40(10):e106503. doi: 10.15252/embj.2020106503. Epub 2021 May 2. EMBO J. 2021. PMID: 33934390 Free PMC article.
mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Among authors: stefan e. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: stefan e, torres quesada o. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.
Mayrhofer JE, Enzler F, Feichtner A, Röck R, Fleischmann J, Raffeiner A, Tschaikner P, Ogris E, Huber RG, Hartl M, Schneider R, Troppmair J, Torres-Quesada O, Stefan E. Mayrhofer JE, et al. Among authors: stefan e, torres quesada o. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31105-31113. doi: 10.1073/pnas.2012150117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229534 Free PMC article.
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.
Rinaldi L, Delle Donne R, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A. Rinaldi L, et al. Among authors: stefan e, torres quesada o. Nat Commun. 2019 Jun 12;10(1):2572. doi: 10.1038/s41467-019-10037-y. Nat Commun. 2019. PMID: 31189917 Free PMC article.
Counterregulation of cAMP-directed kinase activities controls ciliogenesis.
Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres-Quesada O, Intartaglia D, Garbi C, Insabato L, Santoriello M, Bachmann VA, Synofzik M, Lindner HH, Conte I, Stefan E, Feliciello A. Porpora M, et al. Among authors: stefan e, torres quesada o. Nat Commun. 2018 Mar 26;9(1):1224. doi: 10.1038/s41467-018-03643-9. Nat Commun. 2018. PMID: 29581457 Free PMC article.
The many faces of compartmentalized PKA signalosomes.
Torres-Quesada O, Mayrhofer JE, Stefan E. Torres-Quesada O, et al. Among authors: stefan e. Cell Signal. 2017 Sep;37:1-11. doi: 10.1016/j.cellsig.2017.05.012. Epub 2017 May 18. Cell Signal. 2017. PMID: 28528970 Free article. Review.
Calcium-dependent binding of Myc to calmodulin.
Raffeiner P, Schraffl A, Schwarz T, Röck R, Ledolter K, Hartl M, Konrat R, Stefan E, Bister K. Raffeiner P, et al. Among authors: stefan e. Oncotarget. 2017 Jan 10;8(2):3327-3343. doi: 10.18632/oncotarget.13759. Oncotarget. 2017. PMID: 27926480 Free PMC article.
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.
Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Bachmann VA, et al. Among authors: stefan e. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7786-91. doi: 10.1073/pnas.1608061113. Epub 2016 Jun 28. Proc Natl Acad Sci U S A. 2016. PMID: 27357676 Free PMC article.
Stopping MYC in its tracks.
Stefan E, Hart JR, Bister K. Stefan E, et al. Aging (Albany NY). 2015 Jul;7(7):463-4. doi: 10.18632/aging.100780. Aging (Albany NY). 2015. PMID: 26187009 Free PMC article. No abstract available.
Systematic identification of signal integration by protein kinase A.
Filteau M, Diss G, Torres-Quiroz F, Dubé AK, Schraffl A, Bachmann VA, Gagnon-Arsenault I, Chrétien AÈ, Steunou AL, Dionne U, Côté J, Bisson N, Stefan E, Landry CR. Filteau M, et al. Among authors: stefan e. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4501-6. doi: 10.1073/pnas.1409938112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831502 Free PMC article.
Inhibitor of MYC identified in a Kröhnke pyridine library.
Hart JR, Garner AL, Yu J, Ito Y, Sun M, Ueno L, Rhee JK, Baksh MM, Stefan E, Hartl M, Bister K, Vogt PK, Janda KD. Hart JR, et al. Among authors: stefan e. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61. doi: 10.1073/pnas.1319488111. Epub 2014 Aug 11. Proc Natl Acad Sci U S A. 2014. PMID: 25114221 Free PMC article.
Reciprocal regulation of PKA and Rac signaling.
Bachmann VA, Riml A, Huber RG, Baillie GS, Liedl KR, Valovka T, Stefan E. Bachmann VA, et al. Among authors: stefan e. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8531-6. doi: 10.1073/pnas.1215902110. Epub 2013 May 8. Proc Natl Acad Sci U S A. 2013. PMID: 23657011 Free PMC article.
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.
Lignitto L, Arcella A, Sepe M, Rinaldi L, Delle Donne R, Gallo A, Stefan E, Bachmann VA, Oliva MA, Tiziana Storlazzi C, L'Abbate A, Brunetti A, Gargiulo S, Gramanzini M, Insabato L, Garbi C, Gottesman ME, Feliciello A. Lignitto L, et al. Among authors: stefan e. Nat Commun. 2013;4:1822. doi: 10.1038/ncomms2791. Nat Commun. 2013. PMID: 23652010 Free PMC article.
A survey of sRNA families in α-proteobacteria.
del Val C, Romero-Zaliz R, Torres-Quesada O, Peregrina A, Toro N, Jiménez-Zurdo JI. del Val C, et al. Among authors: torres quesada o. RNA Biol. 2012 Feb;9(2):119-29. doi: 10.4161/rna.18643. Epub 2012 Feb 1. RNA Biol. 2012. PMID: 22418845 Free PMC article.
Control of PKA stability and signalling by the RING ligase praja2.
Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticò R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A. Lignitto L, et al. Among authors: stefan e. Nat Cell Biol. 2011 Apr;13(4):412-22. doi: 10.1038/ncb2209. Epub 2011 Mar 20. Nat Cell Biol. 2011. PMID: 21423175
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Skoumbourdis AP, Leclair CA, Stefan E, Turjanski AG, Maguire W, Titus SA, Huang R, Auld DS, Inglese J, Austin CP, Michnick SW, Xia M, Thomas CJ. Skoumbourdis AP, et al. Among authors: stefan e. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. doi: 10.1016/j.bmcl.2009.01.057. Epub 2009 Jan 23. Bioorg Med Chem Lett. 2009. PMID: 19464886 Free PMC article.
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky PI, Stefan E, Frische S, Santamaria K, Wiesner B, Valenti G, Hammer JA 3rd, Nielsen S, Goldenring JR, Rosenthal W, Klussmann E. Nedvetsky PI, et al. Among authors: stefan e. Traffic. 2007 Feb;8(2):110-23. doi: 10.1111/j.1600-0854.2006.00508.x. Epub 2006 Dec 6. Traffic. 2007. PMID: 17156409 Free article.
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky P, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E. Stefan E, et al. J Am Soc Nephrol. 2007 Jan;18(1):199-212. doi: 10.1681/ASN.2006020132. Epub 2006 Nov 29. J Am Soc Nephrol. 2007. PMID: 17135396
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B, Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD, Rosenthal W, Klussmann E. Hundsrucker C, et al. Among authors: stefan e. Biochem J. 2006 Jun 1;396(2):297-306. doi: 10.1042/BJ20051970. Biochem J. 2006. PMID: 16483255 Free PMC article.
Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway.
Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, Zezula J. Gsandtner I, et al. Among authors: stefan e. J Biol Chem. 2005 Sep 9;280(36):31898-905. doi: 10.1074/jbc.M506515200. Epub 2005 Jul 18. J Biol Chem. 2005. PMID: 16027149 Free article.
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti G, Bachmann S, Rosenthal W, Klussmann E. Henn V, et al. Among authors: stefan e. J Biol Chem. 2004 Jun 18;279(25):26654-65. doi: 10.1074/jbc.M312835200. Epub 2004 Mar 22. J Biol Chem. 2004. PMID: 15037626 Free article.