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Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I).
Götz C, Pfeiffer R, Tigges J, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E. Götz C, et al. Among authors: edwards rj. Exp Dermatol. 2012 May;21(5):358-63. doi: 10.1111/j.1600-0625.2012.01486.x. Exp Dermatol. 2012. PMID: 22509833
Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes.
Götz C, Pfeiffer R, Tigges J, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Pease C, Goebel C, Hewitt N, Fritsche E. Götz C, et al. Among authors: edwards rj. Exp Dermatol. 2012 May;21(5):364-9. doi: 10.1111/j.1600-0625.2012.01478.x. Exp Dermatol. 2012. PMID: 22509834
Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue.
Raunio H, Hakkola J, Hukkanen J, Lassila A, Päivärinta K, Pelkonen O, Anttila S, Piipari R, Boobis A, Edwards RJ. Raunio H, et al. Among authors: edwards rj. Exp Toxicol Pathol. 1999 Jul;51(4-5):412-7. doi: 10.1016/S0940-2993(99)80031-1. Exp Toxicol Pathol. 1999. PMID: 10445407 Review.
Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems.
Salonen JS, Nyman L, Boobis AR, Edwards RJ, Watts P, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Guillouzo A, Corcos L, Goldfarb PS, Lewis DF, Taavitsainen P, Pelkonen O. Salonen JS, et al. Among authors: edwards rj. Drug Metab Dispos. 2003 Sep;31(9):1093-102. doi: 10.1124/dmd.31.9.1093. Drug Metab Dispos. 2003. PMID: 12920164
An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant.
Andersson TB, Sjöberg H, Hoffmann KJ, Boobis AR, Watts P, Edwards RJ, Lake BG, Price RJ, Renwick AB, Gómez-Lechón MJ, Castell JV, Ingelman-Sundberg M, Hidestrand M, Goldfarb PS, Lewis DF, Corcos L, Guillouzo A, Taavitsainen P, Pelkonen O. Andersson TB, et al. Among authors: edwards rj. Drug Metab Dispos. 2001 May;29(5):712-20. Drug Metab Dispos. 2001. PMID: 11302938
427 results