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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.
Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ. Brenner MB, et al. Among authors: efanov am. Ann N Y Acad Sci. 2003 Dec;1009:332-40. doi: 10.1196/annals.1304.042. Ann N Y Acad Sci. 2003. PMID: 15028607
Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5.
Farb TB, Adeva M, Beauchamp TJ, Cabrera O, Coates DA, Meredith TD, Droz BA, Efanov A, Ficorilli JV, Gackenheimer SL, Martinez-Grau MA, Molero V, Ruano G, Statnick MA, Suter TM, Syed SK, Toledo MA, Willard FS, Zhou X, Bokvist KB, Barrett DG. Farb TB, et al. Among authors: efanov a. Endocrinology. 2017 Nov 1;158(11):3859-3873. doi: 10.1210/en.2017-00639. Endocrinology. 2017. PMID: 28938487
Two generations of insulinotropic imidazoline compounds.
Efendic S, Efanov AM, Berggren PO, Zaitsev SV. Efendic S, et al. Among authors: efanov am. Diabetes. 2002 Dec;51 Suppl 3:S448-54. doi: 10.2337/diabetes.51.2007.s448. Diabetes. 2002. PMID: 12475789 Review.
Insulinotropic activity of the imidazoline derivative RX871024 in the diabetic GK rat.
Efanov AM, Appelskog IB, Abdel-Halim SM, Khan A, Bränström R, Larsson O, Ostenson CG, Mest HJ, Berggren PO, Efendic S, Zaitsev SV. Efanov AM, et al. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E117-24. doi: 10.1152/ajpendo.000031.2001. Am J Physiol Endocrinol Metab. 2002. PMID: 11739091
Neuronal calcium sensor-1 potentiates glucose-dependent exocytosis in pancreatic beta cells through activation of phosphatidylinositol 4-kinase beta.
Gromada J, Bark C, Smidt K, Efanov AM, Janson J, Mandic SA, Webb DL, Zhang W, Meister B, Jeromin A, Berggren PO. Gromada J, et al. Among authors: efanov am. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10303-8. doi: 10.1073/pnas.0504487102. Epub 2005 Jul 12. Proc Natl Acad Sci U S A. 2005. PMID: 16014415 Free PMC article.
Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels.
Juhl K, Efanov AM, Olsen HL, Gromada J. Juhl K, et al. Among authors: efanov am. Biochem Biophys Res Commun. 2003 Oct 17;310(2):274-9. doi: 10.1016/j.bbrc.2003.09.018. Biochem Biophys Res Commun. 2003. PMID: 14521906
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J. Olsen HL, et al. Among authors: efanov am. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5187-92. doi: 10.1073/pnas.0931282100. Epub 2003 Apr 16. Proc Natl Acad Sci U S A. 2003. PMID: 12700357 Free PMC article.
Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel.
Ma W, Chen X, Cerne R, Syed SK, Ficorilli JV, Cabrera O, Obukhov AG, Efanov AM. Ma W, et al. Among authors: efanov am. J Biol Chem. 2019 Feb 22;294(8):2935-2946. doi: 10.1074/jbc.RA118.005504. Epub 2018 Dec 26. J Biol Chem. 2019. PMID: 30587572 Free PMC article.
GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function.
Lin HV, Wang J, Wang J, Li W, Wang X, Alston JT, Thomas MK, Briere DA, Syed SK, Efanov AM. Lin HV, et al. Among authors: efanov am. Mol Metab. 2018 May;11:205-211. doi: 10.1016/j.molmet.2018.02.008. Epub 2018 Feb 23. Mol Metab. 2018. PMID: 29506910 Free PMC article.
GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism.
Lin HV, Efanov AM, Fang X, Beavers LS, Wang X, Wang J, Gonzalez Valcarcel IC, Ma T. Lin HV, et al. Among authors: efanov am. PLoS One. 2016 Jun 20;11(6):e0157298. doi: 10.1371/journal.pone.0157298. eCollection 2016. PLoS One. 2016. PMID: 27322810 Free PMC article.
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