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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 2
2004 1
2006 2
2007 1
2008 1
2009 1
2010 1
2012 2
2013 2
2014 3
2015 6
2016 15
2017 8
2018 6
2019 6
2020 5
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Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing: The MI-GENES Study (Myocardial Infarction Genes).
Brown SN, Jouni H, Marroush TS, Kullo IJ. Brown SN, et al. Circ Cardiovasc Genet. 2017 Aug;10(4):e001613. doi: 10.1161/CIRCGENETICS.116.001613. Circ Cardiovasc Genet. 2017. PMID: 28779015 Free PMC article.
BACKGROUND: Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influences information seeking and information sharing is not known. We hypothesized that disclosing genetic
BACKGROUND: Whether disclosing genetic risk for coronary heart disease (CHD) to individuals influe …
Genome-wide associations for birth weight and correlations with adult disease.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ETH, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RCW, Tam CHT, Tam WH; CHARGE Consortium Hematology Working Group, Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EVR, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonas-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium, Lowe WL Jr, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén EE, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Jarvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Davey Smith G, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM. Horikoshi M, et al. Nature. 2016 Oct 13;538(7624):248-252. doi: 10.1038/nature19806. Epub 2016 Sep 28. Nature. 2016. PMID: 27680694 Free PMC article.
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. ...We demonst …
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly ass …
CYP2C19 genotype, physician prescribing pattern, and risk for long QT on serotonin selective reuptake inhibitors.
Petry N, Lupu R, Gohar A, Larson EA, Peterson C, Williams V, Zhao J, Wilke RA, Hines LJ. Petry N, et al. Pharmacogenomics. 2019 Apr;20(5):343-351. doi: 10.2217/pgs-2018-0156. Epub 2019 Apr 15. Pharmacogenomics. 2019. PMID: 30983508 Free PMC article. Clinical Trial.
Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study.
Meyer K, Volkmann A, Hufnagel M, Schachinger E, Klau S, Horstmann J, Berner R, Fischer M, Lehner A, Haas N, Ulrich S, Jakob A. Meyer K, et al. BMC Pediatr. 2019 Feb 26;19(1):66. doi: 10.1186/s12887-019-1438-2. BMC Pediatr. 2019. PMID: 30808315 Free PMC article.
BACKGROUND: In Kawasaki disease (KD), a vasculitis of unknown etiology, the most serious complication is the development of coronary artery aneurysm (CAA). ...CONCLUSION: Our findings indicate breastfeeding and vitamin D supplementation to have protective effects
BACKGROUND: In Kawasaki disease (KD), a vasculitis of unknown etiology, the most serious complication is the development of corona
Frequency and clinical outcomes of CYP2C19 genotype-guided escalation and de-escalation of antiplatelet therapy in a real-world clinical setting.
Martin J, Williams AK, Klein MD, Sriramoju VB, Madan S, Rossi JS, Clarke M, Cicci JD, Cavallari LH, Weck KE, Stouffer GA, Lee CR. Martin J, et al. Genet Med. 2020 Jan;22(1):160-169. doi: 10.1038/s41436-019-0611-1. Epub 2019 Jul 18. Genet Med. 2020. PMID: 31316169 Free PMC article. Clinical Trial.
PURPOSE: To evaluate the frequency and clinical impact of switches in antiplatelet therapy following implementation of CYP2C19 genotyping after percutaneous coronary intervention (PCI). ...De-escalation to clopidogrel in patients without a nonfunctional allele appea …
PURPOSE: To evaluate the frequency and clinical impact of switches in antiplatelet therapy following implementation of CYP2C19 genoty …
Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.
Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Döring Y, et al. Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27. Circulation. 2017. PMID: 28450349 Free PMC article.
Finally, we analyzed associations of common genetic variants at the CXCR4 locus with the risk for coronary heart disease, along with CXCR4 transcript expression in human atherosclerotic plaques. ...Regression analyses in humans (n=259 796) ident …
Finally, we analyzed associations of common genetic variants at the CXCR4 locus with the risk for coronary heart
Genotype-Phenotype Association and Impact on Outcomes following Guided De-Escalation of Anti-Platelet Treatment in Acute Coronary Syndrome Patients: The TROPICAL-ACS Genotyping Substudy.
Gross L, Trenk D, Jacobshagen C, Krieg A, Gawaz M, Massberg S, Baylacher M, Aradi D, Stimpfle F, Hromek J, Vogelgesang A, Hadamitzky M, Sibbing D, Geisler T. Gross L, et al. Thromb Haemost. 2018 Sep;118(9):1656-1667. doi: 10.1055/s-0038-1667337. Epub 2018 Aug 13. Thromb Haemost. 2018. PMID: 30103241 Clinical Trial.
BACKGROUND:  Phenotype-guided de-escalation (PGDE) of P2Y(12)-inhibitor treatment with an early switch from prasugrel to clopidogrel was identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous co
BACKGROUND:  Phenotype-guided de-escalation (PGDE) of P2Y(12)-inhibitor treatment with an early switch from prasugrel to clopidogrel was ide …
Down-regulated of SREBP-1 in circulating leukocyte is a risk factor for atherosclerosis: a case control study.
Peng C, Lei P, Li X, Xie H, Yang X, Zhang T, Cao Z, Zhang J. Peng C, et al. Lipids Health Dis. 2019 Oct 14;18(1):177. doi: 10.1186/s12944-019-1125-1. Lipids Health Dis. 2019. PMID: 31610782 Free PMC article.
SREBPs mRNA in circulating leucocyte and carotid plaques, along with various risk factors that associated with Coronary Atherosclerotic Disease (CAD) were investigated in a central Chinese cohort. METHODS: A total of 218 coronary atherosclerotic dis
SREBPs mRNA in circulating leucocyte and carotid plaques, along with various risk factors that associated with Coronary Athero …
Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction.
Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ, Ye S. Yang W, et al. PLoS Genet. 2016 Jul 7;12(7):e1006127. doi: 10.1371/journal.pgen.1006127. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27389912 Free PMC article.
Genome-wide association studies have revealed an association between coronary heart disease (CHD) and genetic variation on chromosome 13q34, with the lead single nucleotide polymorphism rs4773144 residing in the COL4A2 gene in this genomi …
Genome-wide association studies have revealed an association between coronary heart disease (CHD) and genetic
Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study.
Kullo IJ, Jouni H, Olson JE, Montori VM, Bailey KR. Kullo IJ, et al. BMC Med Genomics. 2015 Aug 15;8:51. doi: 10.1186/s12920-015-0122-0. BMC Med Genomics. 2015. PMID: 26271327 Free PMC article. Clinical Trial.
We describe design of the Myocardial Infarction Genes (MI-GENES) Study, a randomized clinical trial to assess whether disclosing a GRS for coronary heart disease (CHD) leads to lowering of low-density lipoprotein chol …
We describe design of the Myocardial Infarction Genes (MI-GENES) Study, a randomized clinical trial to as …
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