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Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection.
Baidya S, Nishimoto Y, Sato S, Shimada Y, Sakurai N, Nonaka H, Noguchi K, Kido M, Tadano S, Ishikawa K, Li K, Okubo A, Yamada T, Orba Y, Sasaki M, Sawa H, Miyamoto H, Takada A, Nakamura T, Takaoka A. Baidya S, et al. Viruses. 2021 Aug 24;13(9):1674. doi: 10.3390/v13091674. Viruses. 2021. PMID: 34578256 Free PMC article.
The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been reported that a hydrolysa …
The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replic …
Antiviral activity of carboxyethylgermanium sesquioxide (Ge-132) in mice infected with influenza virus.
Aso H, Suzuki F, Ebina T, Ishida N. Aso H, et al. J Biol Response Mod. 1989 Apr;8(2):180-9. J Biol Response Mod. 1989. PMID: 2471817
The protective effect of carboxyethylgermanium sesquioxide (Ge-132) in mice infected with a mouse-adapted strain of influenza virus (H2N2) was investigated. ...In addition, NK cells stimulated with Ge-132 in vivo showed kill …
The protective effect of carboxyethylgermanium sesquioxide (Ge-132) in mice infected with a mouse-adapted strain …
Effects of proxigermanium on interferon production and 2',5'-oligoadenylate synthetase activity in the lung of influenza virus-infected mice and in virus-infected human peripheral blood mononuclear cell cultures.
Ishiwata Y, Yokochi S, Suzuki E, Michishita H, Tashita A, Asano K, Mitani T, Kurono M. Ishiwata Y, et al. Arzneimittelforschung. 1990 Aug;40(8):896-9. Arzneimittelforschung. 1990. PMID: 1700719
Proxigermanium (SK-818) is a synthesized organic germanium compound having various biological activities. The effects of proxigermanium on interferon (IFN) production in mice infected with influenza virus and virus-infected human peripher …
Proxigermanium (SK-818) is a synthesized organic germanium compound having various biological activities. The effects of proxigermani …