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Effect of Genetic African Ancestry on eGFR and Kidney Disease.
Udler MS, Nadkarni GN, Belbin G, Lotay V, Wyatt C, Gottesman O, Bottinger EP, Kenny EE, Peter I. Udler MS, et al. J Am Soc Nephrol. 2015 Jul;26(7):1682-92. doi: 10.1681/ASN.2014050474. Epub 2014 Oct 27. J Am Soc Nephrol. 2015. PMID: 25349204 Free PMC article.
Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in kidney function and related disease risk, but the relative importance of these factors remains unclear. ...In contrast, APOL1 risk …
Self-reported ancestry, genetically determined ancestry, and APOL1 polymorphisms are associated with variation in ki
APOL1 risk variants, race, and progression of chronic kidney disease.
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ; AASK Study Investigators; CRIC Study Investigators. Parsa A, et al. N Engl J Med. 2013 Dec 5;369(23):2183-96. doi: 10.1056/NEJMoa1310345. Epub 2013 Nov 9. N Engl J Med. 2013. PMID: 24206458 Free PMC article.
METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. In the African American Study of Kidney Disease and Hypertension (AASK), we evaluate …
METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chr …
APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.
Matsha TE, Kengne AP, Masconi KL, Yako YY, Erasmus RT. Matsha TE, et al. BMC Genet. 2015 Jun 26;16:69. doi: 10.1186/s12863-015-0228-6. BMC Genet. 2015. PMID: 26112018 Free PMC article.
APOL1 risk variants (G1: rs60910145 and rs73885319; G2: rs71785313) were genotyped in 859 African mixed ancestry individuals using allele-specific TaqMan technology. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Di
APOL1 risk variants (G1: rs60910145 and rs73885319; G2: rs71785313) were genotyped in 859 African mixed ancestry individuals u …
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
Cooke Bailey JN, Wilson S, Brown-Gentry K, Goodloe R, Crawford DC. Cooke Bailey JN, et al. Pac Symp Biocomput. 2016;21:285-96. Pac Symp Biocomput. 2016. PMID: 26776194 Free PMC article.
Kidney disease is a well-known health disparity in the United States where African Americans are affected at higher rates compared with other groups such as European Americans and Mexican Americans. ...In a precision medicine setting, it is important to consi
Kidney disease is a well-known health disparity in the United States where African Americans are affected at higher rat
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.
Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, Rich SS, Smith JD, Boerwinkle E, Rosamond WD, Ito K, Lanzkron S, Coresh J, Correa A, Sarto GE, Key NS, Jacobs DR, Kathiresan S, Bibbins-Domingo K, Kshirsagar AV, Wilson JG, Reiner AP. Naik RP, et al. JAMA. 2014 Nov 26;312(20):2115-25. doi: 10.1001/jama.2014.15063. JAMA. 2014. PMID: 25393378 Free PMC article.
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans. ...These findings suggest that SCT may …
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To descr …
APOL1 Genotype and Renal Function of Black Living Donors.
Doshi MD, Ortigosa-Goggins M, Garg AX, Li L, Poggio ED, Winkler CA, Kopp JB. Doshi MD, et al. J Am Soc Nephrol. 2018 Apr;29(4):1309-1316. doi: 10.1681/ASN.2017060658. Epub 2018 Jan 16. J Am Soc Nephrol. 2018. PMID: 29339549 Free PMC article.
Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal function in black living kidney donors and evaluated whether this genotype …
Black living kidney donors are at higher risk of developing kidney disease than white donors. We examined the effect
Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study.
Lunyera J, Davenport CA, Pendergast J, Musani SK, Bhavsar NA, Sims M, Mwasongwe S, Wolf M, Diamantidis CJ, Boulware LE, Scialla JJ. Lunyera J, et al. J Clin Endocrinol Metab. 2019 Jun 1;104(6):2267-2276. doi: 10.1210/jc.2018-01747. J Clin Endocrinol Metab. 2019. PMID: 30668751 Free PMC article.
BACKGROUND: 25-hydroxyvitamin D [25(OH)D] is lower in black compared with white Americans but is not consistently associated with outcomes in this group, possibly due to genetic and other biological differences. We examined the association of plasma 25(OH)D and rena …
BACKGROUND: 25-hydroxyvitamin D [25(OH)D] is lower in black compared with white Americans but is not consistently associated with outcomes i …
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa.
Okpechi IG, Rayner BL, van der Merwe L, Mayosi BM, Adeyemo A, Tiffin N, Ramesar R. Okpechi IG, et al. PLoS One. 2010 Feb 5;5(2):e9086. doi: 10.1371/journal.pone.0009086. PLoS One. 2010. PMID: 20140086 Free PMC article.
BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. ...Also, the haplotype GAAC had a modest effec
BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease ( …
Heritable influence of DBH on adrenergic and renal function: twin and disease studies.
Pasha DN, Davis JT, Rao F, Chen Y, Wen G, Fung MM, Mahata M, Zhang K, Trzebinska D, Mustapic M, Hightower CM, Lipkowitz MS, Ji M, Ziegler MG, Nievergelt CM, O'Connor DT. Pasha DN, et al. PLoS One. 2013 Dec 31;8(12):e82956. doi: 10.1371/journal.pone.0082956. eCollection 2013. PLoS One. 2013. PMID: 24391727 Free PMC article. Clinical Trial.
Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis probed reproducibility of DBH genetic effects. Effect of DBH genetic variation on renal disease was tested …
Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis pr …
APOL1 risk genotype in Europe: Data in patients with focal segmental glomerulosclerosis and after renal transplantation.
Servais A, Gribouval O, Gaillard F, Antignac C. Servais A, et al. Nephrol Ther. 2019 Apr;15 Suppl 1:S85-S89. doi: 10.1016/j.nephro.2019.02.005. Nephrol Ther. 2019. PMID: 30981401
Effects of APOL1 are independent of other traditional risk factors. Recently it was shown that black living kidney donors homozygous for APOL1 high-risk alleles have significantly lower glomerular filtration rate and increased risk of end-stage renal disease
Effects of APOL1 are independent of other traditional risk factors. Recently it was shown that black living kidney donors homo
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