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The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study.
Kintu C, Soremekun O, Kamiza AB, Kalungi A, Mayanja R, Kalyesubula R, Bagaya S B, Jjingo D, Fabian J, Gill D, Nyirenda M, Nitsch D, Chikowore T, Fatumo S. Kintu C, et al. EBioMedicine. 2023 Apr;90:104537. doi: 10.1016/j.ebiom.2023.104537. Epub 2023 Mar 29. EBioMedicine. 2023. PMID: 37001235 Free PMC article.
INTERPRETATION: In this African ancestry population, genetically predicted higher LDL-C and TC are causally associated with higher eGFR levels, which may suggest that the relationship between LDL, TC and kidney function may be U-shaped. ...In ad …
INTERPRETATION: In this African ancestry population, genetically predicted higher LDL-C and TC are causally associated …
Effect of Genetic African Ancestry on eGFR and Kidney Disease.
Udler MS, Nadkarni GN, Belbin G, Lotay V, Wyatt C, Gottesman O, Bottinger EP, Kenny EE, Peter I. Udler MS, et al. J Am Soc Nephrol. 2015 Jul;26(7):1682-92. doi: 10.1681/ASN.2014050474. Epub 2014 Oct 27. J Am Soc Nephrol. 2015. PMID: 25349204 Free PMC article.
In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m(2), and ESRD, with effects increasing with worsening disease states and the contribution of genetic African ancestry decreasing in par …
In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m(2), and ESRD, with effects
Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis.
Writing Group for the CKD Prognosis Consortium; Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Alencar de Pinho N, Anderson A, Appel LJ, Ärnlöv J, Azizi F, Bansal N, Bell S, Bilo HJG, Brunskill NJ, Carrero JJ, Chadban S, Chalmers J, Chen J, Ciemins E, Cirillo M, Ebert N, Evans M, Ferreiro A, Fu EL, Fukagawa M, Green JA, Gutierrez OM, Herrington WG, Hwang SJ, Inker LA, Iseki K, Jafar T, Jassal SK, Jha V, Kadota A, Katz R, Köttgen A, Konta T, Kronenberg F, Lee BJ, Lees J, Levin A, Looker HC, Major R, Melzer Cohen C, Mieno M, Miyazaki M, Moranne O, Muraki I, Naimark D, Nitsch D, Oh W, Pena M, Purnell TS, Sabanayagam C, Satoh M, Sawhney S, Schaeffner E, Schöttker B, Shen JI, Shlipak MG, Sinha S, Stengel B, Sumida K, Tonelli M, Valdivielso JM, van Zuilen AD, Visseren FLJ, Wang AY, Wen CP, Wheeler DC, Yatsuya H, Yamagata K, Yang JW, Young A, Zhang H, Zhang L, Levey AS, Gansevoort RT. Writing Group for the CKD Prognosis Consortium, et al. JAMA. 2023 Oct 3;330(13):1266-1277. doi: 10.1001/jama.2023.17002. JAMA. 2023. PMID: 37787795 Free PMC article.
IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximately 14% of adults in the US. ...EXPOSURES: The Chronic Kidney Disease Epidemiology Collaboration 2021 equations for eGFR
IMPORTANCE: Chronic kidney disease (low estimated glomerular filtration rate [eGFR] or albuminuria) affects approximate …
Inaxaplin for the treatment of APOL1-associated kidney disease.
Gbadegesin R, Lane B. Gbadegesin R, et al. Nat Rev Nephrol. 2023 Aug;19(8):479-480. doi: 10.1038/s41581-023-00721-0. Nat Rev Nephrol. 2023. PMID: 37106136 Free PMC article.
Chronic kidney disease (CKD) is highly prevalent World-Wide and it is an important cause of morbidity and mortality. In 2010, variants in apolipoprotein type 1 (APOL1) gene was identified as a major risk factor for higher prevalence of CKD in individuals of Afric
Chronic kidney disease (CKD) is highly prevalent World-Wide and it is an important cause of morbidity and mortality. In 2010, …
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.
Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, Rich SS, Smith JD, Boerwinkle E, Rosamond WD, Ito K, Lanzkron S, Coresh J, Correa A, Sarto GE, Key NS, Jacobs DR, Kathiresan S, Bibbins-Domingo K, Kshirsagar AV, Wilson JG, Reiner AP. Naik RP, et al. JAMA. 2014 Nov 26;312(20):2115-25. doi: 10.1001/jama.2014.15063. JAMA. 2014. PMID: 25393378 Free PMC article.
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans. ...These findings suggest that SCT may …
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To descr …
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
Cooke Bailey JN, Wilson S, Brown-Gentry K, Goodloe R, Crawford DC. Cooke Bailey JN, et al. Pac Symp Biocomput. 2016;21:285-96. Pac Symp Biocomput. 2016. PMID: 26776194 Free PMC article.
Kidney disease and quantitative trait-associated genetic variants have yet to be systematically characterized in multiple racial/ethnic groups. ...We also tested for associations between each SNP and chronic kidney disease and albuminuria using
Kidney disease and quantitative trait-associated genetic variants have yet to be systematically characterized in multip
[Kidney and HIV infection].
Plaisier E, Lescure FX, Ronco P. Plaisier E, et al. Presse Med. 2012 Mar;41(3 Pt 1):267-75. doi: 10.1016/j.lpm.2011.11.011. Epub 2012 Jan 14. Presse Med. 2012. PMID: 22245017 Review. French.
Black patients have a genetic predisposition to develop HIV-associated nephropathy. Suppression of HIV viral replication with antiretroviral therapy prevents the development of HIV-associated nephropathy or halts its progression. Kidney biopsy remains the mos
Black patients have a genetic predisposition to develop HIV-associated nephropathy. Suppression of HIV viral replication with
High risk APOL1 genotypes and kidney disease among treatment naive HIV patients at Kano, Nigeria.
Abdu A, Duarte R, Dickens C, Dix-Peek T, Bala SM, Ademola B, Naicker S. Abdu A, et al. PLoS One. 2022 Oct 13;17(10):e0275949. doi: 10.1371/journal.pone.0275949. eCollection 2022. PLoS One. 2022. PMID: 36227935 Free PMC article.
INTRODUCTION: Racial disparities are known in the occurrence of kidney disease with excess risks found among people of African descent. Apolipoprotein L1 (APOL1) gene variants G1 and G2 are associated with kidney disease among HIV infecte …
INTRODUCTION: Racial disparities are known in the occurrence of kidney disease with excess risks found among people of …
Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.
Hong X, Rosenberg AZ, Zhang B, Binns-Roemer E, David V, Lv Y, Hjorten RC, Reidy KJ, Chen TK, Wang G, Ji Y, Simpson CL, Davis RL, Kopp JB, Wang X, Winkler CA. Hong X, et al. Am J Kidney Dis. 2021 Jun;77(6):879-888.e1. doi: 10.1053/j.ajkd.2020.10.020. Epub 2020 Dec 22. Am J Kidney Dis. 2021. PMID: 33359152 Free PMC article.
RATIONALE & OBJECTIVES: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for future hypertension and chronic kidney disease (CKD). Apolipoprotein L1 (APOL1) kidney risk alleles, common amon …
RATIONALE & OBJECTIVES: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and ri …
APOL1 risk variants, race, and progression of chronic kidney disease.
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ; AASK Study Investigators; CRIC Study Investigators. Parsa A, et al. N Engl J Med. 2013 Dec 5;369(23):2183-96. doi: 10.1056/NEJMoa1310345. Epub 2013 Nov 9. N Engl J Med. 2013. PMID: 24206458 Free PMC article.
BACKGROUND: Among patients in the United States with chronic kidney disease, black patients are at increased risk for end-stage renal disease, as compared with white patients. ...In the African American Study of Kidney Disease and …
BACKGROUND: Among patients in the United States with chronic kidney disease, black patients are at increased risk for e …
33 results