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APOL1 risk variants, race, and progression of chronic kidney disease.
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT Jr, Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ; AASK Study Investigators; CRIC Study Investigators. Parsa A, et al. N Engl J Med. 2013 Dec 5;369(23):2183-96. doi: 10.1056/NEJMoa1310345. Epub 2013 Nov 9. N Engl J Med. 2013. PMID: 24206458 Free PMC article.
METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chronic kidney disease. In the African American Study of Kidney Disease and Hypertension (AASK), we evaluate …
METHODS: In two studies, we examined the effects of variants in the gene encoding apolipoprotein L1 (APOL1) on the progression of chr …
Effect of Genetic African Ancestry on eGFR and Kidney Disease.
Udler MS, Nadkarni GN, Belbin G, Lotay V, Wyatt C, Gottesman O, Bottinger EP, Kenny EE, Peter I. Udler MS, et al. J Am Soc Nephrol. 2015 Jul;26(7):1682-92. doi: 10.1681/ASN.2014050474. Epub 2014 Oct 27. J Am Soc Nephrol. 2015. PMID: 25349204 Free PMC article.
In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m(2), and ESRD, with effects increasing with worsening disease states and the contribution of genetic African ancestry decreasing in par …
In contrast, APOL1 risk haplotypes were significantly associated with CKD, eGFR<45 ml/min per 1.73 m(2), and ESRD, with effects
[Kidney and HIV infection].
Plaisier E, Lescure FX, Ronco P. Plaisier E, et al. Presse Med. 2012 Mar;41(3 Pt 1):267-75. doi: 10.1016/j.lpm.2011.11.011. Epub 2012 Jan 14. Presse Med. 2012. PMID: 22245017 Review. French.
Kidney biopsy remains the most informative diagnosis test to differentiate various forms of kidney diseases in HIV-infected patients. ...Proximal renal tubular toxicity must be further evaluated in the presence of eGFR decrease and/or hypophosphatemia
Kidney biopsy remains the most informative diagnosis test to differentiate various forms of kidney diseases in HIV-infe
Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.
Naik RP, Derebail VK, Grams ME, Franceschini N, Auer PL, Peloso GM, Young BA, Lettre G, Peralta CA, Katz R, Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P, Rich SS, Smith JD, Boerwinkle E, Rosamond WD, Ito K, Lanzkron S, Coresh J, Correa A, Sarto GE, Key NS, Jacobs DR, Kathiresan S, Bibbins-Domingo K, Kshirsagar AV, Wilson JG, Reiner AP. Naik RP, et al. JAMA. 2014 Nov 26;312(20):2115-25. doi: 10.1001/jama.2014.15063. JAMA. 2014. PMID: 25393378 Free PMC article.
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans. ...These findings suggest that SCT may …
IMPORTANCE: The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain. OBJECTIVE: To descr …
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
Cooke Bailey JN, Wilson S, Brown-Gentry K, Goodloe R, Crawford DC. Cooke Bailey JN, et al. Pac Symp Biocomput. 2016;21:285-96. Pac Symp Biocomput. 2016. PMID: 26776194 Free PMC article.
Kidney disease and quantitative trait-associated genetic variants have yet to be systematically characterized in multiple racial/ethnic groups. ...We also tested for associations between each SNP and chronic kidney disease and albuminuria using
Kidney disease and quantitative trait-associated genetic variants have yet to be systematically characterized in multip
Modifiers of Plasma 25-Hydroxyvitamin D and Chronic Kidney Disease Outcomes in Black Americans: The Jackson Heart Study.
Lunyera J, Davenport CA, Pendergast J, Musani SK, Bhavsar NA, Sims M, Mwasongwe S, Wolf M, Diamantidis CJ, Boulware LE, Scialla JJ. Lunyera J, et al. J Clin Endocrinol Metab. 2019 Jun 1;104(6):2267-2276. doi: 10.1210/jc.2018-01747. J Clin Endocrinol Metab. 2019. PMID: 30668751 Free PMC article.
METHODS: We studied associations between baseline 25(OH)D with (i) annual rate of estimated glomerular filtration rate (eGFR) decline and (ii) incident chronic kidney disease (CKD) in the Jackson Heart Study, a prospective cohort of black Americans. ...Overal …
METHODS: We studied associations between baseline 25(OH)D with (i) annual rate of estimated glomerular filtration rate (eGFR) decline …
Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.
Hong X, Rosenberg AZ, Zhang B, Binns-Roemer E, David V, Lv Y, Hjorten RC, Reidy KJ, Chen TK, Wang G, Ji Y, Simpson CL, Davis RL, Kopp JB, Wang X, Winkler CA. Hong X, et al. Am J Kidney Dis. 2021 Jun;77(6):879-888.e1. doi: 10.1053/j.ajkd.2020.10.020. Epub 2020 Dec 22. Am J Kidney Dis. 2021. PMID: 33359152
RATIONALE & OBJECTIVES: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for future hypertension and chronic kidney disease (CKD). Apolipoprotein L1 (APOL1) kidney risk alleles, common among Black …
RATIONALE & OBJECTIVES: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for …
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa.
Okpechi IG, Rayner BL, van der Merwe L, Mayosi BM, Adeyemo A, Tiffin N, Ramesar R. Okpechi IG, et al. PLoS One. 2010 Feb 5;5(2):e9086. doi: 10.1371/journal.pone.0009086. PLoS One. 2010. PMID: 20140086 Free PMC article.
BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. ...A number of clinical and experimental studies …
BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease ( …
Design and methods of the prevalence and pharmacogenomics of tenofovir nephrotoxicity in HIV-positive adults in south-western Nigeria study.
Hassan MO, Duarte R, Mabayoje VO, Dickens C, Lasisi AO, Naicker S. Hassan MO, et al. BMC Nephrol. 2020 Oct 16;21(1):436. doi: 10.1186/s12882-020-02082-3. BMC Nephrol. 2020. PMID: 33066744 Free PMC article.
BACKGROUND: Individuals of African descent are at higher risk of developing kidney disease than their European counterparts, and HIV infection is associated with increased risk of nephropathy. ...Blood and urine samples for measurements of severity of HIV …
BACKGROUND: Individuals of African descent are at higher risk of developing kidney disease than their European counterp …
APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.
Matsha TE, Kengne AP, Masconi KL, Yako YY, Erasmus RT. Matsha TE, et al. BMC Genet. 2015 Jun 26;16:69. doi: 10.1186/s12863-015-0228-6. BMC Genet. 2015. PMID: 26112018 Free PMC article.
BACKGROUND: The frequencies of apolipoprotein L1 (APOL1) variants and their associations with chronic kidney disease (CKD) vary substantially in populations from Africa. ...Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Rena …
BACKGROUND: The frequencies of apolipoprotein L1 (APOL1) variants and their associations with chronic kidney disease (CKD) var …
28 results