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36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhag… See abstract for full author list ➔ Bateman RM, et al. Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Crit Care. 2016. PMID: 27885969 Free PMC article.
Shabanov, S. Polovnikov, V. Moroz P103 - In vitro evaluation of amikacin inhale and commercial nebulizers in a mechanical ventilator N. ...Kleinsasser P114 - Filtering of red blood cells reduces the inflammatory response of pulmonary cells in an in vitro
Shabanov, S. Polovnikov, V. Moroz P103 - In vitro evaluation of amikacin inhale and commercial nebulizers in a mechanical vent …
Effects of insulin on human pancreatic cancer progression modeled in vitro.
Chan MT, Lim GE, Skovsø S, Yang YH, Albrecht T, Alejandro EU, Hoesli CA, Piret JM, Warnock GL, Johnson JD. Chan MT, et al. BMC Cancer. 2014 Nov 6;14:814. doi: 10.1186/1471-2407-14-814. BMC Cancer. 2014. PMID: 25373319 Free PMC article.
However, the actions of insulin at the various stages of pancreatic cancer progression remain poorly defined. METHODS: Here, we examined the effects of a range of insulin doses on signalling, proliferation and survival in three human
However, the actions of insulin at the various stages of pancreatic cancer progression remain poorly defined. ME …
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.
Zemva J, Pfaff D, Groener JB, Fleming T, Herzig S, Teleman A, Nawroth PP, Tyedmers J. Zemva J, et al. Exp Clin Endocrinol Diabetes. 2019 Apr;127(4):203-214. doi: 10.1055/s-0043-122382. Epub 2018 Feb 8. Exp Clin Endocrinol Diabetes. 2019. PMID: 29421830 Review.
Here we review the current knowledge about the molecular effects that MG can induce in a cell. Within the mammalian system, we will focus mostly on the metabolic effects MG exerts when applied systemically to rodents or when applied in vitro to panc
Here we review the current knowledge about the molecular effects that MG can induce in a cell. Within the mammalian system, we will f …
Radiomanganese PET Detects Changes in Functional beta-Cell Mass in Mouse Models of Diabetes.
Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W. Hernandez R, et al. Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17. Diabetes. 2017. PMID: 28515126 Free PMC article.
The noninvasive measurement of functional beta-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted insulin-producing cells. ...We investigated the whole-body distribution of (52 …
The noninvasive measurement of functional beta-cell mass would be clinically valuable for monitoring the progression of type 1 and ty …
Insulin-like growth factor 1 receptor promotes the growth and chemoresistance of pancreatic cancer.
Tian X, Hao K, Qin C, Xie K, Xie X, Yang Y. Tian X, et al. Dig Dis Sci. 2013 Sep;58(9):2705-12. doi: 10.1007/s10620-013-2673-2. Epub 2013 Apr 16. Dig Dis Sci. 2013. PMID: 23589145
BACKGROUND: Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic cancer. ...METHODS: Pancreatic cancer cells expressing IGF1R shRNA were established, and the cell proliferation, colony forma …
BACKGROUND: Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic can
LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2.
Jia G, Wang Y, Lin C, Lai S, Dai H, Wang Z, Dai L, Su H, Song Y, Zhang N, Feng Y, Tang B. Jia G, et al. J Exp Clin Cancer Res. 2021 Sep 22;40(1):299. doi: 10.1186/s13046-021-02090-7. J Exp Clin Cancer Res. 2021. Retraction in: J Exp Clin Cancer Res. 2023 Mar 2;42(1):54. doi: 10.1186/s13046-023-02626-z. PMID: 34551796 Free PMC article. Retracted.
Cancer cell proliferation, migration, invasion, and chemoresistance were evaluated by cell counting kit 8 (CCK8), colony formation, transwell, and chemosensitivity assays. ...LNCAROD significantly promoted HCC cell proliferation, migration, invasion, and chemoresistance bo
Cancer cell proliferation, migration, invasion, and chemoresistance were evaluated by cell counting kit 8 (CCK8), colony formation, t
mTOR inhibition induces EGFR feedback activation in association with its resistance to human pancreatic cancer.
Wei F, Zhang Y, Geng L, Zhang P, Wang G, Liu Y. Wei F, et al. Int J Mol Sci. 2015 Feb 3;16(2):3267-82. doi: 10.3390/ijms16023267. Int J Mol Sci. 2015. PMID: 25654224 Free PMC article.
Additionally, we found that AZD8055-induced transient AKT inhibition increased the expression and activation of epidermal growth factor receptor (EGFR) by releasing its transcriptional factors Fork-head box O 1/3a (FoxO1/3a), which might contribute to cell resistance to AZD8055. …
Additionally, we found that AZD8055-induced transient AKT inhibition increased the expression and activation of epidermal growth factor rece …
Inhibition of circular JUN prevents the proliferation and invasion of glioblastoma via miR-3064-IGFBP5 axis.
Zhang Y, Liu S, Wu C, Gao X, Zhao H, Li O, Gao F. Zhang Y, et al. J Cell Mol Med. 2024 Sep;28(18):e70098. doi: 10.1111/jcmm.70098. J Cell Mol Med. 2024. PMID: 39307884 Free PMC article.
Subsequently, we engineered GBM cell lines with stable circJUN knockout or overexpression, and transfected them with miR-3064 mimic/inhibitor or IGFBP5 small interfering RNA (siRNA)/expression vector to elucidate the molecular mechanisms governing GBM proliferation and invasion. …
Subsequently, we engineered GBM cell lines with stable circJUN knockout or overexpression, and transfected them with miR-3064 mimic/inhibito …
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic beta-cells.
Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM. Brereton MF, et al. Nat Commun. 2016 Nov 24;7:13496. doi: 10.1038/ncomms13496. Nat Commun. 2016. PMID: 27882918 Free PMC article.
Insulin secretion from pancreatic beta-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including beta-cells. ...Sulphonylurea therapy rapidly normalizes blood glucose levels, dissipates glycoge
Insulin secretion from pancreatic beta-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleteriou
Genetic blockade of the insulin-like growth factor 1 receptor for human malignancy.
Adachi Y, Lee CT, Carbone DP. Adachi Y, et al. Novartis Found Symp. 2004;262:177-89; discussion 190-2, 265-8. Novartis Found Symp. 2004. PMID: 15562829 Review.
Growth factor receptor signals, including insulin-like growth factor (IGF)-1 receptor (IGF-1R), are required for carcinogenesis and tumour progression in many human malignancies. ...The truncated receptors were also cloned into tetracycline regulated expressi …
Growth factor receptor signals, including insulin-like growth factor (IGF)-1 receptor (IGF-1R), are required for carcinogenesis and t …
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