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Effects of insulin on human pancreatic cancer progression modeled in vitro.
Chan MT, Lim GE, Skovsø S, Yang YH, Albrecht T, Alejandro EU, Hoesli CA, Piret JM, Warnock GL, Johnson JD. Chan MT, et al. BMC Cancer. 2014 Nov 6;14:814. doi: 10.1186/1471-2407-14-814. BMC Cancer. 2014. PMID: 25373319 Free PMC article.
However, the actions of insulin at the various stages of pancreatic cancer progression remain poorly defined. METHODS: Here, we examined the effects of a range of insulin doses on signalling, proliferation and survival in three human …
However, the actions of insulin at the various stages of pancreatic cancer progression remain poorly defined. ME …
LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2.
Jia G, Wang Y, Lin C, Lai S, Dai H, Wang Z, Dai L, Su H, Song Y, Zhang N, Feng Y, Tang B. Jia G, et al. J Exp Clin Cancer Res. 2021 Sep 22;40(1):299. doi: 10.1186/s13046-021-02090-7. J Exp Clin Cancer Res. 2021. PMID: 34551796 Free PMC article. Retracted.
The present work was aimed to explore the regulatory functions and mechanisms of LncRNA LNCAROD in HCC progression and chemotherapeutic response. METHODS: The expression of LNCAROD in HCC tissues and cell lines were detected by quantitative reverse transcription PCR (qPCR) …
The present work was aimed to explore the regulatory functions and mechanisms of LncRNA LNCAROD in HCC progression and chemotherapeut …
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.
Zemva J, Pfaff D, Groener JB, Fleming T, Herzig S, Teleman A, Nawroth PP, Tyedmers J. Zemva J, et al. Exp Clin Endocrinol Diabetes. 2019 Apr;127(4):203-214. doi: 10.1055/s-0043-122382. Epub 2018 Feb 8. Exp Clin Endocrinol Diabetes. 2019. PMID: 29421830 Review.
Here we review the current knowledge about the molecular effects that MG can induce in a cell. Within the mammalian system, we will focus mostly on the metabolic effects MG exerts when applied systemically to rodents or when applied in vitro to pancreatic …
Here we review the current knowledge about the molecular effects that MG can induce in a cell. Within the mammalian system, we will f …
An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation.
Casteels T, Zhang Y, Frogne T, Sturtzel C, Lardeau CH, Sen I, Liu X, Hong S, Pauler FM, Penz T, Brandstetter M, Barbieux C, Berishvili E, Heuser T, Bock C, Riedel CG, Meyer D, Distel M, Hecksher-Sørensen J, Li J, Kubicek S. Casteels T, et al. Mol Metab. 2021 Dec;54:101329. doi: 10.1016/j.molmet.2021.101329. Epub 2021 Aug 25. Mol Metab. 2021. PMID: 34454092 Free PMC article.
Lack of methods to easily model this process in vitro, however, have hindered progress into the identification of key downstream targets and potential inhibitors. ...Validation experiments were performed in a murine alpha-cell line as well as in primary murin …
Lack of methods to easily model this process in vitro, however, have hindered progress into the identification of key d …
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Bateman RM, Sharpe MD, Jagger JE, Ellis CG, Solé-Violán J, López-Rodríguez M, Herrera-Ramos E, Ruíz-Hernández J, Borderías L, Horcajada J, González-Quevedo N, Rajas O, Briones M, Rodríguez de Castro F, Rodríguez Gallego C, Esen F, Orhun G, Ergin Ozcan P, Senturk E, Ugur Yilmaz C, Orhan N, Arican N, Kaya M, Kucukerden M, Giris M, Akcan U, Bilgic Gazioglu S, Tuzun E, Riff R, Naamani O, Douvdevani A, Takegawa R, Yoshida H, Hirose T, Yamamoto N, Hagiya H, Ojima M, Akeda Y, Tasaki O, Tomono K, Shimazu T, Ono S, Kubo T, Suda S, Ueno T, Ikeda T, Hirose T, Ogura H, Takahashi H, Ojima M, Kang J, Nakamura Y, Kojima T, Shimazu T, Ikeda T, Suda S, Izutani Y, Ueno T, Ono S, Taniguchi T, O M, Dinter C, Lotz J, Eilers B, Wissmann C, Lott R, Meili MM, Schuetz PS, Hawa H, Sharshir M, Aburageila M, Salahuddin N, Chantziara V, Georgiou S, Tsimogianni A, Alexandropoulos P, Vassi A, Lagiou F, Valta M, Micha G, Chinou E, Michaloudis G, Kodaira A, Ikeda T, Ono S, Ueno T, Suda S, Izutani Y, Imaizumi H, De la Torre-Prados MV, Garcia-De la Torre A, Enguix-Armada A, Puerto-Morlan A, Perez-Valero V, Garcia-Alcantara A, Bolton N, Dudziak J, Bonney S, Tridente A, Nee P, Nicolaes G, Wiewel M, Schultz M, Wildhag… See abstract for full author list ➔ Bateman RM, et al. Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Crit Care. 2016. PMID: 27885969 Free PMC article.
Hoermann P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. ...K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk P268 - Tight junction's protei …
Hoermann P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics S. Faenza, D. Ricci, E. Mancini, C. Gemell …
Insulin-like growth factor 1 receptor promotes the growth and chemoresistance of pancreatic cancer.
Tian X, Hao K, Qin C, Xie K, Xie X, Yang Y. Tian X, et al. Dig Dis Sci. 2013 Sep;58(9):2705-12. doi: 10.1007/s10620-013-2673-2. Epub 2013 Apr 16. Dig Dis Sci. 2013. PMID: 23589145
BACKGROUND: Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic cancer. ...METHODS: Pancreatic cancer cells expressing IGF1R shRNA were established, and the cell proliferation, colony forma …
BACKGROUND: Insulin-like growth factor 1 receptor (IGF1R) plays important roles in the progression of pancreatic can …
mTOR inhibition induces EGFR feedback activation in association with its resistance to human pancreatic cancer.
Wei F, Zhang Y, Geng L, Zhang P, Wang G, Liu Y. Wei F, et al. Int J Mol Sci. 2015 Feb 3;16(2):3267-82. doi: 10.3390/ijms16023267. Int J Mol Sci. 2015. PMID: 25654224 Free PMC article.
Additionally, we found that AZD8055-induced transient AKT inhibition increased the expression and activation of epidermal growth factor receptor (EGFR) by releasing its transcriptional factors Fork-head box O 1/3a (FoxO1/3a), which might contribute to cell resistance to AZD8055. …
Additionally, we found that AZD8055-induced transient AKT inhibition increased the expression and activation of epidermal growth factor rece …
Genetic blockade of the insulin-like growth factor 1 receptor for human malignancy.
Adachi Y, Lee CT, Carbone DP. Adachi Y, et al. Novartis Found Symp. 2004;262:177-89; discussion 190-2, 265-8. Novartis Found Symp. 2004. PMID: 15562829 Review.
Growth factor receptor signals, including insulin-like growth factor (IGF)-1 receptor (IGF-1R), are required for carcinogenesis and tumour progression in many human malignancies. ...IGF-1R/482st was more effective than IGF-IR/950st due to its bystander …
Growth factor receptor signals, including insulin-like growth factor (IGF)-1 receptor (IGF-1R), are required for carcinogenesis and t …
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.
Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W. Hernandez R, et al. Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17. Diabetes. 2017. PMID: 28515126 Free PMC article.
The noninvasive measurement of functional beta-cell mass would be clinically valuable for monitoring the progression of type 1 and type 2 diabetes as well as the viability of transplanted insulin-producing cells. ...In a mouse model of streptozotocin-induced …
The noninvasive measurement of functional beta-cell mass would be clinically valuable for monitoring the progression of type 1 and ty …
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.
Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM. Brereton MF, et al. Nat Commun. 2016 Nov 24;7:13496. doi: 10.1038/ncomms13496. Nat Commun. 2016. PMID: 27882918 Free PMC article.
Insulin secretion from pancreatic beta-cells is impaired in all forms of diabetes. ...Sulphonylurea therapy rapidly normalizes blood glucose levels, dissipates glycogen stores, increases autophagy and restores beta-cell metabolism. Insulin therapy has the sam …
Insulin secretion from pancreatic beta-cells is impaired in all forms of diabetes. ...Sulphonylurea therapy rapidly normalizes …
20 results