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In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW. Sasner M, et al. bioRxiv [Preprint]. 2023 Dec 24:2023.12.21.572849. doi: 10.1101/2023.12.21.572849. bioRxiv. 2023. Update in: Alzheimers Dement. 2024 Jul;20(7):4970-4984. doi: 10.1002/alz.13840. PMID: 38187758 Free PMC article. Updated. Preprint.
INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer's disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease …
INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with lat …
In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Sasner M, Preuss C, Pandey RS, Uyar A, Garceau D, Kotredes KP, Williams H, Oblak AL, Lin PB, Perkins B, Soni D, Ingraham C, Lee-Gosselin A, Lamb BT, Howell GR, Carter GW. Sasner M, et al. Alzheimers Dement. 2024 Jul;20(7):4970-4984. doi: 10.1002/alz.13840. Epub 2024 Apr 30. Alzheimers Dement. 2024. PMID: 38687251 Free PMC article.
INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with late-onset Alzheimer's disease (LOAD), but few candidate polymorphisms have been functionally assessed for disease …
INTRODUCTION: Genome-wide association studies have identified over 70 genetic loci associated with lat …
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA; Alzheimer Disease Genetics Consortium; Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha… See abstract for full author list ➔ Naj AC, et al. JAMA Neurol. 2014 Nov;71(11):1394-404. doi: 10.1001/jamaneurol.2014.1491. JAMA Neurol. 2014. PMID: 25199842 Free PMC article.
IMPORTANCE: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in …
IMPORTANCE: Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differe …
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.
Manzoni C, Kia DA, Ferrari R, Leonenko G, Costa B, Saba V, Jabbari E, Tan MM, Albani D, Alvarez V, Alvarez I, Andreassen OA, Angiolillo A, Arighi A, Baker M, Benussi L, Bessi V, Binetti G, Blackburn DJ, Boada M, Boeve BF, Borrego-Ecija S, Borroni B, Bråthen G, Brooks WS, Bruni AC, Caroppo P, Bandres-Ciga S, Clarimon J, Colao R, Cruchaga C, Danek A, de Boer SC, de Rojas I, di Costanzo A, Dickson DW, Diehl-Schmid J, Dobson-Stone C, Dols-Icardo O, Donizetti A, Dopper E, Durante E, Ferrari C, Forloni G, Frangipane F, Fratiglioni L, Kramberger MG, Galimberti D, Gallucci M, García-González P, Ghidoni R, Giaccone G, Graff C, Graff-Radford NR, Grafman J, Halliday GM, Hernandez DG, Hjermind LE, Hodges JR, Holloway G, Huey ED, Illán-Gala I, Josephs KA, Knopman DS, Kristiansen M, Kwok JB, Leber I, Leonard HL, Libri I, Lleo A, Mackenzie IR, Madhan GK, Maletta R, Marquié M, Maver A, Menendez-Gonzalez M, Milan G, Miller BL, Morris CM, Morris HR, Nacmias B, Newton J, Nielsen JE, Nilsson C, Novelli V, Padovani A, Pal S, Pasquier F, Pastor P, Perneczky R, Peterlin B, Petersen RC, Piguet O, Pijnenburg YA, Puca AA, Rademakers R, Rainero I, Reus LM, Richardson AM, Riemenschneider M, Rogaeva E, Rogelj… See abstract for full author list ➔ Manzoni C, et al. Am J Hum Genet. 2024 Jul 11;111(7):1316-1329. doi: 10.1016/j.ajhg.2024.05.017. Epub 2024 Jun 17. Am J Hum Genet. 2024. PMID: 38889728 Free PMC article.
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sF …
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Eff …
Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease.
Tosto G, Vardarajan B, Sariya S, Brickman AM, Andrews H, Manly JJ, Schupf N, Reyes-Dumeyer D, Lantigua R, Bennett DA, De Jager PL, Mayeux R. Tosto G, et al. JAMA Neurol. 2019 Aug 1;76(8):942-948. doi: 10.1001/jamaneurol.2019.1066. JAMA Neurol. 2019. PMID: 31058951 Free PMC article.
IMPORTANCE: Genetic causes of late-onset Alzheimer disease (LOAD) are not completely explained by known genetic loci. ...MAIN OUTCOMES AND MEASURES: Late-onset Alzheimer disease. RESULTS: The discovery c …
IMPORTANCE: Genetic causes of late-onset Alzheimer disease (LOAD) are not completely explained by known …
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk.
Novikova G, Andrews SJ, Renton AE, Marcora E. Novikova G, et al. Mol Neurodegener. 2021 Apr 21;16(1):27. doi: 10.1186/s13024-021-00449-0. Mol Neurodegener. 2021. PMID: 33882988 Free PMC article. Review.
Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease-modifying treatments are currently available. Genome-wide association studies (GWASs) have identified more than 40 …
Alzheimer's disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease …
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.
Davies G, Harris SE, Reynolds CA, Payton A, Knight HM, Liewald DC, Lopez LM, Luciano M, Gow AJ, Corley J, Henderson R, Murray C, Pattie A, Fox HC, Redmond P, Lutz MW, Chiba-Falek O, Linnertz C, Saith S, Haggarty P, McNeill G, Ke X, Ollier W, Horan M, Roses AD, Ponting CP, Porteous DJ, Tenesa A, Pickles A, Starr JM, Whalley LJ, Pedersen NL, Pendleton N, Visscher PM, Deary IJ. Davies G, et al. Mol Psychiatry. 2014 Jan;19(1):76-87. doi: 10.1038/mp.2012.159. Epub 2012 Dec 4. Mol Psychiatry. 2014. PMID: 23207651 Free PMC article.
We undertook a genome-wide association analysis using 549 692 single-nucleotide polymorphisms (SNPs) in 3511 unrelated adults in the Cognitive Ageing Genetics in England and Scotland (CAGES) project. ...One SNP--rs2075650, located in TOMM40 (translocase of th …
We undertook a genome-wide association analysis using 549 692 single-nucleotide polymorphisms (SNPs) in 3511 unrelated …
Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loci, along with evidence of both genetic and sample heterogeneity.
Choi Y, Marchani EE, Bird TD, Steinbart EJ, Blacker D, Wijsman EM. Choi Y, et al. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):785-98. doi: 10.1002/ajmg.b.31220. Epub 2011 Aug 2. Am J Med Genet B Neuropsychiatr Genet. 2011. PMID: 21812099 Free PMC article.
Alzheimer's disease (AD) is a common neurodegenerative disorder of late life with a complex genetic basis. ...APOE genotypes vary in their AD risk as well as age-at-onset distributions, and it is likely that other loci will …
Alzheimer's disease (AD) is a common neurodegenerative disorder of late life with a complex genetic basis. ...AP …
Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.
Raj T, Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, Stranger BE, De Jager PL. Raj T, et al. Am J Hum Genet. 2012 Apr 6;90(4):720-6. doi: 10.1016/j.ajhg.2012.02.022. Am J Hum Genet. 2012. PMID: 22482808 Free PMC article.
Recent genome-wide association studies have identified a number of susceptibility loci for Alzheimer disease (AD). ...This observation may be AD-specific, as the 12 loci associated with Parkinson disease do not demonstrate e …
Recent genome-wide association studies have identified a number of susceptibility loci for Alzheimer d …
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans.
Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R; Alzheimer Disease Genetics Consortium. Reitz C, et al. JAMA. 2013 Apr 10;309(14):1483-92. doi: 10.1001/jama.2013.2973. JAMA. 2013. PMID: 23571587 Free PMC article.
IMPORTANCE: Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for individuals of European ancestry, but whether the same or different variants account for the genetic risk of Alzheimer dis …
IMPORTANCE: Genetic variants associated with susceptibility to late-onset Alzheimer disease are known for …
12 results