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Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system.
Guo R, Wan Y, Xu D, Cui L, Deng M, Zhang G, Jia R, Zhou W, Wang Z, Deng K, Huang M, Wang F, Zhang Y. Guo R, et al. Sci Rep. 2016 Jul 15;6:29855. doi: 10.1038/srep29855. Sci Rep. 2016. PMID: 27417210 Free PMC article.
Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. ...In conclusion, we efficiently generated Mstn KO rabbits and goats using CRISPR/Cas9 technology. ...
Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. ...In conclusion, we efficiently gen
Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes.
Crispo M, Mulet AP, Tesson L, Barrera N, Cuadro F, dos Santos-Neto PC, Nguyen TH, Crénéguy A, Brusselle L, Anegón I, Menchaca A. Crispo M, et al. PLoS One. 2015 Aug 25;10(8):e0136690. doi: 10.1371/journal.pone.0136690. eCollection 2015. PLoS One. 2015. PMID: 26305800 Free PMC article.
Myostatin is encoded by MSTN gene involved in the inhibition of muscle differentiation and growth. We determined the efficiency of the CRISPR/Cas9 system to edit MSTN in sheep and generate knock-out (KO) animals with the aim to promote muscle developme
Myostatin is encoded by MSTN gene involved in the inhibition of muscle differentiation and growth. We determined the efficiency
Generation of myostatin edited horse embryos using CRISPR/Cas9 technology and somatic cell nuclear transfer.
Moro LN, Viale DL, Bastón JI, Arnold V, Suvá M, Wiedenmann E, Olguín M, Miriuka S, Vichera G. Moro LN, et al. Sci Rep. 2020 Sep 24;10(1):15587. doi: 10.1038/s41598-020-72040-4. Sci Rep. 2020. PMID: 32973188 Free PMC article.
The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we aimed to knock out the myostatin gene (MSTN), a negative regulator of muscle mass development, using CRISPR/Cas9 and to gener
The application of new technologies for gene editing in horses may allow the generation of improved sportive individuals. Here, we ai …
Comparison of gene editing efficiencies of CRISPR/Cas9 and TALEN for generation of MSTN knock-out cashmere goats.
Zhang J, Liu J, Yang W, Cui M, Dai B, Dong Y, Yang J, Zhang X, Liu D, Liang H, Cang M. Zhang J, et al. Theriogenology. 2019 Jul 1;132:1-11. doi: 10.1016/j.theriogenology.2019.03.029. Epub 2019 Apr 1. Theriogenology. 2019. PMID: 30981084
Here, we compared CRISPR/Cas9 and TALEN technologies at multiple levels for generating a knock out (KO) of the Alpas cashmere goat myostatin (MSTN) gene, which negatively regulates the proliferation and differentiation of skeletal muscle cells. The electrotra …
Here, we compared CRISPR/Cas9 and TALEN technologies at multiple levels for generating a knock out (KO) of the Alpas cashmere …
CRISPR/Cas9-mediated MSTN disruption accelerates the growth of Chinese Bama pigs.
Zhu XX, Zhan QM, Wei YY, Yan AF, Feng J, Liu L, Lu SS, Tang DS. Zhu XX, et al. Reprod Domest Anim. 2020 Oct;55(10):1314-1327. doi: 10.1111/rda.13775. Epub 2020 Aug 14. Reprod Domest Anim. 2020. PMID: 32679613
CRISPR/Cas9-mediated genome editing technology is a simple and highly efficient and specific genome modification approach with wide applications in the animal industry. ...This study aimed to address the disadvantages of slow growth and low percentage of lean meat in Chine …
CRISPR/Cas9-mediated genome editing technology is a simple and highly efficient and specific genome modification approach with wide a …
A promoter trap vector for knocking out bovine myostatin gene with high targeting efficiency.
Zhao LH, Zhao YH, Liang H, Yun T, Han XJ, Zhang ML, Zhou X, Hou DX, Li RF, Li XL. Zhao LH, et al. Genet Mol Res. 2015 Mar 31;14(1):2750-61. doi: 10.4238/2015.March.31.5. Genet Mol Res. 2015. PMID: 25867424 Free article.
In this study, to knock out the bovine myostatin gene, we constructed a promoter trap vector and compared its efficiency with that of ZFNs. ...The targeted-positive cell clones were identified based on green fluorescence and G418 double selection, followed by …
In this study, to knock out the bovine myostatin gene, we constructed a promoter trap vector and compared its efficiency
Isozygous and selectable marker-free MSTN knockout cloned pigs generated by the combined use of CRISPR/Cas9 and Cre/LoxP.
Bi Y, Hua Z, Liu X, Hua W, Ren H, Xiao H, Zhang L, Li L, Wang Z, Laible G, Wang Y, Dong F, Zheng X. Bi Y, et al. Sci Rep. 2016 Aug 17;6:31729. doi: 10.1038/srep31729. Sci Rep. 2016. PMID: 27530319 Free PMC article.
Predictable, clean genetic modification (GM) in livestock is important for reliable phenotyping and biosafety. Here we reported the generation of isozygous, functional myostatin (MSTN) knockout cloned pigs free of selectable marker gene (SMG) by CRISPR/Cas9 and Cre/ …
Predictable, clean genetic modification (GM) in livestock is important for reliable phenotyping and biosafety. Here we reported the gener