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Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi.
Stoldt VR, Sonneborn A, Leuker CE, Ernst JF. Stoldt VR, et al. EMBO J. 1997 Apr 15;16(8):1982-91. doi: 10.1093/emboj/16.8.1982. EMBO J. 1997. PMID: 9155024 Free PMC article.
Overexpression of EFG1 in C. albicans leads to enhanced filamentous growth in the form of extended pseudohyphae in liquid and on solid media. The results suggest that Efg1p has a dual role as a transcriptional activator and repressor, whose balanced activity is essential f …
Overexpression of EFG1 in C. albicans leads to enhanced filamentous growth in the form of extended pseudohyphae in liquid and on solid media …
Functional mapping of the Candida albicans Efg1 regulator.
Noffz CS, Liedschulte V, Lengeler K, Ernst JF. Noffz CS, et al. Eukaryot Cell. 2008 May;7(5):881-93. doi: 10.1128/EC.00033-08. Epub 2008 Mar 28. Eukaryot Cell. 2008. PMID: 18375615 Free PMC article.
A systematic deletion approach to specify functional domains of Efg1p revealed that the APSES domain is essential for morphogenesis of the normal yeast and true hyphal cell forms and that bHLH flanking sequences are needed for Efg1p stability. ...Yeast two-hybrid ex …
A systematic deletion approach to specify functional domains of Efg1p revealed that the APSES domain is essential for morphogenesis o …
A role for Efg1p in Candida albicans interactions with extracellular matrices.
Saville SP, Thomas DP, López Ribot JL. Saville SP, et al. FEMS Microbiol Lett. 2006 Mar;256(1):151-8. doi: 10.1111/j.1574-6968.2006.00109.x. FEMS Microbiol Lett. 2006. PMID: 16487333
Candida albicans interactions with extracellular matrices extracellular matrices represent hallmarks of invasive candidiasis. We have assessed the role of Efg1p, a key transcriptional regulator, in the interactions between C. albicans and extracellular matrices. ...Results …
Candida albicans interactions with extracellular matrices extracellular matrices represent hallmarks of invasive candidiasis. We have assess …
Transcriptional response of Candida albicans to hypoxia: linkage of oxygen sensing and Efg1p-regulatory networks.
Setiadi ER, Doedt T, Cottier F, Noffz C, Ernst JF. Setiadi ER, et al. J Mol Biol. 2006 Aug 18;361(3):399-411. doi: 10.1016/j.jmb.2006.06.040. Epub 2006 Jul 7. J Mol Biol. 2006. PMID: 16854431
Instead, Efg1p was specifically required for hypoxic expression or repression of subsets of genes. One class of hypoxia-regulated genes, encoding proteins involved in fatty acid biosynthesis, was dependent on Efg1p for maximal hypoxic expression, requiring Efg1p
Instead, Efg1p was specifically required for hypoxic expression or repression of subsets of genes. One class of hypoxia-regulated gen …
Adaptation of the Efg1p morphogenetic pathway in Candida albicans by negative autoregulation and PKA-dependent repression of the EFG1 gene.
Tebarth B, Doedt T, Krishnamurthy S, Weide M, Monterola F, Dominguez A, Ernst JF. Tebarth B, et al. J Mol Biol. 2003 Jun 20;329(5):949-62. doi: 10.1016/s0022-2836(03)00505-9. J Mol Biol. 2003. PMID: 12798685
The Efg1p regulator protein permits hyphal morphogenesis in the human fungal pathogen Candida albicans. We have identified the major promoter of the EFG1 gene as a direct target of Efg1p, resulting in negative autoregulation of EFG1. Enhanced activity of protein kin …
The Efg1p regulator protein permits hyphal morphogenesis in the human fungal pathogen Candida albicans. We have identified the major …
Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression.
Giusani AD, Vinces M, Kumamoto CA. Giusani AD, et al. Genetics. 2002 Apr;160(4):1749-53. doi: 10.1093/genetics/160.4.1749. Genetics. 2002. PMID: 11973327 Free PMC article.
Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation …
Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamen …
Normal adaptation of Candida albicans to the murine gastrointestinal tract requires Efg1p-dependent regulation of metabolic and host defense genes.
Pierce JV, Dignard D, Whiteway M, Kumamoto CA. Pierce JV, et al. Eukaryot Cell. 2013 Jan;12(1):37-49. doi: 10.1128/EC.00236-12. Epub 2012 Nov 2. Eukaryot Cell. 2013. PMID: 23125349 Free PMC article.
The goals of this study were to identify the Efg1p regulon during GI tract colonization and to compare C. albicans gene expression during colonization of different organs of the GI tract. ...Altered gene expression and altered growth capability support the ability of efg1( …
The goals of this study were to identify the Efg1p regulon during GI tract colonization and to compare C. albicans gene expression du …
Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator.
Sonneborn A, Bockmühl DP, Ernst JF. Sonneborn A, et al. Infect Immun. 1999 Oct;67(10):5514-7. doi: 10.1128/IAI.67.10.5514-5517.1999. Infect Immun. 1999. PMID: 10496941 Free PMC article.
Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamentation pathway in C. albicans....
Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamen …
Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection.
Staib P, Kretschmar M, Nichterlein T, Hof H, Morschhäuser J. Staib P, et al. Infect Immun. 2002 Feb;70(2):921-7. doi: 10.1128/IAI.70.2.921-927.2002. Infect Immun. 2002. PMID: 11796627 Free PMC article.
Using an in vivo expression technology that is based on genetic recombination as a reporter of gene activation during experimental candidiasis in mice, we investigated whether two signal transduction pathways controlling hyphal growth, a mitogen-activated protein kinase cascade e …
Using an in vivo expression technology that is based on genetic recombination as a reporter of gene activation during experimental candidias …
Expression of the Candida albicans morphogenesis regulator gene CZF1 and its regulation by Efg1p and Czf1p.
Vinces MD, Haas C, Kumamoto CA. Vinces MD, et al. Eukaryot Cell. 2006 May;5(5):825-35. doi: 10.1128/EC.5.5.825-835.2006. Eukaryot Cell. 2006. PMID: 16682460 Free PMC article.
Overexpression of CZF1 revealed that this gene also autoregulates its expression. Efg1p and Czf1p were shown by chromatin immunoprecipitation to act by binding to the promoter of CZF1. ...
Overexpression of CZF1 revealed that this gene also autoregulates its expression. Efg1p and Czf1p were shown by chromatin immunopreci …
64 results