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Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Jensen AA, Christesen T, Bølcho U, Greenwood JR, Postorino G, Vogensen SB, Johansen TN, Egebjerg J, Bräuner-Osborne H, Clausen RP. Jensen AA, et al. Among authors: egebjerg j. J Med Chem. 2007 Aug 23;50(17):4177-85. doi: 10.1021/jm070532r. Epub 2007 Aug 2. J Med Chem. 2007. PMID: 17672447
A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.
Christiansen GB, Harbak B, Hede SE, Gouliaev AH, Olsen L, Frydenvang K, Egebjerg J, Kastrup JS, Holm MM. Christiansen GB, et al. Among authors: egebjerg j. Neuroscience. 2015 Dec 3;310:709-22. doi: 10.1016/j.neuroscience.2015.09.073. Epub 2015 Oct 9. Neuroscience. 2015. PMID: 26450748
The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, Biilmann Rønn LC, de Jong IE, Malik IJ, Karlsson JJ, Bundgaard C, Egebjerg J, Stavenhagen JB, Strandbygård D, Thirup S, Andersen JL, Uppalanchi S, Pervaram S, Kasturi SP, Eradi P, Sakumudi DR, Watson SP. Schrøder TJ, et al. Among authors: egebjerg j. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. doi: 10.1016/j.bmcl.2013.11.046. Epub 2013 Nov 27. Bioorg Med Chem Lett. 2014. PMID: 24355129
Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.
Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS. Andersen J, et al. Among authors: egebjerg j. J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12. J Biol Chem. 2009. PMID: 19213730 Free PMC article.
Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis.
Hansen KB, Clausen RP, Bjerrum EJ, Bechmann C, Greenwood JR, Christensen C, Kristensen JL, Egebjerg J, Bräuner-Osborne H. Hansen KB, et al. Among authors: egebjerg j. Mol Pharmacol. 2005 Dec;68(6):1510-23. doi: 10.1124/mol.105.014795. Epub 2005 Aug 30. Mol Pharmacol. 2005. PMID: 16131614
Design, synthesis, and pharmacological characterization of polyamine toxin derivatives: potent ligands for the pore-forming region of AMPA receptors.
Jensen LS, Bølcho U, Egebjerg J, Strømgaard K. Jensen LS, et al. Among authors: egebjerg j. ChemMedChem. 2006 Apr;1(4):419-28. doi: 10.1002/cmdc.200500093. ChemMedChem. 2006. PMID: 16892377
Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.
Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS. Andersen J, et al. Among authors: egebjerg j. J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5. J Biol Chem. 2010. PMID: 19892699 Free PMC article.
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.
Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. Naur P, et al. Among authors: egebjerg j. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14116-21. doi: 10.1073/pnas.0703718104. Epub 2007 Aug 21. Proc Natl Acad Sci U S A. 2007. PMID: 17715062 Free PMC article.
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
Clausen RP, Hansen KB, Calí P, Nielsen B, Greenwood JR, Begtrup M, Egebjerg J, Bräuner-Osborne H. Clausen RP, et al. Among authors: egebjerg j. Eur J Pharmacol. 2004 Sep 19;499(1-2):35-44. doi: 10.1016/j.ejphar.2004.07.049. Eur J Pharmacol. 2004. PMID: 15363949
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C. Conti P, et al. Among authors: egebjerg j. J Med Chem. 2005 Oct 6;48(20):6315-25. doi: 10.1021/jm0504499. J Med Chem. 2005. PMID: 16190758
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