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Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.
Kilsgård O, Andersson P, Malmsten M, Nordin SL, Linge HM, Eliasson M, Sörenson E, Erjefält JS, Bylund J, Olin AI, Sørensen OE, Egesten A. Kilsgård O, et al. Among authors: egesten a. Am J Respir Cell Mol Biol. 2012 Feb;46(2):240-8. doi: 10.1165/rcmb.2010-0500OC. Epub 2011 Sep 29. Am J Respir Cell Mol Biol. 2012. PMID: 21960546
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