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MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
Takashina K, Bessho T, Mori R, Eguchi J, Saito K. Takashina K, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1027-35. doi: 10.1007/s00702-008-0048-1. Epub 2008 Apr 30. J Neural Transm (Vienna). 2008. PMID: 18446264
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Kohara T, Nakayama K, Watanabe K, Kusaka SI, Sakai D, Tanaka H, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Mori A, Tanaka S, Bessho T, Takiguchi-Hayashi K, Horikawa T. Kohara T, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3733-3738. doi: 10.1016/j.bmcl.2017.06.077. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712706
Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats.
Eguchi J, Iwai K, Yuasa T, Egawa M, Komatsu T, Saito K. Eguchi J, et al. Pharmacol Biochem Behav. 1995 Aug;51(4):935-9. doi: 10.1016/0091-3057(95)00087-d. Pharmacol Biochem Behav. 1995. PMID: 7675880
MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.
Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. Takashina K, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1037-46. doi: 10.1007/s00702-008-0049-0. Epub 2008 May 7. J Neural Transm (Vienna). 2008. PMID: 18461273
MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. Bessho T, et al. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. doi: 10.1007/s00702-008-0053-4. Epub 2008 May 7. J Neural Transm (Vienna). 2008. PMID: 18461272
Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors.
Usui Y, Uehara F, Hiki S, Watanabe K, Tanaka H, Shouda A, Yokoshima S, Aritomo K, Adachi T, Fukunaga K, Sunada S, Nabeno M, Saito KI, Eguchi JI, Yamagami K, Asano S, Tanaka S, Yuki S, Yoshii N, Fujimura M, Horikawa T. Usui Y, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3726-3732. doi: 10.1016/j.bmcl.2017.06.078. Epub 2017 Jul 5. Bioorg Med Chem Lett. 2017. PMID: 28712708
Effects of a novel compound MCI-225 on impaired learning and memory in rats.
Eguchi J, Yuasa T, Egawa M, Tobe A. Eguchi J, et al. Pharmacol Biochem Behav. 1994 Jun;48(2):345-9. doi: 10.1016/0091-3057(94)90536-3. Pharmacol Biochem Behav. 1994. PMID: 8090800
Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats.
Teshima K, Minoguchi M, Tounai S, Ashimori A, Eguchi J, Allen CN, Shibata S. Teshima K, et al. Br J Pharmacol. 2005 Sep;146(1):33-40. doi: 10.1038/sj.bjp.0706311. Br J Pharmacol. 2005. PMID: 15980870 Free PMC article.
These suppressive effects were blocked by an ORL1 receptor antagonist, J-113397 (1 microM). W-212393 (3 mg kg(-1), i.p.) induced a significant phase advance at circadian time 6 (CT6) and CT9, but not at other CTs. ...-induced phase advance was antagonized by J-11339 …
These suppressive effects were blocked by an ORL1 receptor antagonist, J-113397 (1 microM). W-212393 (3 mg kg(-1), i.p.) induced a si …
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