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Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer's disease.
Fukunaga K, Sakai D, Watanabe K, Nakayama K, Kohara T, Tanaka H, Sunada S, Nabeno M, Okamoto M, Saito K, Eguchi J, Mori A, Tanaka S, Inazawa K, Horikawa T. Fukunaga K, et al. Among authors: eguchi j. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1086-91. doi: 10.1016/j.bmcl.2015.01.005. Epub 2015 Jan 13. Bioorg Med Chem Lett. 2015. PMID: 25655721
2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors.
Fukunaga K, Uehara F, Aritomo K, Shoda A, Hiki S, Okuyama M, Usui Y, Watanabe K, Yamakoshi K, Kohara T, Hanano T, Tanaka H, Tsuchiya S, Sunada S, Saito K, Eguchi J, Yuki S, Asano S, Tanaka S, Mori A, Yamagami K, Baba H, Horikawa T, Fujimura M. Fukunaga K, et al. Among authors: eguchi j. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7. doi: 10.1016/j.bmcl.2013.09.020. Epub 2013 Sep 21. Bioorg Med Chem Lett. 2013. PMID: 24176395
158 results