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The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors.
Eguren M, Porlan E, Manchado E, García-Higuera I, Cañamero M, Fariñas I, Malumbres M. Eguren M, et al. Nat Commun. 2013;4:2880. doi: 10.1038/ncomms3880. Nat Commun. 2013. PMID: 24301385 Free article.
An actin-dependent spindle position checkpoint ensures the asymmetric division in mouse oocytes.
Metchat A, Eguren M, Hossain JM, Politi AZ, Huet S, Ellenberg J. Metchat A, et al. Among authors: eguren m. Nat Commun. 2015 Jul 15;6:7784. doi: 10.1038/ncomms8784. Nat Commun. 2015. PMID: 26174204 Free PMC article. Retracted.
A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.
Eguren M, Álvarez-Fernández M, García F, López-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernández-Capetillo O, Muñoz J, Yamano H, Malumbres M. Eguren M, et al. Cell Rep. 2014 Feb 27;6(4):670-83. doi: 10.1016/j.celrep.2014.01.017. Epub 2014 Feb 6. Cell Rep. 2014. PMID: 24508461 Free article.
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.
Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Wan L, et al. Among authors: eguren m. Mol Cell. 2011 Dec 9;44(5):721-33. doi: 10.1016/j.molcel.2011.09.024. Mol Cell. 2011. PMID: 22152476 Free PMC article.
Non-mitotic functions of the Anaphase-Promoting Complex.
Eguren M, Manchado E, Malumbres M. Eguren M, et al. Semin Cell Dev Biol. 2011 Aug;22(6):572-8. doi: 10.1016/j.semcdb.2011.03.010. Epub 2011 Mar 23. Semin Cell Dev Biol. 2011. PMID: 21439391 Review.
The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions.
Manchado E, Eguren M, Malumbres M. Manchado E, et al. Among authors: eguren m. Biochem Soc Trans. 2010 Feb;38(Pt 1):65-71. doi: 10.1042/BST0380065. Biochem Soc Trans. 2010. PMID: 20074037 Review.
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Manchado E, Guillamot M, de Cárcer G, Eguren M, Trickey M, García-Higuera I, Moreno S, Yamano H, Cañamero M, Malumbres M. Manchado E, et al. Among authors: eguren m. Cancer Cell. 2010 Dec 14;18(6):641-54. doi: 10.1016/j.ccr.2010.10.028. Cancer Cell. 2010. PMID: 21156286
APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.
Rattani A, Ballesteros Mejia R, Roberts K, Roig MB, Godwin J, Hopkins M, Eguren M, Sanchez-Pulido L, Okaz E, Ogushi S, Wolna M, Metson J, Pendás AM, Malumbres M, Novák B, Herbert M, Nasmyth K. Rattani A, et al. Among authors: eguren m. Curr Biol. 2017 May 22;27(10):1462-1476.e5. doi: 10.1016/j.cub.2017.04.023. Epub 2017 May 11. Curr Biol. 2017. PMID: 28502659 Free PMC article.
Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M. Rodríguez-Díez E, et al. Among authors: eguren m. Blood. 2014 Oct 9;124(15):2380-90. doi: 10.1182/blood-2014-02-555292. Epub 2014 Aug 25. Blood. 2014. PMID: 25157181
Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.
Búa S, Sotiropoulou P, Sgarlata C, Borlado LR, Eguren M, Domínguez O, Ortega S, Malumbres M, Blanpain C, Méndez J. Búa S, et al. Among authors: eguren m. Cell Cycle. 2015;14(24):3897-907. doi: 10.1080/15384101.2015.1120919. Cell Cycle. 2015. PMID: 26697840 Free PMC article.
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