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Page 1
Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine.
Nijs J, George SZ, Clauw DJ, Fernández-de-Las-Peñas C, Kosek E, Ickmans K, Fernández-Carnero J, Polli A, Kapreli E, Huysmans E, Cuesta-Vargas AI, Mani R, Lundberg M, Leysen L, Rice D, Sterling M, Curatolo M. Nijs J, et al. Lancet Rheumatol. 2021 May;3(5):e383-e392. doi: 10.1016/S2665-9913(21)00032-1. Epub 2021 Mar 30. Lancet Rheumatol. 2021. PMID: 38279393 Review.
Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including fibromyalgia, osteoarthritis, rheumatoid arthritis, Ehlers-Danlos syndrome, upper extremity tendinopathies, headache, and spina …
Features of central sensitisation have been documented in various pain conditions common in rheumatology practice, including f …
Central sensitization in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome-a feasibility study.
Schubert-Hjalmarsson E, Fasth A, Ickmans K, Mårdbrink EL, Söderpalm AC, Lundberg M. Schubert-Hjalmarsson E, et al. Pilot Feasibility Stud. 2023 Jun 14;9(1):97. doi: 10.1186/s40814-023-01320-3. Pilot Feasibility Stud. 2023. PMID: 37316864 Free PMC article.
BACKGROUND: Pain is a major symptom in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. Although the underlying mechanism causing generalized pain in children with hypermobility spectrum disorder or hypermobile Ehlers- …
BACKGROUND: Pain is a major symptom in adolescents with hypermobility spectrum disorder or hypermobile Ehlers-Danlos syndrome. …
Exploring signs of central sensitization in adolescents with hypermobility Spectrum disorder or hypermobile Ehlers-Danlos syndrome.
Schubert-Hjalmarsson E, Fasth A, Ickmans K, Söderpalm AC, Lundberg M. Schubert-Hjalmarsson E, et al. Eur J Pain. 2025 Jan;29(1):e4754. doi: 10.1002/ejp.4754. Epub 2024 Nov 11. Eur J Pain. 2025. PMID: 39529262 Free PMC article.
Central sensitization has been proposed as a plausible explanation for symptoms like widespread pain, fatigue, mood disorders, and sleep disturbances in patients with HSD/hEDS. ...Pain should be considered as a phenomenon that is influenced by different biopsychosoc …
Central sensitization has been proposed as a plausible explanation for symptoms like widespread pain, fatigue, mood disorders, …
Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type.
Di Stefano G, Celletti C, Baron R, Castori M, Di Franco M, La Cesa S, Leone C, Pepe A, Cruccu G, Truini A, Camerota F. Di Stefano G, et al. Eur J Pain. 2016 Sep;20(8):1319-25. doi: 10.1002/ejp.856. Epub 2016 Feb 26. Eur J Pain. 2016. PMID: 26919608
CONCLUSIONS: While the lack of somatosensory nervous system damage is incompatible with neuropathic pain as the mechanism underlying pain in JHS/EDS-HT, the lowered cold and heat pain thresholds and increased wind-up ratio imply that pain in JHS/EDS-HT might arise t …
CONCLUSIONS: While the lack of somatosensory nervous system damage is incompatible with neuropathic pain as the mechanism unde …
Hypermobility, the Ehlers-Danlos syndromes and chronic pain.
Syx D, De Wandele I, Rombaut L, Malfait F. Syx D, et al. Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 107(5):116-122. Epub 2017 Sep 28. Clin Exp Rheumatol. 2017. PMID: 28967365 Free article. Review.
Clinical overlap of JHS is seen with heritable connective tissue disorders, particularly with the Ehlers-Danlos syndrome, hypermobile type (hEDS). The Ehlers-Danlos syndromes (EDS) comprise a heterogeneous group of rare monogenic conditions that are ch …
Clinical overlap of JHS is seen with heritable connective tissue disorders, particularly with the Ehlers-Danlos syndrome, hype …
Temporal model for central sensitization: A hypothesis for mechanism and treatment using systemic manual therapy, a focused review.
Halili A. Halili A. MethodsX. 2022 Nov 28;10:101942. doi: 10.1016/j.mex.2022.101942. eCollection 2023. MethodsX. 2022. PMID: 36570602 Free PMC article. Review.
The key to understanding central sensitization is a firm grasp on structure and function of the Locus-coeruleus noradrenaline system (LC-NA). ...This review evaluates the mechanisms and temporal relationships behind four components: salient stimuli, threat co …
The key to understanding central sensitization is a firm grasp on structure and function of the Locus-coeruleus noradrenaline …
Connective tissue, Ehlers-Danlos syndrome(s), and head and cervical pain.
Castori M, Morlino S, Ghibellini G, Celletti C, Camerota F, Grammatico P. Castori M, et al. Am J Med Genet C Semin Med Genet. 2015 Mar;169C(1):84-96. doi: 10.1002/ajmg.c.31426. Epub 2015 Feb 5. Am J Med Genet C Semin Med Genet. 2015. PMID: 25655119 Review.
Ehlers-Danlos syndrome (EDS) is an umbrella term for a growing group of hereditary disorders of the connective tissue mainly manifesting with generalized joint hypermobility, skin hyperextensibility, and vascular and internal organ fragility. ...The underlying patho …
Ehlers-Danlos syndrome (EDS) is an umbrella term for a growing group of hereditary disorders of the connective tissue mainly m …
Pain in hypermobile Ehlers-Danlos syndrome: New insights using new criteria.
Bénistan K, Martinez V. Bénistan K, et al. Am J Med Genet A. 2019 Jul;179(7):1226-1234. doi: 10.1002/ajmg.a.61175. Epub 2019 May 10. Am J Med Genet A. 2019. PMID: 31075184
Features of the pain in hypermobile Ehlers-Danlos syndrome (hEDS) are complex and insufficiently known by clinicians. We enrolled 37 hEDS patients. ...Peripheral neuropathic pain is frequent and central sensitization appears to be a key step in the evo …
Features of the pain in hypermobile Ehlers-Danlos syndrome (hEDS) are complex and insufficiently known by clinicians. We enrol …
A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers-Danlos Syndrome.
Basem JI, Lin T, Mehta ND. Basem JI, et al. Curr Pain Headache Rep. 2022 Dec;26(12):871-876. doi: 10.1007/s11916-022-01093-z. Epub 2022 Nov 25. Curr Pain Headache Rep. 2022. PMID: 36434419 Review.
PURPOSE OF REVIEW: Patients diagnosed with Ehlers-Danlos syndromes (EDS), and especially those with the hypermobility subtype, often experience a diverse range of acute and chronic pain conditions throughout their lifetime. ...Most research also emphasizes that pain …
PURPOSE OF REVIEW: Patients diagnosed with Ehlers-Danlos syndromes (EDS), and especially those with the hypermobility subtype, …
Evidence for central sensitization as classified by the central sensitization inventory in patients with pain and hypermobility.
Desai MJ, Brestle M, Jonely H. Desai MJ, et al. Pain Pract. 2025 Jan;25(1):e13411. doi: 10.1111/papr.13411. Epub 2024 Aug 27. Pain Pract. 2025. PMID: 39192465
Central sensitization (CS) has been postulated as a potential etiological factor. METHODS: In this retrospective study, 82 consecutive patients with hEDS/HSDs were reviewed. Demographic information and Central Sensitization Inventory (CSI) results were …
Central sensitization (CS) has been postulated as a potential etiological factor. METHODS: In this retrospective study, 82 con …
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