Eigenbrot C - Search Results

1

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: eigenbrot c. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

2

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments.

Kelley RF, O'Connell MP, Carter P, Presta L, Eigenbrot C, Covarrubias M, Snedecor B, Bourell JH, Vetterlein D. Kelley RF, et al. Among authors: eigenbrot c. Biochemistry. 1992 Jun 23;31(24):5434-41. doi: 10.1021/bi00139a003. Biochemistry. 1992. PMID: 1351741

3

The tissue factor region that interacts with substrates factor IX and Factor X.

Kirchhofer D, Lipari MT, Moran P, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Biochemistry. 2000 Jun 27;39(25):7380-7. doi: 10.1021/bi000182+. Biochemistry. 2000. PMID: 10858285

4

Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies.

Kirchhofer D, Moran P, Chiang N, Kim J, Riederer MA, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Thromb Haemost. 2000 Dec;84(6):1072-81. Thromb Haemost. 2000. PMID: 11154116

5

The tissue factor region that interacts with factor Xa in the activation of factor VII.

Kirchhofer D, Eigenbrot C, Lipari MT, Moran P, Peek M, Kelley RF. Kirchhofer D, et al. Among authors: eigenbrot c. Biochemistry. 2001 Jan 23;40(3):675-82. doi: 10.1021/bi002013v. Biochemistry. 2001. PMID: 11170384

6

Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.

Eigenbrot C, Meng YG, Krishnamurthy R, Lipari MT, Presta L, Devaux B, Wong T, Moran P, Bullens S, Kirchhofer D. Eigenbrot C, et al. J Mol Biol. 2003 Aug 8;331(2):433-46. doi: 10.1016/s0022-2836(03)00735-6. J Mol Biol. 2003. PMID: 12888350

7

Kelley RF, Yang J, Eigenbrot C, Moran P, Peek M, Lipari MT, Kirchhofer D. Kelley RF, et al. Among authors: eigenbrot c. Biochemistry. 2004 Feb 10;43(5):1223-9. doi: 10.1021/bi035738i. Biochemistry. 2004. PMID: 14756558

Although a structure is not available for the TF-VII complex, the structure determined for free VII [Eigenbrot, C., et al. (2001) Structure 9, 675-682] suggests a significant conformational change for the zymogen to enzyme transition. ...

Although a structure is not available for the TF-VII complex, the structure determined for free VII [Eigenbrot, C., et al. (20 …

8

Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.

Sidhu SS, Li B, Chen Y, Fellouse FA, Eigenbrot C, Fuh G. Sidhu SS, et al. Among authors: eigenbrot c. J Mol Biol. 2004 Apr 23;338(2):299-310. doi: 10.1016/j.jmb.2004.02.050. J Mol Biol. 2004. PMID: 15066433

9

Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody.

Zhang B, Yang Y, Yuk I, Pai R, McKay P, Eigenbrot C, Dennis M, Katta V, Francissen KC. Zhang B, et al. Among authors: eigenbrot c. Anal Chem. 2008 Apr 1;80(7):2379-90. doi: 10.1021/ac701810q. Epub 2008 Feb 29. Anal Chem. 2008. PMID: 18307322

10

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.

Brightbill HD, Jeet S, Lin Z, Yan D, Zhou M, Tan M, Nguyen A, Yeh S, Delarosa D, Leong SR, Wong T, Chen Y, Ultsch M, Luis E, Ramani SR, Jackman J, Gonzalez L, Dennis MS, Chuntharapai A, DeForge L, Meng YG, Xu M, Eigenbrot C, Lee WP, Refino CJ, Balazs M, Wu LC. Brightbill HD, et al. Among authors: eigenbrot c. J Clin Invest. 2010 Jun;120(6):2218-29. doi: 10.1172/JCI40141. Epub 2010 May 10. J Clin Invest. 2010. PMID: 20458139 Free PMC article.

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