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The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.
Kelly SL, Lamb DC, Loeffler J, Einsele H, Kelly DE. Kelly SL, et al. Biochem Biophys Res Commun. 1999 Aug 19;262(1):174-9. doi: 10.1006/bbrc.1999.1136. Biochem Biophys Res Commun. 1999. PMID: 10448088
Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains.
Löffler J, Kelly SL, Hebart H, Schumacher U, Lass-Flörl C, Einsele H. Löffler J, et al. FEMS Microbiol Lett. 1997 Jun 15;151(2):263-8. doi: 10.1111/j.1574-6968.1997.tb12580.x. FEMS Microbiol Lett. 1997. PMID: 9228762
Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients.
Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Kelly SL, et al. Lancet. 1996 Nov 30;348(9040):1523-4. doi: 10.1016/S0140-6736(05)65949-1. Lancet. 1996. PMID: 8942815 No abstract available.
Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation.
Kelly SL, Lamb DC, Kelly DE, Manning NJ, Loeffler J, Hebart H, Schumacher U, Einsele H. Kelly SL, et al. FEBS Lett. 1997 Jan 2;400(1):80-2. doi: 10.1016/s0014-5793(96)01360-9. FEBS Lett. 1997. PMID: 9000517
Infectious pulmonary complications after stem cell transplantation or chemotherapy: diagnostic yield of bronchoalveolar lavage.
Bissinger AL, Einsele H, Hamprecht K, Schumacher U, Kandolf R, Loeffler J, Aepinus C, Bock T, Jahn G, Hebart H. Bissinger AL, et al. Diagn Microbiol Infect Dis. 2005 Aug;52(4):275-80. doi: 10.1016/j.diagmicrobio.2005.03.005. Diagn Microbiol Infect Dis. 2005. PMID: 15936168
Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.
Loeffler J, Steffens M, Arlt EM, Toliat MR, Mezger M, Suk A, Wienker TF, Hebart H, Nürnberg P, Boeckh M, Ljungman P, Trenschel R, Einsele H. Loeffler J, et al. J Clin Microbiol. 2006 May;44(5):1847-50. doi: 10.1128/JCM.44.5.1847-1850.2006. J Clin Microbiol. 2006. PMID: 16672419 Free PMC article.
Development and evaluation of the nuclisens basic kit NASBA for the detection of RNA from Candida species frequently resistant to antifungal drugs.
Loeffler J, Dorn C, Hebart H, Cox P, Magga S, Einsele H. Loeffler J, et al. Diagn Microbiol Infect Dis. 2003 Mar;45(3):217-20. doi: 10.1016/s0732-8893(02)00510-2. Diagn Microbiol Infect Dis. 2003. PMID: 12663165
Cellular immunity to viral and fungal antigens after stem cell transplantation.
Einsele H, Hebart H. Einsele H, et al. Curr Opin Hematol. 2002 Nov;9(6):485-9. doi: 10.1097/00062752-200211000-00003. Curr Opin Hematol. 2002. PMID: 12394169 Review.
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