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Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.
Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK. Eizirik DL, et al. Ann N Y Acad Sci. 2003 Nov;1005:55-74. doi: 10.1196/annals.1288.007. Ann N Y Acad Sci. 2003. PMID: 14679040
Long term in vitro effects of streptozotocin, interleukin-1, and high glucose concentration on the activity of mitochondrial dehydrogenases and the secretion of insulin in pancreatic islets.
Rasschaert J, Eizirik DL, Malaisse WJ. Rasschaert J, et al. Among authors: eizirik dl. Endocrinology. 1992 Jun;130(6):3522-8. doi: 10.1210/endo.130.6.1534541. Endocrinology. 1992. PMID: 1534541
Role of receptor binding and gene transcription for both the stimulatory and inhibitory effects of interleukin-1 in pancreatic beta-cells.
Eizirik DL, Tracey DE, Bendtzen K, Sandler S. Eizirik DL, et al. Autoimmunity. 1992;12(2):127-33. doi: 10.3109/08916939209150319. Autoimmunity. 1992. PMID: 1535517
Short exposure of rat pancreatic islets to interleukin-1 beta induces a sustained but reversible impairment in beta-cell function: influence of protease activation, gene transcription, and protein synthesis.
Eizirik DL, Bendtzen K, Sandler S. Eizirik DL, et al. Endocrinology. 1991 Mar;128(3):1611-6. doi: 10.1210/endo-128-3-1611. Endocrinology. 1991. PMID: 1999175
SAM prevents impairment of glucose-stimulated insulin secretion caused by hexose deprivation or starvation.
Conget I, Zhang TM, Eizirik DL, Malaisse WJ. Conget I, et al. Among authors: eizirik dl. Am J Physiol. 1995 Apr;268(4 Pt 1):E580-7. doi: 10.1152/ajpendo.1995.268.4.E580. Am J Physiol. 1995. PMID: 7733255
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.
Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerström C, Andersson A. Eizirik DL, et al. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9253-6. doi: 10.1073/pnas.91.20.9253. Proc Natl Acad Sci U S A. 1994. PMID: 7937750 Free PMC article.
The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells.
Eizirik DL, Flodström M, Karlsen AE, Welsh N. Eizirik DL, et al. Diabetologia. 1996 Aug;39(8):875-90. doi: 10.1007/BF00403906. Diabetologia. 1996. PMID: 8858209 Review.
Mechanisms of defective glucose-induced insulin release in human pancreatic islets transplanted to diabetic nude mice.
Eizirik DL, Jansson L, Flodström M, Hellerström C, Andersson A. Eizirik DL, et al. J Clin Endocrinol Metab. 1997 Aug;82(8):2660-3. doi: 10.1210/jcem.82.8.4150. J Clin Endocrinol Metab. 1997. PMID: 9253350
Intercellular differences in interleukin 1beta-induced suppression of insulin synthesis and stimulation of noninsulin protein synthesis by rat pancreatic beta-cells.
Ling Z, Chen MC, Smismans A, Pavlovic D, Schuit F, Eizirik DL, Pipeleers DG. Ling Z, et al. Among authors: eizirik dl. Endocrinology. 1998 Apr;139(4):1540-5. doi: 10.1210/endo.139.4.5894. Endocrinology. 1998. PMID: 9528932
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells.
Darville MI, Eizirik DL. Darville MI, et al. Among authors: eizirik dl. Diabetologia. 1998 Sep;41(9):1101-8. doi: 10.1007/s001250051036. Diabetologia. 1998. PMID: 9754830
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