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TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.

Cetkovic-Cvrlje M, Eizirik DL. Cetkovic-Cvrlje M, et al. Among authors: eizirik dl. Cytokine. 1994 Jul;6(4):399-406. doi: 10.1016/1043-4666(94)90064-7. Cytokine. 1994. PMID: 7948748

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Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference.

Lopes M, Kutlu B, Miani M, Bang-Berthelsen CH, Størling J, Pociot F, Goodman N, Hood L, Welsh N, Bontempi G, Eizirik DL. Lopes M, et al. Among authors: eizirik dl. Genomics. 2014 Apr;103(4):264-75. doi: 10.1016/j.ygeno.2013.12.007. Epub 2014 Jan 24. Genomics. 2014. PMID: 24462878

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Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival.

Juan-Mateu J, Rech TH, Villate O, Lizarraga-Mollinedo E, Wendt A, Turatsinze JV, Brondani LA, Nardelli TR, Nogueira TC, Esguerra JLS, Alvelos MI, Marchetti P, Eliasson L, Eizirik DL. Juan-Mateu J, et al. Among authors: eizirik dl. J Biol Chem. 2017 Feb 24;292(8):3466-3480. doi: 10.1074/jbc.M116.748335. Epub 2017 Jan 11. J Biol Chem. 2017. PMID: 28077579 Free PMC article.

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Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells.

Brozzi F, Gerlo S, Grieco FA, Juusola M, Balhuizen A, Lievens S, Gysemans C, Bugliani M, Mathieu C, Marchetti P, Tavernier J, Eizirik DL. Brozzi F, et al. Among authors: eizirik dl. J Biol Chem. 2016 Jun 3;291(23):12040-56. doi: 10.1074/jbc.M115.704619. Epub 2016 Apr 4. J Biol Chem. 2016. PMID: 27044747 Free PMC article.

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UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced β Cells Apoptosis.

Brondani LA, Rech TH, Boelter G, Bauer AC, Leitão CB, Eizirik DL, Crispim D. Brondani LA, et al. Among authors: eizirik dl. Transplantation. 2017 Mar;101(3):e59-e67. doi: 10.1097/TP.0000000000001292. Transplantation. 2017. PMID: 28222054

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An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.

Darville MI, Terryn S, Eizirik DL. Darville MI, et al. Among authors: eizirik dl. Endocrinology. 2004 Mar;145(3):1130-6. doi: 10.1210/en.2003-1200. Epub 2003 Nov 20. Endocrinology. 2004. PMID: 14630716

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Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.

Liu D, Cardozo AK, Darville MI, Eizirik DL. Liu D, et al. Among authors: eizirik dl. Endocrinology. 2002 Apr;143(4):1225-34. doi: 10.1210/endo.143.4.8737. Endocrinology. 2002. PMID: 11897677

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IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.

Grieco FA, Moore F, Vigneron F, Santin I, Villate O, Marselli L, Rondas D, Korf H, Overbergh L, Dotta F, Marchetti P, Mathieu C, Eizirik DL. Grieco FA, et al. Among authors: eizirik dl. Diabetologia. 2014 Mar;57(3):502-11. doi: 10.1007/s00125-013-3135-2. Epub 2013 Dec 19. Diabetologia. 2014. PMID: 24352375

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Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL. Welsh N, et al. Among authors: eizirik dl. Diabetes. 2005 Nov;54(11):3238-44. doi: 10.2337/diabetes.54.11.3238. Diabetes. 2005. PMID: 16249450

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PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL. Colli ML, et al. Among authors: eizirik dl. EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27. EBioMedicine. 2018. PMID: 30269996 Free PMC article.

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