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The hERG potassium channel and hERG screening for drug-induced torsades de pointes.
Hancox JC, McPate MJ, El Harchi A, Zhang YH. Hancox JC, et al. Among authors: el harchi a. Pharmacol Ther. 2008 Aug;119(2):118-32. doi: 10.1016/j.pharmthera.2008.05.009. Epub 2008 Jun 18. Pharmacol Ther. 2008. PMID: 18616963 Review.
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.
El Harchi A, McPate MJ, Zhang Yh, Zhang H, Hancox JC. El Harchi A, et al. J Mol Cell Cardiol. 2009 Nov;47(5):743-7. doi: 10.1016/j.yjmcc.2009.02.027. Epub 2009 Mar 10. J Mol Cell Cardiol. 2009. PMID: 19285083 Free PMC article.
Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation.
El Harchi A, McPate MJ, Zhang YH, Zhang H, Hancox JC. El Harchi A, et al. J Physiol Pharmacol. 2010 Apr;61(2):123-31. J Physiol Pharmacol. 2010. PMID: 20436212
Acidosis impairs the protective role of hERG K(+) channels against premature stimulation.
Du CY, Adeniran I, Cheng H, Zhang YH, El Harchi A, McPate MJ, Zhang H, Orchard CH, Hancox JC. Du CY, et al. Among authors: el harchi a. J Cardiovasc Electrophysiol. 2010 Oct;21(10):1160-9. doi: 10.1111/j.1540-8167.2010.01772.x. J Cardiovasc Electrophysiol. 2010. PMID: 20455975
Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform.
Du CY, El Harchi A, McPate MJ, Orchard CH, Hancox JC. Du CY, et al. Among authors: el harchi a. Biochem Biophys Res Commun. 2011 Feb 11;405(2):222-7. doi: 10.1016/j.bbrc.2011.01.014. Epub 2011 Jan 8. Biochem Biophys Res Commun. 2011. PMID: 21219869
The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials.
El Harchi A, Zhang H, Hancox JC. El Harchi A, et al. J Physiol Pharmacol. 2010 Dec;61(6):759-64. J Physiol Pharmacol. 2010. PMID: 21224508
Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis.
DU CY, El Harchi A, Zhang YH, Orchard CH, Hancox JC. DU CY, et al. Among authors: el harchi a. J Cardiovasc Electrophysiol. 2011 Oct;22(10):1163-70. doi: 10.1111/j.1540-8167.2011.02060.x. Epub 2011 Apr 13. J Cardiovasc Electrophysiol. 2011. PMID: 21489024
Molecular determinants of hERG potassium channel inhibition by disopyramide.
El Harchi A, Zhang YH, Hussein L, Dempsey CE, Hancox JC. El Harchi A, et al. J Mol Cell Cardiol. 2012 Jan;52(1):185-95. doi: 10.1016/j.yjmcc.2011.09.021. Epub 2011 Sep 29. J Mol Cell Cardiol. 2012. PMID: 21989164
Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.
El Harchi A, Melgari D, Zhang YH, Zhang H, Hancox JC. El Harchi A, et al. PLoS One. 2012;7(12):e52451. doi: 10.1371/journal.pone.0052451. Epub 2012 Dec 26. PLoS One. 2012. PMID: 23300672 Free PMC article.
Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition.
Du C, El Harchi A, Zhang H, Hancox JC. Du C, et al. Among authors: el harchi a. Physiol Rep. 2013 Nov;1(6):e00175. doi: 10.1002/phy2.175. Epub 2013 Nov 29. Physiol Rep. 2013. PMID: 24400172 Free PMC article.
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